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Method for extracting acacetin from chrysanthemum

A technology of acacia locust and chrysanthemum, which is applied in directions such as organic chemistry, can solve problems such as no reports on the preparation process of high-purity locust locust, and achieve the effects of low production cost, less solvent consumption and simple operation.

Active Publication Date: 2012-06-13
HUBEI NUOKETE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the preparation process suitable for the industrialized large-scale production of high-purity locust

Method used

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  • Method for extracting acacetin from chrysanthemum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 Get 10 kg of chrysanthemums, pulverize them, add 80% ethanol with a concentration of 15 times its mass and volume, put it into a microwave extraction device and carry out microwave extraction, extraction power 300W, extraction 2 times, each 5 minutes, combined extracts, Filter, reclaim ethanol under reduced pressure and concentrate, add to D101 type macroporous adsorption resin column for adsorption, elute with 50% ethanol, collect 3 times of column volume eluate, reclaim ethanol under reduced pressure and concentrate, add to polyamide ( On the polyamide 6) chromatographic column, elute with a dichloromethane-methanol mixed solvent with a ratio of 4:1, use the same type of polyamide film to develop with the above-mentioned eluent as a supporting detection, and collect the corresponding polyamide film. For fractions with Rf=4-5, the solvent was recovered under reduced pressure, acetone was added to crystallize, the crystals were separated, washed and dried to...

Embodiment 2

[0021] Embodiment 2 Get 10 kg of chrysanthemums, pulverize them, add 85% ethanol with a concentration of 18 times its mass and volume, put it into a microwave extraction device and carry out microwave extraction, extraction power 400W, extraction 3 times, 10 minutes each time, combine the extracts, Filter, reclaim ethanol under reduced pressure and concentrate, add to D102 type macroporous adsorption resin column for adsorption, elute with 60% ethanol, collect 5 times of column volume eluate, reclaim ethanol under reduced pressure and concentrate, add to polyamide ( Polyamide 66) chromatographic column, eluted with a mixed solvent of dichloromethane-methanol in a ratio of 4:1, and the same type of polyamide film was developed with the above-mentioned eluent as a supporting detection, and the corresponding polyamide film was collected. For fractions with Rf=4-5, the solvent was recovered under reduced pressure, acetone was added to crystallize, the crystals were separated, washe...

Embodiment 3

[0022] Example 3 Take 10 kg of chrysanthemums, pulverize them, add 90% ethanol with a concentration of 20 times its mass and volume, put it into a microwave extraction device and carry out microwave extraction, with an extraction power of 600W, extract 4 times, each time for 20 minutes, combine the extracts, Filtrate, recover ethanol under reduced pressure and concentrate, add to AB-8 macroporous adsorption resin column for adsorption, elute with 70% ethanol, collect 8 times the column volume eluate, recover ethanol under reduced pressure and concentrate, add to poly On the amide (polyamide 11) chromatographic column, it was eluted with a mixed solvent of dichloromethane-methanol at a ratio of 4:1, and the same type of polyamide film was developed with the above-mentioned eluent as a supporting detection, and the corresponding polyamide was collected. For fractions with Rf=4-5 on the film, the solvent was recovered under reduced pressure, acetone was added to crystallize, the c...

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Abstract

The invention relates to a method for extracting acacetin from chrysanthemum, which includes: using microwave extraction to obtain extract, adding the extract on a macroporous adsorption resin column to be absorbed, eluting, decompressing, recovering and concentrating ethanol, adding the ethanol to a polyamide chromatographic column, eluting, using a homogeneous polyamide film which is unfolded by eluent to serve as matching detection, collecting, decompressing and recovering solvent, adding acetone in the solvent to obtain crystallization, separating the crystallization, washing, drying and obtaining the acacetin. The method is simple to operate, small in solvent consumption, low in production cost, stable in process, low in energy consumption, less in pollution, high in purity (99%) of obtained products and capable of being applied to laboratories and industrial semi-preparation and preparation production.

Description

technical field [0001] The invention relates to a method for extracting acaciatin, in particular to a method for extracting acaciacin from chrysanthemums. Background technique [0002] Chrysanthemum is the dry flower head of Chrysanthemum morifolium Ramat, a plant in the Compositae family. It is a commonly used traditional Chinese medicine in my country. It mainly treats symptoms such as headache, dizziness, red eyes, dysphoria in the heart and chest, furunculosis, and swelling. Modern pharmacological studies have shown that chrysanthemum has various pharmacological activities such as treating coronary heart disease, lowering blood pressure, preventing hyperlipidemia, antibacterial, antiviral, anti-inflammatory, and anti-aging. Chrysanthemum contains acacia element, the structural formula is: [0003] [0004] Studies have shown that locustine has a vitamin P-like effect. Oral administration of locustine in mice can reduce formaldehyde-induced inflammation, and can also...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30C07D311/40
Inventor 不公告发明人
Owner HUBEI NUOKETE PHARMA
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