Method for effectively treating varicocele by morida officinalis polysaccharide extracts through inhibiting testis blood vessel generation

Abstract

The invention discloses a method for effectively treating varicocele by morida officinalis polysaccharide extracts through inhibiting testis blood vessel generation. The method comprises the followingsteps of (1) building an experimental varicocele animal model; (2) extracting morida officinalis coarse polysaccharide; performing primary purification; then, studying and discussing the restorationeffect of the morida officinalis coarse polysaccharide on the experimental varicocele rat hypothalamus-pituitary gland-testis axis, particularly the restoration effect in the early stage and developing stage of the disease; (3) obtaining a result showing that 100mg / kg of morida officinalis coarse polysaccharide can restore the double-side testis sperm production function and epididymal sperm quality in the early stage of the varicocele; the mechanism can be relevant to the angiogenesis inhibition and interstitial tissue normal metabolism maintenance. The sperm production function of a subclinical or varicocele early-stage patient can be improved; the progressive lesion of the testis interstitial tissue and blood vessels can be inhibited.

Description

technical field [0001] The invention relates to a method for treating varicocele, in particular to a method in which Morinda officinalis polysaccharide extract effectively treats varicocele by inhibiting testicular angiogenesis. Background technique [0002] Currently, there are 10%–15% of infertile couples in the world, of which male causes account for 45%–55%. Male infertility is mainly divided into primary infertility and secondary infertility. Primary infertility refers to a man who has never impregnated a woman, and secondary infertility refers to a man who has impregnated a woman but has not been able to conceive the woman after living together for a year. Varicocele accounts for 40% of the causes of primary male infertility and 71% of the causes of secondary infertility. It is the main cause of known male infertility. [0003] Varicocele is a vascular disease caused by dilation and tortuosity of the spermatic vein and varicocele plexus. It is more likely to occur on...

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Problems solved by technology

However, the effect of postoperative restoration of reproductive function is not very satisfactory, and the recurrence rate is as high as 5%–14%.

In addition, for adolescent patients whose gonads are still developing, varicocele resection may not be conducive to the repair and protection of bilateral testes

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