An inorganic fluorescent quantum dot-rhodamine composite bulk temperature-sensitive hydrogel

A technology of temperature-sensitive hydrogel and quantum dots, which is applied in the direction of luminescent materials, chemical instruments and methods, etc., can solve the problems of restricting wide application and single performance of nanomaterials, and achieve rapid response capability, high pressure resistance, and simple synthesis process Effect

Inactive Publication Date: 2011-12-28
CHINA PHARM UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, there are few reports on inorganic fluorescent quantum dot composite bulk temperature-sensitive hydrogels, especially the fluorescence resonance energy transfer system constructed by the composite of inorganic fluorescent quantum dots and organic fluorescent probes has not been involved in the field of hydrogel research.
[0005] Therefore, the nanomaterials doped in the reported composite hydrogels can only improve a single property, and the nanomaterials that endow the hydrogel with two or more superior properties have not been reported, thus limiting its wider application. Applications
At present, there is no block hydrogel that not only responds quickly to temperature, but also has high light transmittance and high pressure resistance, and also has fluorescence characteristics and fluorescence resonance energy transfer system.

Method used

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  • An inorganic fluorescent quantum dot-rhodamine composite bulk temperature-sensitive hydrogel
  • An inorganic fluorescent quantum dot-rhodamine composite bulk temperature-sensitive hydrogel
  • An inorganic fluorescent quantum dot-rhodamine composite bulk temperature-sensitive hydrogel

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Experimental program
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Effect test

Embodiment 1

[0033] Add 100mg monomer N-isopropylacrylamide into the mixed system of 0.5ml CdTe quantum dot aqueous solution and 0.25ml rhodamine B aqueous solution, and dissolve it ultrasonically at room temperature to form a uniform transparent solution; add crosslinking agents N, N 200 μl of '-methylenebisacrylamide, 180 μl of ammonium persulfate as initiator, and 20 μl of N,N,N,N-tetramethylethylenediamine (TEMED) as accelerator, each reagent added was mixed uniformly by magnetic stirring. React at a low temperature of 4°C for 1 hour to obtain a transparent bulk hydrogel. The product has high transparency, and the light transmittance is greater than 90%; it has two characteristic fluorescence peaks at 508nm and 579nm; its swelling ratio is 60.2%; and it can still return to its original state after being subjected to a pressure of 70Mpa.

Embodiment 2

[0035] Add 100mg monomer N-isopropylacrylamide into the mixed system of 0.625ml CdTe quantum dot aqueous solution and 0.125ml Rhodamine B aqueous solution, and dissolve it ultrasonically at room temperature to form a uniform transparent solution; add crosslinking agents N, N' in sequence - 200 μl of methylenebisacrylamide, 180 μl of initiator ammonium persulfate, 10 μl of accelerator N,N,N,N-tetramethylethylenediamine (TEMED), each reagent added was mixed uniformly by magnetic stirring. React at a low temperature of 0°C for 1.5 hours to obtain a transparent bulk hydrogel. The product has high transparency and a light transmittance greater than 90%; it has two characteristic fluorescence peaks at 508nm and 579nm; its swelling ratio is 66.2%; and it can still return to its original state after being subjected to a pressure of 70Mpa.

Embodiment 3

[0037] Add 100mg monomer N-isopropylacrylamide into the mixed system of 0.75ml CdTe quantum dot aqueous solution and 0.125ml rhodamine B aqueous solution, and ultrasonically dissolve at room temperature to form a uniform transparent solution; add crosslinking agents N, N 200 μl of '-methylenebisacrylamide, 180 μl of ammonium persulfate as initiator, and 15 μl of N,N,N,N-tetramethylethylenediamine (TEMED) as accelerator, each reagent added was mixed uniformly by magnetic stirring. React at a low temperature of 4°C for 1 hour to obtain a transparent bulk hydrogel. The product has high transparency and a light transmittance greater than 90%; it has two characteristic fluorescence peaks at 508nm and 579nm; its swelling ratio is 73.7%; and it can still return to its original state after being subjected to a pressure of 70Mpa.

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Abstract

The invention relates to the field of the environment sensitive type high polymer material, specifically to an inorganic fluorescent quantum dot-rhodamine composite block thermo sensitive hydrogel, and a preparation method thereof. The hydrogel is characterized in that: quantum dots and rhodamine are encapsulated in a thermo sensitive hydrogel to form the inorganic fluorescent quantum dot-rhodamine composite block thermo sensitive hydrogel. According to the present invention, a fluorescence resonance energy transfer system exists in the composite hydrogel provided by the present invention, such that the hydrogel can be adopted as a controlled-release drug carrier, and the hydrogel can be provided for tracing the drug.

Description

technical field [0001] The invention relates to the field of environment-sensitive polymer materials, in particular to an inorganic fluorescent quantum dot-rhodamine composite bulk temperature-sensitive hydrogel and a preparation method thereof. Background technique [0002] Smart hydrogel materials are a class of hydrophilic polymers with a three-dimensional network structure that respond significantly to small changes or stimuli in the external environment (such as temperature, pH value, light, electricity, magnetism, specific biological signals, etc.). Among them, poly N-isopropylacrylamide (PNIPAM) hydrogel is a kind of temperature-sensitive material that has been widely studied. In 1984, Tanaka first reported the temperature-sensitive properties of the hydrogel, which is characterized by the existence of a temperature Low critical phase transition temperature (LCST) in the transition region. When the hydrogel is lower than this temperature, the gel swells, and the volum...

Claims

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Application Information

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IPC IPC(8): C08F220/54C08F222/38C08F2/44C08J3/075C09K11/06
Inventor 陈海燕顾月清张鑫崔思思曹洁
Owner CHINA PHARM UNIV
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