3results about How to "Stable retention time" patented technology

The invention establishes a rapid, accurate and efficient high performance liquid chromatography-mass spectrometry detection method for detecting the common antipsychotic drugs in the hair, and the concentration of ten common antipsychotic drugs or metabolites in the hair can be quantitatively detected at the same time; the method is suitable for clinical blood concentration monitoring, drug poisoning screening and large-scale biological sample detection, and has very significant significance in clinical use.

The application provides a construction method of a characteristic map of Adiantum capillus-veneris and a content determination method of characteristic components of the Adiantum capillus-veneris. The construction method of the characteristic map comprises the following steps: taking chlorogenic acid, 3-O-p-coumaroyl quinic acid and kaempferol-3-O-beta-D-glucuronide as reference substances to obtain reference substance solutions; mixing the Adiantum capillus-veneris with an extraction solvent and performing heating reflux treatment or ultrasonic treatment, and then filtering the Adiantum capillus-veneris after cooling to obtain a test sample solution; placing the test sample solution and the plurality of reference substance solutions in a high performance liquid chromatograph, determining high performance liquid chromatograms of the test sample solution and the reference substance solutions, taking the high performance liquid chromatograms of the reference substance solutions as a control, selecting common peaks from the high performance liquid chromatogram of the test sample solution, and obtaining a characteristic map of the Adiantum capillus-veneris. The above method has excellent precision, repeatability, stability and durability, and is significantly superior to traditional single component determination or non-standardized methods.

The application discloses a method for detecting the concentration of formic acid in high-concentration sulfuric acid by high performance liquid chromatography, and belongs to the technical field of concentration detection. The method comprises the following steps: establishing a formic acid standard curve, filtering a sample through an acid-resistant filter membrane, directly injecting the sample, and detecting and calculating the formic acid content by using high performance liquid chromatography. The method is suitable for a 4-8 M sulfuric acid system, and can realize effective separation and accurate quantification of formic acid in a high-sulfate background. The method is simple in operation, and is suitable for rapid detection of formic acid in an industrial process and a complex reaction system.