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Application of cortex moutan extract in preparation of hypoglycaemic agent

A technology of extract and paeonol, applied in the field of medicine, achieves the effects of simple preparation method, abundant raw materials, and development of new uses

Inactive Publication Date: 2014-12-10
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the development of science and technology and the further development of traditional Chinese medicine, the application value of paeonol is more and more valued by people. Therefore, the research on paeonol is widespread, but so far no paeonol extract has been used in the preparation of hypoglycemic drugs Public reporting of applications in

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  • Application of cortex moutan extract in preparation of hypoglycaemic agent
  • Application of cortex moutan extract in preparation of hypoglycaemic agent
  • Application of cortex moutan extract in preparation of hypoglycaemic agent

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Embodiment Construction

[0006] The specific implementation of the present invention will be described in detail below in combination with specific situations.

[0007] In the specific implementation of the present invention, a kind of paeonol extract is used in the preparation of hypoglycemic drugs. The paeonol extract is obtained by taking the paeonol medicinal material, pulverizing it into a coarse powder passing through a 20-mesh sieve, adding 15 times the weight of The NaCl aqueous solution with a mass concentration of 5% is soaked at room temperature for 2 hours, then extracted by steam distillation for 5 hours, the flow rate of the distillate is controlled at 9ml / min per 300g of medicinal materials, the distillate is collected, and after cooling to room temperature, the distillate is refrigerated at 4°C for 24 hours , when the paeonol crystals are separated out, filter to obtain the first crystal; the filtrate is added with 15 times the weight of NaCl with a mass concentration of 5%, redistilled...

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Abstract

The invention relates to application of cortex moutan extract in preparation of a hypoglycaemic agent and aims at solving the problem of preparation of the hypoglycaemic agent. According to the technical scheme, the cortex moutan extract is obtained by the following steps: taking a cortex moutan medicinal material, smashing cortex moutan into coarse powder, adding NaCl aqueous solution, soaking, then distilling and extracting, collecting distillate, cooling to room temperature, refrigerating, after cortex moutan phenol crystals are separated out, filtering to obtain primary crystals; adding NaCl into filtrate, distilling again, collecting distillate with the volume of being three times that of the filtrate, refrigerating, staying overnight, filtering to obtain secondary crystals, putting the primary crystals and the secondary crystals together, and drying under reduced pressure, so that the cortex moutan extract is obtained, wherein cortex moutan phenol mass content is more than 80%. Raw materials are available, a preparation method is simple, the obtained cortex moutan extract is effective and can be used for preparing the hypoglycaemic agent, so that the application of the cortex moutan extract in the preparation of the hypoglycaemic agent is realized; meanwhile, the cortex moutan extract also can be used for further realizing preparation of a drug used for treating diabetes, so that medicinal value of cortex moutan is increased and a new application of the cortex moutan is developed.

Description

technical field [0001] The invention relates to medicine, in particular to the application of a paeonol extract in the preparation of hypoglycemic drugs. Background technique [0002] Cortex paeonol is the dry root bark of peony of Ranunculaceae. Produced in Anhui, Sichuan, Henan, Shandong and other places. It has the effects of clearing heat and cooling blood, promoting blood circulation and removing stasis, and reducing asthenia heat. With the development of science and technology and the further development of traditional Chinese medicine, the application value of paeonol is more and more valued by people. Therefore, the research on paeonol is widespread, but so far no paeonol extract has been used in the preparation of hypoglycemic drugs Public reports of applications in . Contents of the invention [0003] In view of the above situation, in order to overcome the defects of the prior art, the object of the present invention is to provide an application of paeonol ex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P3/10
Inventor 苗明三王灿苗艳艳
Owner HENAN UNIV OF CHINESE MEDICINE
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