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Obstructive nephroma animal model and its manufacturing method

A technology of obstructive nephropathy and animal models, applied in the medical field, can solve problems such as ureteral injury, difficult to reach the degree of obstruction, long rubber tube, etc., and achieve good tissue compatibility, good repeatability, and simple operation

Inactive Publication Date: 2004-01-28
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

Due to the poor plasticity of the rubber tube, the degree of constriction cannot be well adjusted according to the diameter of the ureter, and it is difficult to achieve the standardization of the degree of obstruction in actual operation, so the repeatability is poor
In addition, the tissue compatibility of the rubber tube is poor, and it is easy to cause rejection and wound healing if left in the body.
Although this method is reversible, due to the long rubber tube and obvious local inflammation and adhesion, it is easy to cause ureteral damage when taken out

Method used

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  • Obstructive nephroma animal model and its manufacturing method
  • Obstructive nephroma animal model and its manufacturing method
  • Obstructive nephroma animal model and its manufacturing method

Examples

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Embodiment

[0022] This example uses wire silver clips. 20 New Zealand white rabbits were randomly divided into two groups, namely the model group and the control group (sham operation group), with 10 rabbits in each group. In the model group, silver clips were installed on bilateral ureters, and in the sham operation group, only ureters were separated without silver clips. Routine feeding for 4 weeks after operation. (1) Observation. Model group: body weight was significantly lower than that of the control group (P<0.05), the volume of the kidney was significantly larger than that of the control group, and the renal pelvis was enlarged.

[0023] Zhang hydrops, renal parenchyma thinning, ureter dilatation above the obstruction. Control group: the body weight increased in different degrees compared with before the experiment, and the renal pelvis and ureter had no dilated effusion. (2) Laboratory examination: model group: blood urea nitrogen (mean 18.93mmol / L), blood creatinine (me...

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Abstract

In the method, the corrosion resisting metal clamp is set on ureters at two sides of animal living body model. The said clamp made from metal wire or sheet material in U type structure composed of two handles and one circular arc, which clamps on ureters. The invention possesses the advantages of favorable histocompatibility, rest interior of the body for a long time without reject reaction, simple modeling procedure and good repeatability.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a method for producing an animal model of obstructive nephropathy. Background technique [0002] In order to study obstructive nephropathy, it is necessary to create a model in a living animal, generally using a live animal model, the existing method of making an animal model of obstructive nephropathy and its existing problems are as follows: [0003] Psoas major tube embedding ureter method: The ureteral obstruction caused by psoas major tube embedding method mainly depends on the tension of the psoas major muscle, and is easily affected by many factors such as the animal's position, activity level, and whether the animal is awake or not. The model has poor controllability and repeatability, and it is difficult to standardize the degree of obstruction. [0004] Ureteral β-ray irradiation method and ureteral Cellophane wrapping method: aim to induce granulation hyperplasia in the lumen ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G09B23/36
Inventor 陈志强
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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