Cervical spondylotic myelopathy experimental animal model and making method thereof

Abstract

The invention relates to a cervical spondylotic myelopathy (CSM) experimental animal model and a making method thereof, belonging to the technical field of osteopathic medicine experimental animal models. According to the technical scheme of the invention, a living rabbit, goat, dog, miniature pig or experimental mouse is used as a model body, a compression nail is placed at C3 cervical vertebra body of the rabbit, goat, dog, miniature pig or experimental mouse, and developing biomaterial is filled inside the filling hole of the compression nail. The making method of the CSM experimental animal model comprises the following steps of: making a hole at the C3 cervical vertebra body, and placing the compression nail into the hole to cause spinal cord ventral compression. The CSM experimental animal model provided by the invention has the following benefits that the C3 cervical vertebra is selected as the vertebral body where the compression nail is placed, which completely breaks the domestic and abroad traditional mode of compression at C4 or C5 cervical vertebra, is a new breakthrough in CSM experimental animal model making and achieves an ideal experimental effect; and the surgical operation is simple and safe, and the change of CSM after long-term chronic compression can be studied in various imaging techniques at the same time.

Description

technical field [0001] The invention relates to an operation compression nail for an experimental animal model of cervical spondylosis and a method for applying the compression nail to making an experimental animal model of cervical spondylosis of the spinal cord, belonging to the technical field of orthopedics and medical experimental animals. Background technique [0002] Cervical spondylotic myelopathy (Cervical spondylotic myelopathy CSM) is mainly caused by cervical disc herniation, cervical vertebral osteophyte formation, ossification of posterior longitudinal ligament, hypertrophy of ligamentum flavum, cervical spinal canal stenosis and cervical spine instability. A syndrome caused by oppression and stimulation. The clinical research on cervical spondylotic myelopathy by scholars at home and abroad has been quite mature and perfect, and their understanding of it has gradually deepened. Basic research on cervical spondylosis is still lacking. The main reason is that ...

AI Technical Summary

Problems solved by technology

Most of the tumors used as spinal cord compressors use metastatic tumors, so the size of the compressor will change with the size of the nodule, and the tumor itself will cause tissue destruction, which has certain implications for the study of intraspinal epidural tumors. value, but there are obvious defects in the study of cervical spondylotic myelopathy: first, the compression of tumors is essentially different from that of cervical degeneration; will cause damage; third, the growth of tumor tissue is uncontrollable

[0010] Through the anatomy of the rabbit's cervical spine and CT and MRI scans, it is found that the shape of the rabbit's cervical vertebral canal and spinal cord is extremely irregular, and the cervical vertebral canal from C2 to C3 is relatively narrow and has a regular oval shape, which is similar to the shape of the human spinal canal. From C4 cervical vertebra to C7 cervical vertebra, the spinal canal gradually becomes flat and wide, which is not consistent with the clinical condition of congenital cervical spinal canal stenosis

At present, the cervical spondylotic myelopathy models made by rabbits (or other animals) all select the compression position of the oppressor (nail or balloon) at the C4 cervical vertebra and the C5 cervical vertebral canal of the rabbit cervical vertebra, so the oppressor (nail or balloon) The compression effect produced by the balloon) cannot accurately reflect the clinical conditions of patients, and the experimental results are not accurate enough for pathological research. This is very unfavorable for the establishment of this animal model, and it is very necessary to solve it.

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