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Optical parameter reconstruction method based on frequency-domain near-infrared photoelasticimetry

An optical parameter, near-infrared light technology, applied in diagnostic recording/measurement, medical science, electronic digital data processing, etc. The effect of high fitting accuracy

Inactive Publication Date: 2010-10-13
TIANJIN UNIV
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Problems solved by technology

However, the diffuse approximation is not very accurate in solving the problem of light transport in complex geometric models such as cervical tissue (4，5) , there is no advantage

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  • Optical parameter reconstruction method based on frequency-domain near-infrared photoelasticimetry
  • Optical parameter reconstruction method based on frequency-domain near-infrared photoelasticimetry
  • Optical parameter reconstruction method based on frequency-domain near-infrared photoelasticimetry

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Embodiment Construction

[0031] The invention provides a tissue optical parameter reconstruction method. Considering that the research object of the present invention is a biological tubular tissue with complex geometry and special boundary conditions, such as hollow cylindrical cervical tissue, the present invention selects the MC model as the forward model describing the propagation process of light in the tissue to obtain a more accurate simulation results.

[0032] Since it is known that the description of optical parameters of tissue is the basis of light transmission in biological tissue, the forward transmission model of light in tissue is the basis of the inversion problem of tissue optical parameters, that is, the inverse problem.

[0033] The solution of the forward model is a process that requires multiple calculations in the optical parameter inversion. It is difficult to give the inversion results in real time. Therefore, it is particularly important to quickly and accurately obtain the...

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Abstract

The invention belongs to the field of optical parameter measurement in tissue optics research, in particular to an optical parameter reconstruction method based on frequency-domain near-infrared photoelasticimetry. The optical parameter reconstruction method comprises the following steps of: positively modeling by utilizing a time-domain Monte Carlo simulated biological tissue model; and extracting frequency-domain information by utilizing a fast formula; acquiring frequency-domain information under any optical parameter by adopting a rapid MC (Multiple-Carrier) module based on a binary polynomial to achieve the aim of accurately reconstructing the optical parameters of tubular tissue by integrating an L-M (Levenberg-Marquardt) optimization algorithm and improve the reconstruction accuracy by introducing a cluster analysis method. The invention has the advantages of simultaneously reconstructing an absorption coefficient and a scattering coefficient of tissue and reconstructing the speed and the accuracy and can be used for accurately predicting the optical parameters of a measured sample in real time by the measured frequency-domain information, i.e. the amplitude and the phase (A, phi).

Description

technical field [0001] The invention belongs to the field of optical parameter measurement in tissue optics, in particular to an optical parameter reconstruction method based on frequency-domain near-infrared light measurement. technical background [0002] In recent years, the incidence of cervical cancer has increased, seriously threatening women's health. A large number of studies have shown that early and timely diagnosis is crucial for the treatment of cervical cancer. [0003] As a new diagnostic method for early cervical cancer, near-infrared optical method has the advantages of non-invasive, rapid and accurate measurement compared with traditional detection methods. It passes the optical parameters of biological tissue (including the absorption coefficient μ a and the scattering coefficient μ s ) to provide a reliable basis for disease diagnosis. [0004] The near-infrared measurement methods of biological tissue optical parameters are mainly divided into continu...

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Application Information

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IPC IPC(8): A61B5/00G06F19/00
Inventor 赵会娟张书颖周晓青王婷婷高峰
Owner TIANJIN UNIV
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