84 results about "Experimental Animal Models" patented technology

The invention relates to a method for calculating tolerance dosage of sugar alcohol and function sugar of the human body. Xylitol is taken as an example, and the method comprises the following steps that mice with the volume of 200 g are selected as experimental animal objects, the mice with the volume of 200 g are divided into six experimental groups and one control group, and there are ten numbered mice of each group; the mice of six experimental mice are fed with the xylitol of different dosages in a filling mode every day; the mice of the control group are fed with saccharose in the filling mode; sufficient drinking water and ordinary feed are provided for the experimental mice; the mice are checked every night, and the diarrheal mice are counted; the feeding mode lasts for 14 days; the maximum tolerated dosage of the xylitol of the mice of each group is obtained according to diarrhea conditions of the mice on the last day, intestinal segment slice images of all the mice and the result of content of diamine oxidase; according to a drug dosage reduction formula between the experimental animal and the human, the maximum tolerated dosage of the mouse is converted to obtain the tolerance dosage of the xylitol of the human body. In an animal experiment mode, the range of the tolerance dosage of the sugar alcohol and the function sugar of the human body is obtained more accurately.