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Preparation method of titanium-based conductive hydrogel composite coating material

A conductive hydrogel and composite coating technology, which is applied in the direction of electrolytic organic material coating, coating, polyether coating, etc., can solve the problems of carbon nanotubes and their composite materials that are difficult to disperse and easy to agglomerate, and achieve the goal of increasing the base The surface area and electrical conductivity of the material, the effect of high bonding strength and excellent coating bonding force

Inactive Publication Date: 2016-05-04
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] China invented "a method for preparing a carbon nanotube composite conductive hydrogel coating modified electrode", application number 201310086311.x discloses a method for preparing a carbon nanotube composite conductive hydrogel coating modified electrode by electrophoretic deposition , to overcome the problems of carbon nanotubes and their composite materials that are difficult to disperse, easy to agglomerate, and potential biosafety risks in aqueous solution systems
The use of electrochemical deposition of polymer monomers to prepare conductive hydrogel composite coating materials with high conductivity and uniform texture has not been reported yet.

Method used

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  • Preparation method of titanium-based conductive hydrogel composite coating material
  • Preparation method of titanium-based conductive hydrogel composite coating material
  • Preparation method of titanium-based conductive hydrogel composite coating material

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Experimental program
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Embodiment 1

[0030] After the surface of titanium or titanium alloy is blasted, it is ultrasonically cleaned with ethanol, acetone and deionized water for 10 minutes, and then dried with nitrogen. After gold spraying treatment, ultrasonically clean with ethanol, acetone and deionized water respectively for 10 min, and blow dry with nitrogen gas. The dried titanium or titanium alloy was placed in 0.05mol / L dithiothreitol at 25°C for 5 hours, then dried with nitrogen and soaked in 0.05mol / L n-dodecanethiol at 25°C for 5 minutes, and washed with ethanol After 3 times, blow dry with nitrogen to obtain titanium or its alloy material grafted with mercapto groups on the surface.

Embodiment 2

[0032] After the surface of titanium or titanium alloy is blasted, it is ultrasonically cleaned with ethanol, acetone and deionized water for 10 minutes, and then dried with nitrogen. After gold spraying treatment, ultrasonically clean with ethanol, acetone and deionized water respectively for 10 min, and blow dry with nitrogen gas. The dried titanium or titanium alloy is placed in 60°C, 0.05mol / L dithiothreitol for 1 hour, then dried with nitrogen, soaked in 60°C, 0.05mol / L n-dodecanethiol for 5 minutes, and washed with ethanol After 3 times, blow dry with nitrogen to obtain titanium or its alloy material grafted with mercapto groups on the surface.

Embodiment 3

[0034] After the surface of titanium or titanium alloy is blasted, it is ultrasonically cleaned with ethanol, acetone and deionized water for 10 minutes, and then dried with nitrogen. After gold spraying treatment, ultrasonically clean with ethanol, acetone and deionized water respectively for 10 min, and blow dry with nitrogen gas. The dried titanium or titanium alloy was placed in 0.05mol / L dithiothreitol at 25°C for 5 hours, then dried with nitrogen and soaked in 0.05mol / L n-dodecanethiol at 25°C for 5 minutes, and washed with ethanol After 3 times, blow dry with nitrogen to obtain titanium or its alloy material grafted with mercapto groups on the surface. Prepare titanium or its alloy hydrogel coating by enol click reaction with Gelatinmethacrylate (GelMA) hydrogel under ultraviolet light, ultraviolet light for 30s, and ultraviolet light intensity 690mW / cm 2 , the photoinitiator is Igracure2959. Titanium or its alloy hydrogel coating is frozen and dried for 3D.

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Abstract

The invention relates to a preparation method of a titanium-based conductive hydrogel composite coating material and belongs to the technical field of preparation of medical materials. The method comprises the steps that sand or metal is sprayed on the surface of titanium or titanium alloy, a hydrogel coating is prepared through an enol form click reaction after self-assembly of mercapto groups, and finally electrochemical deposition is conducted on a polymer monomer solution so as to prepare a conductive hydrogel coating on the surface of the titanium or titanium alloy. The electrochemical deposition technology adopted in the invention has the advantages of being mild in reaction condition, controllable and the like; besides, the prepared conductive hydrogel composite coating material has good chemical stability and excellent electrical conductivity, and the binding force of a traditional hydrogel coating and a base material is enhanced; after being excited by in-vitro electrical stimulation, the titanium-based conductive hydrogel composite coating material can be applied to regeneration and repair of myocardial tissue and nervous tissue, osseointegration and the like; and the titanium-based conductive hydrogel composite coating material can be used as a good conductive medical artificial bone tissue material to be applied to clinic treatment.

Description

technical field [0001] The invention relates to a method for preparing a titanium-based conductive hydrogel composite coating material, in particular to a method for preparing a conductive hydrogel composite coating material by self-assembly of mercapto groups on the surface of titanium or its alloy material and enol click reaction , belongs to the technical field of medical material preparation. Background technique [0002] Artificial joint prosthesis or other implants are currently a hot topic in bone and joint repair and replacement research. The materials implanted into the human body not only need good biocompatibility, can quickly fuse with the surrounding tissues of the human body, but also need to have good mechanical properties and other specific physical and chemical properties. Titanium or its alloys are currently the most commonly used support materials for artificial bone due to their low toxicity, low corrosion rate, and excellent osseointegration properties....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D9/02C09D189/00C09D171/08C09D105/08C09D105/04C08L61/12
CPCC08L61/12C09D105/04C09D105/08C09D171/00C09D189/00C25D9/02
Inventor 谭帼馨刘燕周蕾欧阳孔友
Owner GUANGDONG UNIV OF TECH
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