Flexible substrate-based micro-needle array for subcutaneous medicament injection and preparation method thereof

A flexible substrate and microneedle array technology, applied in the field of microneedle arrays based on flexible substrates and its manufacturing method, can solve problems such as poor adhesion of rigid substrates, waste of microneedle drugs, and inability to achieve therapeutic effects

Inactive Publication Date: 2010-11-10
INST OF SEMICONDUCTORS - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of microinjector is made of hard materials, and due to the unevenness of the skin, some microneedles cannot be completely inserted into the skin, resulting in waste of medicine (such as figure 1 Shown), can not achieve the expected therapeutic effect
Poor adhesion between rigid substrates and skin, prone to peeling off during testing

Method used

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  • Flexible substrate-based micro-needle array for subcutaneous medicament injection and preparation method thereof
  • Flexible substrate-based micro-needle array for subcutaneous medicament injection and preparation method thereof
  • Flexible substrate-based micro-needle array for subcutaneous medicament injection and preparation method thereof

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0031] see figure 2 and image 3 As shown, the present invention is a microneedle array based on a flexible substrate for subcutaneous drug injection, comprising:

[0032] A base 3. The base 3 is a flexible material with a thickness ranging from several tens of microns to several millimeters. It is a high-toughness material, which can be deformed with the ups and downs of the skin and is not easy to break. The flexible material can closely fit the skin, forming an adsorption force with the skin, and the micro-syringe can be firmly adsorbed on the skin surface. The substrate 3 includes: a flexible surface layer 31 and a flexible back layer 32, the material of the flexible surface layer 31 and the flexible back layer 32 is silica gel, the periphery of the flexible surface layer 31 and the flexible back layer 32 are fixed, and a cavity is formed in the middle Chamber 33, the chamber 33 is used to accommodate the liquid medicine. A plurality of microneedles 1 are embedded on t...

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Abstract

The invention provides a flexible substrate-based micro-needle array for subcutaneous medicament injection. The micro-needle array comprises a substrate made of a flexible material, wherein the substrate comprises a flexible surface layer and a flexible back layer of which the peripheries are fixed; a chamber is formed between the flexible surface layer and the flexible back layer; a plurality of micro-needles are embedded in the flexible surface layer in the substrate; the middle of each micro-needle is provided with a micropore; and the micropores are communicated with the chamber of the substrate so as to form a fluid passage.

Description

technical field [0001] The invention relates to the field of design and microprocessing of medical devices, and more specifically relates to a microneedle array based on a flexible substrate for subcutaneous drug injection and a manufacturing method thereof. Background technique [0002] In medical treatment, patients usually have two methods of ingesting medicines: (1) Oral administration, but some medicines are easily decomposed and destroyed by the action of gastric acid and digestive enzymes in the digestive tract, reducing or losing their efficacy. (2) For intramuscular or intravenous injection, the needle and skin must be prepared and strictly disinfected before intravenous injection. Usually the injection is achieved by inserting a long hollow stainless steel needle into the body to achieve drug injection. This method of drug injection will cause pain to the patient, and improper handling may cause bleeding or even infection, especially for those patients who need lon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M5/00A61M37/00
CPCA61M37/0015A61M2037/003A61M2037/0023
Inventor 裴为华王宇郭凯归强王淑静朱琳陈弘达
Owner INST OF SEMICONDUCTORS - CHINESE ACAD OF SCI
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