Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Gas chromatography method for simultaneously detecting n-heptane, isooctane, ethyl acetate and isopropanol and use thereof

A gas chromatographic analysis and ethyl acetate technology, which is applied in the fields of pharmaceutical synthesis and chemical industry, can solve the problems of not being environmentally friendly, time-consuming and labor-intensive, and waste of detection reagents, and achieve the effects of stable retention time, good separation effect and high accuracy.

Inactive Publication Date: 2016-07-27
JIANGSU WANBANG BIOPHARMLS +1
View PDF6 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

National standards have clear residue requirements for this, but the detection methods in the current national standards are all single detection methods for specific components, for example, they only detect n-heptane, so that in order to combine these four common The determination of the residual amount of all residual components requires four test operations, which is not only time-consuming and labor-intensive, but also wastes a lot of detection reagents, which does not meet the requirements of the modern era such as environmental friendliness

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Gas chromatography method for simultaneously detecting n-heptane, isooctane, ethyl acetate and isopropanol and use thereof
  • Gas chromatography method for simultaneously detecting n-heptane, isooctane, ethyl acetate and isopropanol and use thereof
  • Gas chromatography method for simultaneously detecting n-heptane, isooctane, ethyl acetate and isopropanol and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Accurately weigh 0.1 g of the drug to be tested, put it in a headspace bottle, add 1 ml of dimethyl sulfoxide to dissolve it, seal it, and use it as the test solution.

[0029] In addition, accurately weigh the appropriate amount of isopropanol, ethyl acetate, isooctane and n-heptane, and add dimethyl sulfoxide to dilute to make a mixed solution containing 500 μg of isopropanol, 500 μg of ethyl acetate, and 500 μg of isooctane. , 500 μg of n-heptane reference substance solution.

Embodiment 2

[0031] The test solution and the reference solution were measured according to the residual solvent determination method (the second method of appendix VIIIP in the second part of the Chinese Pharmacopoeia 2010 edition), and the chromatograms of the reference solution were respectively obtained. figure 1 And the chromatogram of the test solution figure 2 . The test results are compared in the table below.

[0032]

Embodiment 3

[0034] Take 1mL of the test solution, put it in a 20ml headspace bottle, heat it at 80°C for 30 minutes, and then use the gas chromatography analysis method disclosed in the present invention to detect: the reagent sample is directly injected into the gas phase by manual injection. In the chromatograph, the injection volume is 1 μL. Using the DB-624 chromatographic column, set the initial temperature of the column temperature to 40°C, maintain it for 8 minutes, then raise the temperature to 220°C at a speed of 15°C per minute, and maintain it for 6 minutes; the temperature of the injection port is 250°C; the detector (FID ) temperature is 280°C; the carrier gas is nitrogen; record the chromatogram and get Figure 2 to Figure 6 .

[0035] Get 1mL of the reference substance solution, place it in a 20ml headspace bottle, heat it at 80°C for 30 minutes, and then use the gas chromatography analysis method disclosed in the present invention to detect: the test solution is directly ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
volumeaaaaaaaaaa
Login to View More

Abstract

The invention relates to a gas chromatography method for simultaneously detecting n-heptane, isooctane, ethyl acetate and isopropanol and a use thereof. The gas chromatography method can be operated simply, has good peak shapes, high column efficiency, good separation effects, good stability and good reappearance and is suitable for four reagents. The invention discloses the gas chromatography method. The method comprises directly injecting n-heptane, isooctane, ethyl acetate and isopropanol into a gas chromatograph, treating the samples carried by nitrogen through a capillary column chromatographic column with 6% cyanopropylphenyl-94% dimethyl polysiloxane as a fixing solution and carrying out gas chromatography-based qualitative and quantitative analysis on the detected data. The gas chromatography method realizes convenient and fast purity detection of n-heptane, isooctane, ethyl acetate and isopropanol. All the reagents have stable main peak retention time, good peak shapes and good separation effects and satisfy requirements on medicine synthesis or chemical synthesis residual reagent detection and quality control.

Description

technical field [0001] The invention relates to the fields of medicine synthesis and chemical industry, in particular to a gas chromatography analysis method for simultaneously detecting n-heptane, isooctane, ethyl acetate and isopropanol. Background technique [0002] N-heptane, isooctane, ethyl acetate, and isopropanol are common organic residual solvents in pharmaceutical and chemical synthesis. National standards have clear residue requirements for this, but the detection methods in the current national standards are all single detection methods for specific components, for example, they only detect n-heptane, so that in order to combine these four common The determination of the residual amount of all residual components requires four test operations, which is not only time-consuming and labor-intensive, but also wastes a lot of detection reagents, which does not meet the requirements of the modern era such as environmental friendliness. Contents of the invention ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 王飞林彬刘跃跃乔德水高雪芹
Owner JIANGSU WANBANG BIOPHARMLS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com