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Application of vitexin in preparation of medicine for treating diabetes sexual function and hypofertility

A technology of diabetes and vitexin, applied in the direction of drug combination, disease, pharmaceutical formula, etc., can solve the problem of reducing

Active Publication Date: 2021-02-26
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that oral administration of vitexin significantly reduced postprandial blood glucose in sucrose-loaded renal hyperglycemic mice and STZ-induced diabetic rats, suggesting a potential anti-diabetic effect of vitexin, but there is little information about the effect of vitexin on the reproduction of diabetic patients. The research on the impact of the system has not been reported in the literature

Method used

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  • Application of vitexin in preparation of medicine for treating diabetes sexual function and hypofertility
  • Application of vitexin in preparation of medicine for treating diabetes sexual function and hypofertility
  • Application of vitexin in preparation of medicine for treating diabetes sexual function and hypofertility

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Vitexin is used in the preparation of medicines for treating diabetes mellitus and hypofertility. The structural formula of vitexin is shown in formula (1):

[0040]

[0041] Formula 1).

[0042] Among them, the single application dose of vitexin is limited to the dose that does not cause central nervous system inhibition, the single application dose of vitexin is 10 mg / kg for ICR mice, and the dosage form of the drug is a solution dosage form.

Embodiment 2

[0044] Vitexin is used in the preparation of medicines for treating diabetes mellitus and hypofertility. The structural formula of vitexin is shown in formula (1):

[0045]

[0046] Formula 1).

[0047] Among them, the single application dose of vitexin is limited to the dose that does not cause central nervous system inhibition, the single application dose of vitexin is 20mg / kg for ICR mice, and the dosage form of the drug is injection powder.

Embodiment 3

[0049] Vitexin is used in the preparation of medicines for treating diabetes mellitus and hypofertility. The structural formula of vitexin is shown in formula (1):

[0050]

[0051] Formula 1).

[0052] Among them, the single application dose of vitexin is limited to the dose that does not cause central nervous system inhibition, the single application dose of vitexin is 40mg / kg for ICR mice, and the dosage form of the drug is injection powder.

[0053] The following animal experiment has further illustrated the effect of above-mentioned embodiment 1 to 3:

[0054] 1. Experimental materials

[0055] 1.1 Animal handling

[0056] 9-week-old, ICR mice, 25-30 g, were purchased from the Experimental Animal Center of Ningxia Medical University, animal production license number: NCXK (Ning) 2013-0005. They were raised in an SPF grade barrier system, the room temperature was maintained at (22±2)°C, the humidity was 40-60%, and the daily light and dark time were 12 hours each. T...

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Abstract

The invention discloses application of vitexin in the preparation of drugs for treating diabetic sexual dysfunction and reproductive dysfunction. An experimental result of the invention indicates thatwhen used within a safe dose range, vitexin, the dose of which is 40 mg / kg, can notably improve diabetic body quality, reproductive organ weight reduction, low sperm motility and survival rate, serumendocrine hormone disorder, sexual dysfunction, reproductive dysfunction and the like, proving that vitexin has the effect of preventing diabetic sexual dysfunction and reproductive dysfunction.

Description

technical field [0001] The invention relates to the application of vitexin, in particular to the application of vitexin in the preparation of medicines for treating diabetes mellitus and hypofertility. Background technique [0002] Diabetes mellitus is one of the world's major health problems, characterized by hyperglycemia due to defects in insulin secretion and / or insulin action, which has become the ninth leading cause of death. The International Diabetes Federation (IDF) estimates that in 2017, there were 451 million people (18-99 years) living with diabetes worldwide, and by 2045 these numbers are expected to rise to 693 million. Diabetes-related sexual dysfunction and subfertility and / or infertility are major secondary complications in diabetic animals and humans compared with non-diabetic patients. About 90% of diabetic patients have sexual dysfunction, including decreased libido, impotence, and infertility; at the same time, in the diabetic animal model induced by s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P3/10A61P15/08
CPCA61K31/352A61P3/10A61P15/08
Inventor 余建强李志梅刘宁吴璟李玉香
Owner NINGXIA MEDICAL UNIV
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