Coating method for improving surface of interventional device

A device and coating technology, applied in the field of improving the coating on the surface of interventional devices, can solve problems such as affecting the biological properties of the device, deformation of the device surface, affecting product quality, etc., and achieve excellent biocompatibility, reduced damage, and good targets. effect on delivery

Active Publication Date: 2017-07-11
科睿驰(深圳)医疗科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since polyurethane is dissolved in a volatile organic solvent, if it is directly coated on the surface of a medical device made of polymer material, it will cause surface damage, and after the top layer solution is quickly cured, part of its solvent will be absorbed by the polymer interventional device, resulting in solvent residues , affect the biological performance of the device, and seriously dissolve the surface of the interventional device to deform it, affecting product quality

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] 1. Materials

[0052] 1. Bottom layer solution: add 10 grams of polyvinyl alcohol to 100 ml of deionized water, heat at 70°C to 80°C, stir at a constant speed, after the polyvinyl alcohol is completely dissolved, lower the solution to room temperature while stirring.

[0053] 2. Top layer solution: add 10 grams of polyurethane to 100 ml of dioxane solvent, add 0.5 ml of Tween 80, stir and dissolve to obtain a liquid polyurethane solution; to obtain 100 ml of liquid polyurethane solution, add 10 grams of polyvinylpyrrolidone , and then add 0.5 ml of Tween 80, and stir at a constant speed at room temperature until the polyvinylpyrrolidone is dissolved.

[0054] 2. Method

[0055] 1. Immerse the interventional device (catheter) in the underlying solution slowly, stably, and at a constant speed. After the surface is coated with the underlying solution, the interventional device is lifted out of the underlying solution in the same operation mode, and the first curing treatm...

Embodiment 2

[0060] 1. Materials

[0061] 1. Bottom layer solution: add 5 grams of polyvinyl alcohol to 100 ml of deionized water, heat at 70°C to 80°C, stir at a constant speed, and after the polyvinyl alcohol is completely dissolved, lower the solution to room temperature while stirring.

[0062] 2. Top layer solution: Add 8 grams of polyurethane to 100 milliliters of dioxane solvent, add 0.2 milliliters of Tween 80, stir and dissolve to obtain a liquid polyurethane solution; obtain 100 milliliters of liquid polyurethane solution, add 5 grams of polyvinylpyrrolidone , and then add 0.5 ml of Tween 80, and stir at a constant speed at room temperature until the polyvinylpyrrolidone is dissolved.

[0063] 2. Method

[0064] 1. Immerse the interventional device (thrombosis suction tube) slowly, stably, and at a constant speed in the underlying solution, and after coating the surface with the underlying solution, lift the interventional device out of the underlying solution in the same operat...

Embodiment 3

[0069] 1. Materials

[0070] 1. Bottom layer solution: add 15 grams of polyvinyl alcohol to 100 ml of deionized water, heat at 70°C to 80°C, stir at a constant speed, and after the polyvinyl alcohol is completely dissolved, lower the solution to room temperature while stirring.

[0071] 2. Top layer solution: add 9 grams of polyurethane to 100 milliliters of dioxane solvent, add 2 milliliters of Tween 80, stir and dissolve to obtain a liquid polyurethane solution; obtain 100 milliliters of liquid polyurethane solution, add 20 grams of polyvinylpyrrolidone , and then add 0.5 ml of Tween 80, and stir at a constant speed at room temperature until the polyvinylpyrrolidone is dissolved.

[0072] 2. Method

[0073] 1. Immerse the interventional device (drainage tube) slowly, stably, and at a constant speed into the underlying solution, and after the surface is coated with the underlying solution, lift the interventional device out of the underlying solution in the same operation mo...

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PUM

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Abstract

The invention relates to a coating method for improving the surface of an interventional device, belonging to the technical field of manufacturing of medical apparatuses and instruments. The coating method for improving the surface of the interventional device comprises the following steps: coating the surface of the interventional device with a bottom-layer solution and carrying out primary curing; and then coating the surface of the interventional device with a top-layer solution and carrying out secondary curing. The coating method provided by the invention has the following advantages: the coating solutions are simple in formula, easy to prepare and apply, safe and reliable; and a coating with excellent biocompatibility and hydrophilicity is provided for the interventional device, and the surface of the high-molecular interventional device is protected from damage by organic solvents and organic solvent residues in the process of preparation. The interventional device with the surface improved by using the method can smoothly pass through the blood vessels, non-blood-vessel passages and the like of a human body, so damage of the device to vessel walls is reduced and good targeted delivery is realized.

Description

technical field [0001] The invention relates to a coating method for improving the surface of an interventional device, which belongs to the technical field of medical device manufacturing. Background technique [0002] Percutaneous puncture (percutaneous puncture technique) is the basis of interventional radiology. Its purpose is to establish channels, including vascular and non-vascular channels. Most interventional techniques must complete the diagnosis and treatment process through this channel, so that the delivery device can reach Lesions targeted to achieve the purpose of precise treatment. [0003] To establish vascular and non-vascular channels in the human body, polymer tubes are usually used to percutaneously puncture and delivered to the targeted parts of the human body along the guide wire. Devices, drugs, and implants are then delivered to the lesion through the inside of the polymer tube. The outer layer of the polymer tubing is coated with a hydrophilic mate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L29/08A61L29/14A61L31/14B05D3/06B05D3/02B05D7/00
CPCA61L29/085A61L29/148A61L31/10A61L31/148A61L2420/06A61L2420/08B05D1/38B05D3/0263B05D3/067B05D7/546B05D2451/00B05D2503/00B05D2518/00C08L39/06C08L75/04C08L29/04B05D2401/20B05D2401/10B05D2420/01B05D2420/02
Inventor 车海波蔡杰萍
Owner 科睿驰(深圳)医疗科技发展有限公司
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