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System for efficiently sampling automatic release rate

An automatic release and sampling system technology, applied in the direction of material inspection products, testing pharmaceutical preparations, etc., can solve the problems of inaccurate experimental data, experimental time error, etc., to avoid inaccurate experimental data, excellent sealing effect, strong dissolution force Effect

Pending Publication Date: 2019-02-01
LUGEN INSTR ZHENJIANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Therefore, when performing a dissolution test, it is often necessary to fully simulate various parts of the stomach and intestinal tract. This process requires the use of multiple or even multiple solvent outer tubes to simulate the environment. The current dissolution apparatus, in one experiment, Most of them use the same solvent outer tube. When changing the environment of the drug, it is necessary to take out the drug basket and replace the solvent outer tube. In this way, there will be errors in the experimental time, which will easily lead to inaccurate experimental data.

Method used

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  • System for efficiently sampling automatic release rate
  • System for efficiently sampling automatic release rate
  • System for efficiently sampling automatic release rate

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Embodiment Construction

[0079] In order to make the technical solution of the present invention clearer, the present invention will be further described below in conjunction with the accompanying drawings. Any solution obtained by equivalent replacement and conventional reasoning of the technical features of the technical solution of the present invention falls within the protection scope of the present invention. The fixed connection, fixed arrangement, and fixed structure mentioned in this embodiment are all known techniques known to those skilled in the art, such as welding, screw connection, bolt-nut connection, and riveting. In this embodiment, the controller is a PLC controller, and the PLC controller controls the movement of the vertical movement mechanism and the horizontal movement mechanism through software programming. In this embodiment, the controller is a PLC controller, and the PLC controller controls the movement of the vertical movement mechanism and the horizontal movement mechanism ...

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Abstract

Disclosed is a system for efficiently sampling automatic release rates. The system is characterized by comprising a base, a water tank, a vertical moving mechanism, a horizontal moving mechanism, a controller, a display, a sampling support, an inner pipe mounting frame, an inner pipe, a solvent outer pipe, and a solvent outer pipe placing plate. According to the system for efficiently sampling theautomatic release rates disclosed by the invention, intestinal peristalsis is simulated by means of up-down movement, means that the inner pipe moves up and down in the solvent outer pipe is adopted,the solvent outer pipe is used to simulate the gastrointestinal environment inside the human body, and the inner pipe moves up and down inside the solvent outer pipe, so that the dissolution force ishigh; and on the other hand, the system is more suitable for gastrointestinal motility, using the up and down movement to simulate the gastrointestinal motility environment is more appropriate, and the experimental results are good.

Description

technical field [0001] The invention belongs to the technical field of testing and testing equipment for drug research and development and quality control, in particular to a high-efficiency automatic release rate sampling system. Background technique [0002] In order to produce a desired pharmacological effect, the drug must be made available in the body at an appropriate concentration at its site of action. This effectiveness is influenced by a variety of factors including: the amount of drug administered, the rate of drug absorption, distribution (binding or localization) in tissues, drug metabolism, and elimination from the body. [0003] As an inspection method for drug properties, dissolution testing plays an important role in the quality consistency evaluation of generic drug preparations and changes after approval. The United States Pharmacopoeia divides drug dissolution release devices into 1-7 methods, of which the third method is the reciprocating cylinder metho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/15
CPCG01N33/15
Inventor 李定中宋水军姚鹏志
Owner LUGEN INSTR ZHENJIANG
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