Medicinal composition containing nitrate esters for treating ventricular hypertrophy or myocardial fibrosis
A technology of myocardial fibrosis and nitrate ester, applied in the new field of western medicine, can solve problems such as heart failure, sudden death, dilated cardiomyopathy, etc., and achieve the effect of easy acceptance, strong operability, and simple administration route
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Embodiment 1
[0015] Inhibitory effect of isosorbide mononitrate on hypertensive myocardial hypertrophy in DOCA-salt type rats
[0016] The DOCA-salt type rat hypertensive myocardial hypertrophy model belongs to the endocrine hypertensive hypertrophy model, which is the low renin type. Add saline to deoxycorticosterone to form a volume overload hypertensive myocardial hypertrophy model.
[0017] 1. Experimental materials
[0018] 1.1 Drugs Isosorbide Mononitrate (Lunan Pharmaceutical Co., Ltd.) Sodium Chloride (Tianjin Shentai Chemical Co., Ltd. Batch Number 20040318 Specification 500g Analytical Pure) Normal Saline (Binzhou Pharmaceutical Factory Batch Number 04111304 Specification 500ml) Nifedipine (Surabaya Xierkang Pharmaceutical Co., Ltd. Batch No. 200410224 Specification 10mg·100 tablets)
[0019] 1.2 Instrument Sartorius Analytical Balance (Beijing Sartorius Instrument System Co., Ltd.) Electronic Scale (Shanghai Dahua Electronic Scale Factory)
[0020] 1.3 Animals SD rats, clean g...
Embodiment 2
[0033] Inhibitory effect of nitroglycerin on myocardial hypertrophy induced by L-thyroxine
[0034] Large doses of L-thyroxine can promote the synthesis of mRNA and protein in cardiomyocytes, thereby making cardiac muscle hypertrophy. ATP depletion increases oxygen consumption and decreases the density of myocardial capillaries, thereby increasing the distance for oxygen to diffuse from capillaries to the center of myocardial cells. Therefore, myocardial hypertrophy is prone to ischemia, and there are scattered ischemic lesions.
[0035] 1. Experimental materials
[0036]1.1 Nitroglycerin (Beijing Yimin Pharmaceutical Co., Ltd. batch number 20050607 specification 5mg / tablet) sodium carboxymethyl cellulose (Sinopharm Chemical Reagent Co., Ltd. batch number F20050302 specification 500g chemically pure) L-thyroxine sodium tablet (Germany Merck company batch number 3600601 specification 50 μg / tablet) MDA kit and SOD kit were purchased from Nanjing Jiancheng Institute of Bioengine...
Embodiment 3
[0058] Inhibitory effect of isosorbide dinitrate on stress-induced hypertension model in rats
[0059] Rat models of stress-induced hypertension were prepared by cold water stimulation combined with noise stress stimulation. The occurrence of stress hypertension is the result of the interaction of many factors in the body. For example, during the stress process, the renin-angiotensin system (RAS) function is hyperactive, the sympathetic tension increases, the adrenal medulla releases adrenaline and norepinephrine, etc., and some substances that have an antagonistic effect on the above functions An exception occurred in the synthesis or release of .
[0060] 1. Experimental materials
[0061] 1.1 Drug Isosorbide Dinitrate Sustained-release Capsules (self-made) absolute ethanol (Qingdao Haibin Chemical Reagent Factory, batch number 200511019, specification 500ml analytically pure)
[0062] 1.2 Instrument Sartorius Analytical Balance (Beijing Sartorius Instrument System Co., L...
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