External pharmaceutical composition for treating vasogenic vertigo and application thereof

A technology for vascular vertigo and external use of drugs, which is used in drug combinations, cardiovascular system diseases, medical preparations containing active ingredients, etc.

Active Publication Date: 2022-07-29
SHANDONG ACAD OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The existing treatment for vasogenic vertigo is oral administration of traditional Chinese medicine or western medicine, and few external medicines

Method used

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  • External pharmaceutical composition for treating vasogenic vertigo and application thereof
  • External pharmaceutical composition for treating vasogenic vertigo and application thereof
  • External pharmaceutical composition for treating vasogenic vertigo and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A pharmaceutical composition for treating vascular vertigo, comprising the following components in proportion by weight: 5.8 parts of isorhamnetin; 24.7 parts of kaempferol; 33.6 parts of chuanmene; 3.0 parts of isoflavone; 7.1 parts of acacetin ; Aloe-emodin 31.3 parts; Luteolin 74.1 parts; Baicalein 45.6 parts; Hydroxyflorin 62.9 parts; Hesperetin 39.7 parts.

Embodiment 2

[0045] A pharmaceutical composition for treating vascular vertigo, comprising the following components in proportion by weight: 57.6 parts of isorhamnetin; 24.7 parts of kaempferol; 33.6 parts of chenolide; 29.7 parts of isoflavone; 70.7 parts of acacetin ; Aloe-emodin 31.3 parts; Luteolin 74.1 parts; Baicalein 45.6 parts; Hydroxyflorin 62.9 parts; Hesperetin 39.7 parts.

Embodiment 3

[0047] A pharmaceutical composition for treating vascular vertigo, comprising the following components in proportion by weight: 30 parts of isorhamnetin; 12 parts of kaempferol; 16 parts of tangerine peel; 15 parts of verisin; 35 parts of acacetin ; Aloe-emodin 16 parts; Luteolin 37 parts; Baicalein 22 parts; Hydroxyflorin 32 parts; Hesperetin 20 parts.

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Abstract

The invention belongs to the field of medicine research and development, and particularly relates to an external medicine composition for treating vasogenic vertigo and application. The pharmaceutical composition comprises the following components in parts by weight: 5.8 to 57.6 parts of isorhamnetin; 2.5 to 24.7 parts of kaempferol; 3.4 to 33.6 parts of nobiletin; 3.0 to 29.7 parts of calycosin; 7.1 to 70.7 parts of acacetin; 3.1 to 31.3 parts of aloe emodin; 7.4 to 74.1 parts of luteolin; 4.6 to 45.6 parts of baicalein; 6.3 to 62.9 parts of hydroxy genkwanin; and 4.0 to 39.7 parts of hesperetin. The effective rate of the pharmaceutical composition can reach 92.08%. The artemisia argyl oil is used as a penetration enhancer, so that the transdermal absorption curative effect of the medicine is improved, the liver first-pass effect of the medicine can be avoided, the bioavailability of the medicine is improved, the interference on the medicine absorption is reduced, the treatment effect is enhanced, and the administration can be continuously controlled and interrupted at any time.

Description

technical field [0001] The invention belongs to the field of drug research and development, and in particular relates to a pharmaceutical composition for external use for treating vascular vertigo and its application. Background technique [0002] Vasogenic vertigo refers to a type of vertigo mainly caused by cerebrovascular diseases, accounting for more than 50% of all kinds of vertigo. Vasogenic vertigo is mostly from the posterior circulation, the vertebrobasilar system. The highest frequency of vertigo occurred in the internal auditory artery, AICA, and PICA. Its pathogenesis is due to atherosclerosis, increased blood viscosity, low blood pressure and other reasons, resulting in thrombosis of the internal auditory artery or other arteries or transient ischemic attack, resulting in brainstem ischemia and inner ear ischemia and hypoxia. Vascular wall permeability increases, membrane labyrinth accumulates, resulting in impaired neuronal metabolism, including oxidative dam...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/122A61K9/70A61K47/44A61P1/08A61P9/14
CPCA61K31/352A61K31/122A61K9/7023A61K47/44A61P1/08A61P9/14A61K2300/00Y02A50/30
Inventor 徐男时海燕时银屏王平王建凤
Owner SHANDONG ACAD OF CHINESE MEDICINE
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