A kind of multi-substituted 3-phenylphenol derivatives and its preparation method
A phenylphenol and polysubstituted technology, applied in the field of polysubstituted 3-phenylphenol derivatives and their preparation, can solve the problems of harsh synthesis conditions, complicated steps, etc., and achieves short reaction time, complex and diverse structures, and wide applications. Foreground effect
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[0035] A kind of multi-substituted 3-phenylphenol derivatives, its structural formula is:
[0036]
[0037] A kind of preparation method of substituted 3-phenylphenol derivatives, described preparation method comprises the following steps:
[0038] (1) With 830mmol sodium hydride as a catalyst, 200mmol dimethyl malonate and 440mmol propargyl bromide were added to 210mL anhydrous acetonitrile in an ice-water bath, stirred and reacted for 8 hours, the product was washed with water, extracted with ethyl acetate, and Press and spin dry to obtain a brownish-yellow solid product, namely compound 1;
[0039] (2) Mix 80mmol compound 1 with 200mmol phenylethynyl bromide in Pd(PPh 3 ) 2 Cl 2 / CuI(2.56mmol / 0.85mmol) anhydrous and oxygen-free catalytic system, the molar ratio of Pd(PPh 3 ) 2 Cl 2 : CuI=3:1, with 336mmol triethylamine as base, 150mL anhydrous acetonitrile as solvent, stirring and reacting at room temperature for 12 hours, the product was washed with water, extract...
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