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Gadolinium-containing silicon dioxide nanosphere magnetic resonance contrast agent and preparation method thereof

A magnetic resonance contrast agent, silicon dioxide technology, applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agent, emulsion delivery, drug delivery, etc., can solve poor particle size distribution control, limit the application of contrast agents, and irregular morphology problems such as high particle size uniformity, regular shape, and reduced gadolinium content

Inactive Publication Date: 2010-06-23
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In terms of preparing gadolinium-containing silica composite materials, the patent publication number CN1692947 discloses a nanocomposite preparation method of gadolinium-doped silica, using method, silica nanoparticles are formed in an alkaline solution mixed with GdCl3, and a rod-shaped particle with a particle size of 20-150 nm is prepared, but its shape is irregular, the dispersion is poor, and the particle size distribution is less controlled. Poor, and low encapsulation efficiency, which limits its application as a developer

Method used

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  • Gadolinium-containing silicon dioxide nanosphere magnetic resonance contrast agent and preparation method thereof
  • Gadolinium-containing silicon dioxide nanosphere magnetic resonance contrast agent and preparation method thereof
  • Gadolinium-containing silicon dioxide nanosphere magnetic resonance contrast agent and preparation method thereof

Examples

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Effect test

Embodiment 1

[0033] Example 1: Mix 7.5ml of oil phase cyclohexane and 1.8ml of surfactant polyethylene glycol octyl phenyl ether (Triton X-100), and stir vigorously until uniform, and then add 150μl of gadopentetate dimethylglucoside After the amine solution (469.01mg / ml) and 240μl of ammonia (25wt%) are mixed uniformly, they are slowly dropped into the oil phase under ultrasonic and stirring conditions of 400rpm, and the ultrasonic stirring is continued for 30 minutes until the microemulsion is formed. Under stirring at a speed of 400 rpm, slowly add 100 μl of ethyl orthosilicate (TEOS), and continue stirring for 3 hours. The microemulsion system was placed in the backlight and aged at room temperature for 24 hours. After the reaction is complete, add acetone to demulsify, centrifuge at high speed and discard the supernatant, then wash with absolute ethanol for at least 5 times, ultrasonically disperse in deionized water, freeze-dried to obtain the water-soluble doped gadolinium preparatio...

Embodiment 2

[0034] Example 2: Mix 10ml of oil phase liquid paraffin, 100μl of surfactant sorbitol stearate (Span80), and stir vigorously until uniform, then add 10μl of gadoterate meglumine solution (50mg / ml) and 50μl of hydrogen After the sodium oxide solution (5wt%) is uniformly mixed, it is slowly dropped into the oil phase under ultrasonic and stirring conditions of 100 rpm, and ultrasonic stirring is continued for 30 minutes until the microemulsion is formed. Under stirring at a speed of 100 rpm, 50 μl of ethyl orthosilicate (TEOS) was slowly added, and stirring was continued for 3 hours. The microemulsion system was placed in the backlight and aged at room temperature for 24 hours. After the reaction is complete, add acetone to demulsify, centrifuge at high speed and discard the supernatant, then wash with absolute ethanol for at least 5 times, and then ultrasonically disperse in deionized water to obtain water-soluble silica doped with gadolinium preparation Nano microsphere suspen...

Embodiment 3

[0035] Example 3: Mix 10ml of oil phase petroleum ether, 4ml of surfactant sorbitol stearate (Span80), and stir vigorously until uniform, then mix 800μl of Gd-DTPA chelate solution (1000mg / ml) and 1ml of hydrogen After the sodium oxide solution (30 wt%) is uniformly mixed, it is slowly dropped into the oil phase under ultrasonic and stirring conditions of 500 rpm, and ultrasonic stirring is continued for 30 minutes until the microemulsion is formed. Under stirring at a speed of 500 rpm, slowly add 1 ml of ethyl orthosilicate (TEOS) and continue stirring for 3 hours. The microemulsion system was placed in a dark place and aged at room temperature for 48 hours. After the reaction is complete, add acetone to demulsify, centrifuge at high speed and discard the supernatant, then wash with absolute ethanol for at least 5 times, ultrasonically disperse in deionized water, freeze-dried to obtain the water-soluble doped gadolinium preparation Silica nano-sphere powder.

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Abstract

The invention relates to a gadolinium-containing silicon dioxide nanosphere magnetic resonance contrast agent for lymphatic system specific imaging and a preparation method thereof. The contrast agent is nanosphere suspend liquid or powder formed by using water-soluble silicon dioxide to cover preparation containing gadolinium, wherein the particle size ranges from 50nm to 200nm; the weight ratio of the preparation containing gadolinium to the water-soluble silicon dioxide is between 1.86X10<-4> and 0.592. The nanosphere prepared by the invention has relatively high entrapment efficiency, can selectively enter Lymphatic capillaries but not capillary vessel, thereby being used for the lymphatic system specific imaging, reducing the interference of the capillary vessel, improving the sensitivity and specificity of the lymphatic qualitative diagnosis, as well as reducing the harm thereof to human body, therefore, the nanosphere magnetic resonance contrast agent is a new gadolinium-containing magnetic resonance contrast agent with high target.

Description

Technical field: [0001] The invention relates to a novel gadolinium-containing magnetic resonance contrast agent and a preparation method thereof, in particular to a water-soluble silica nano-microsphere contrast agent doped with a gadolinium preparation for specific imaging of the lymphatic system and a preparation method thereof. Background technique: [0002] With the development of micro-lymphatic surgery technology, higher requirements are put forward for the classification and location diagnosis of lymphatic drainage disorders; at the same time, it can display the structure of lymphatic vessels and lymph nodes more accurately and sensitively, and judge their functional status. Accurate staging of cancer patients is the basis for formulating treatment plans, judging prognosis, effectively preventing postoperative lymphedema, and is the key to diagnosis and treatment of lymphatic system diseases. Lymphography has always been regarded as the "gold standard" for imaging the str...

Claims

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Application Information

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IPC IPC(8): A61K49/08A61K49/06A61K49/18
Inventor 胡劲刘晓晟沈新程许建荣金彩虹何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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