A whitening and repairing composition suitable for sensitive skin and application thereof
Patent Information
- Application Number
- CN202610840752.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-06-11
- Publication Date
- 2026-07-17
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Abstract
Description
Technical Field
[0001] This invention belongs to the field of cosmetic technology, specifically relating to a whitening and repairing composition suitable for sensitive skin and its application. Background Technology
[0002] With improved living standards and increased skincare awareness, skin whitening has become a core demand in the skincare industry. This is especially true for people with sensitive skin, who have an increasingly urgent need for whitening products that combine safety and effectiveness. However, sensitive skin has a weaker skin barrier function and lower tolerance to external stimuli. While high-concentration whitening ingredients commonly found in regular whitening products (such as Vitamin C, niacinamide, and 377) do have some whitening effect, they can easily irritate sensitive skin, causing redness, stinging, itching, and other discomforts, and even exacerbating existing sensitivity issues, creating a dilemma of "irritation upon use, and rebound darkening upon discontinuation."
[0003] Currently, most skin whitening products for sensitive skin on the market adopt a "single soothing + single whitening" formulation model, which has problems such as unsatisfactory whitening effects, poor synergy between soothing and whitening, and a high risk of sensitization. On the one hand, a single whitening ingredient cannot inhibit melanin production along the entire pathway; it can only act on a certain stage of melanin production, resulting in limited effects and a tendency for rebound pigmentation due to external stimuli. On the other hand, a single soothing ingredient cannot comprehensively alleviate the irritation caused by whitening ingredients, nor can it effectively repair the damaged skin barrier of sensitive skin. Therefore, it cannot address the core pain points of skin whitening for sensitive skin at their root.
[0004] Therefore, developing a whitening and repairing composition with natural plant extracts as the main active ingredients, which can achieve a synergistic effect of gentle whitening and soothing repair, significantly reduce the risk of allergies, and effectively meet the needs of people with sensitive skin, has important practical significance and broad market prospects. Summary of the Invention
[0005] To address the problems of high irritation risk, poor synergy between whitening and soothing effects, and limited efficacy of existing whitening products for sensitive skin, this invention provides a whitening and repairing composition suitable for sensitive skin. The composition uses white chrysanthemum flower extract, mimosa flower extract, and hibiscus flower extract as the main active ingredients. The three work synergistically to achieve a gentle and effective whitening effect, while also soothing, anti-allergic, and repairing the skin, reducing the risk of sensitization, making it suitable for people with sensitive skin.
[0006] To achieve the above objectives, the present invention adopts the following technical solution: In a first aspect, the present invention provides a whitening and repairing composition suitable for sensitive skin, wherein, by weight, the main active ingredients include: 3-8 parts of white chrysanthemum flower extract, 6-12 parts of mimosa flower extract, and 5-10 parts of hibiscus flower extract.
[0007] Furthermore, to optimize the synergistic effect, the preferred ratio of the main active ingredients is: 5-7 parts of white chamomile flower extract, 8-10 parts of mimosa flower extract, and 6-8 parts of hibiscus flower extract. Under this ratio, the efficacy of the three extracts can be more fully realized, resulting in a stronger synergistic effect of whitening and soothing repair.
[0008] Secondly, the present invention provides a method for preparing the whitening and repairing composition for sensitive skin described in the first aspect, wherein extracts of white chrysanthemum, mimosa, and hibiscus are mixed and passed through a 60-200 mesh sieve to obtain the product.
[0009] Preferably, the extracts of white chrysanthemum, mimosa, and hibiscus are mixed and passed through an 80-120 mesh sieve to obtain the final product.
[0010] Thirdly, the present invention provides a cosmetic containing the whitening and repairing composition for sensitive skin described in the first aspect. The amount of the whitening and repairing composition for sensitive skin added to the cosmetic is 0.1-8 wt%. Preferably, the amount of the whitening and repairing composition for sensitive skin added to the cosmetic is 0.5-5 wt%.
[0011] Furthermore, the cosmetic also includes cosmetic excipients, including emollients, emulsifiers, thickeners, humectants, antioxidants, pH adjusters, and fragrances.
[0012] Fourthly, the present invention provides the use of the whitening and repairing composition for sensitive skin described in the first aspect or the whitening and repairing composition for sensitive skin prepared by the method described in the second aspect in the preparation of cosmetics.
[0013] The whitening and repairing composition suitable for sensitive skin is added to cosmetics in an amount of 0.1-8 wt%.
[0014] The cosmetic product is any one of the following: serum, toner, essence lotion, facial mask liquid, or cream.
[0015] The cosmetics also include cosmetic excipients, including emollients, emulsifiers, thickeners, humectants, antioxidants, pH adjusters, and fragrances.
[0016] The moisturizer is preferably at least one of sodium hyaluronate, glycerin, panthenol, 1,3-propanediol, butylene glycol, and 1,2-hexanediol, which can enhance the skin's moisturizing ability and help repair the skin barrier; the thickener is preferably at least one of carbomer and xanthan gum, which is used to adjust the viscosity of the composition and improve the user experience; the emollient is preferably at least one of caprylic / capric triglyceride, polydimethylsiloxane, and cetearyl alcohol; the emulsifier is preferably at least one of cocoyl glucoside, polyglycerol-10 oleate, and sodium stearoyl glutamate; the antioxidant is p-hydroxyacetophenone; the fragrance is preferably a natural plant fragrance to reduce irritation to sensitive skin; and the pH adjuster is selected from natural amino acids, preferably arginine.
[0017] White chamomile flower extract is a classic, gentle, soothing, and repairing active ingredient in cosmetics, rich in α-bisabolol, chamomile azulene, and flavonoids. Its core advantage lies in its powerful anti-inflammatory and soothing properties, effectively inhibiting the release of inflammatory factors and histamine, quickly improving skin redness, stinging, itching, and other sensitive discomforts, repairing the damaged skin barrier, and enhancing skin tolerance. It also possesses excellent antioxidant and gentle whitening abilities, scavenging free radicals, inhibiting tyrosinase activity, reducing melanin production and post-inflammatory hyperpigmentation, and brightening and evening out skin tone.
[0018] Albizia flower extract is a natural plant-based active ingredient that focuses on anti-glycation and rhythm repair, primarily containing albizia glycosides, flavonoids, and polysaccharides. Unlike conventional whitening ingredients, its core function is to inhibit the formation of advanced glycation end products (AGEs) in the skin, improving dullness, roughness, and sagging caused by glycation, restoring a clear and radiant complexion. It also effectively repairs the skin's circadian rhythm, improving skin condition disruptions and barrier fragility caused by lack of sleep and external stress, enhancing the skin's self-repairing ability. While possessing gentle antioxidant and soothing anti-inflammatory properties, its direct melanin-inhibiting ability is relatively weak, but it can help brighten skin tone and stabilize skin condition, making it suitable for gentle anti-aging and brightening skincare systems for sensitive skin.
[0019] Hibiscus flower extract is a natural flower extract that combines powerful antioxidant and highly effective whitening properties. It is rich in highly active anthocyanins, anthocyanins, and polyphenols. This ingredient boasts outstanding antioxidant capabilities, effectively eliminating various free radicals in the skin, resisting photo-oxidative damage caused by UV rays and environmental pollution, delaying skin aging, and reducing oxidative dullness and pigmentation. Simultaneously, it significantly inhibits tyrosinase activity, blocking melanin synthesis at its source, reducing pigmentation induced by external stimuli, and providing excellent whitening and brightening effects. Furthermore, it possesses auxiliary anti-inflammatory and soothing effects, mildly improving skin redness and inflammation. Combined with soothing ingredients, it further reduces the irritation of the formula, making it suitable for use in gentle whitening and anti-aging products for sensitive skin.
[0020] Compared with the prior art, the present invention has the following beneficial effects: Significant synergistic whitening effect: This invention uses white chrysanthemum flower extract, mimosa flower extract, and hibiscus flower extract as the main active ingredients. The three work synergistically. White chrysanthemum flower extract inhibits melanin production at the source, achieving basic whitening; hibiscus flower extract, through its powerful antioxidant properties, eliminates free radicals and reduces pigmentation caused by external stimuli (such as ultraviolet rays and pollution), consolidating the whitening effect; mimosa flower extract, through its anti-glycation effect, improves dull skin and enhances skin tone brightness. The combination of the three achieves a full-pathway whitening effect of "melanin inhibition + antioxidant + anti-glycation", with a whitening effect superior to that of a single ingredient or a combination of two ingredients.
[0021] Gentle and hypoallergenic, suitable for sensitive skin: All three extracts have natural soothing and anti-inflammatory properties. White chamomile flower extract can directly soothe skin sensitivity and relieve discomfort such as redness and stinging; mimosa flower extract repairs the skin's biological rhythm and enhances the skin's own resistance; and hibiscus flower extract's antioxidant effect can reduce skin inflammation. The three work together to reduce the risk of irritation during the whitening process and significantly reduce the risk of allergies, solving the pain point of "easy irritation" in whitening for sensitive skin.
[0022] The composition of this invention not only has a whitening effect, but also repairs the damaged skin barrier of sensitive skin, enhances the skin's moisturizing ability and tolerance, and can improve the condition of sensitive skin with long-term use, achieving "whitening + repair" in one, avoiding the problem of further damage to the skin barrier caused by conventional whitening products that "only whiten but do not repair". Detailed Implementation
[0023] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. The described embodiments are only some preferred embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.
[0024] Unless otherwise specified, the experimental methods used in the embodiments are conventional or common methods in the art, and the materials and reagents used are commercially available unless otherwise specified.
[0025] The raw materials used in the examples and comparative examples are described below: White chrysanthemum extract: purchased from Shaanxi Wanzhiyuan Biotechnology Co., Ltd.; Albizia flower extract: purchased from Shaanxi Xintianyu Biotechnology Co., Ltd.; Roselle flower extract: purchased from Xi'an Feida Biotechnology Co., Ltd.
[0026] Unless otherwise specified, all components and raw materials used in the embodiments and comparative examples of this invention are commercially available, and the same type of components and raw materials are used in each parallel experiment.
[0027] The present invention will be further described in detail below with reference to specific embodiments and comparative examples. The following embodiments are for illustrative purposes only and are not intended to limit the scope of protection of the present invention.
[0028] Example 1 A whitening and repairing composition suitable for sensitive skin, comprising, by weight: 6 parts white chamomile flower extract, 9 parts mimosa flower extract, and 7 parts hibiscus flower extract. The above components are mixed and passed through a 100-mesh sieve to obtain the final product.
[0029] Example 2 A whitening and repairing composition suitable for sensitive skin, comprising, by weight: 5 parts white chamomile flower extract, 8 parts mimosa flower extract, and 8 parts hibiscus flower extract. The above components are mixed and passed through a 100-mesh sieve to obtain the final product.
[0030] Example 3 A whitening and repairing composition suitable for sensitive skin, comprising, by weight: 7 parts white chamomile flower extract, 10 parts mimosa flower extract, and 6 parts hibiscus flower extract. The above components are mixed and passed through a 100-mesh sieve to obtain the final product.
[0031] Example 4 A whitening and repairing composition suitable for sensitive skin, comprising, by weight: 8 parts white chamomile flower extract, 8 parts mimosa flower extract, and 5 parts hibiscus flower extract. The above components are mixed and passed through a 100-mesh sieve to obtain the final product.
[0032] Example 5 A whitening and repairing composition suitable for sensitive skin, comprising, by weight: 3 parts white chamomile flower extract, 6 parts mimosa flower extract, and 10 parts hibiscus flower extract. The above components are mixed and passed through a 100-mesh sieve to obtain the final product.
[0033] Example 6 A whitening and repairing composition suitable for sensitive skin, comprising, by weight: 5 parts white chamomile flower extract, 10 parts mimosa flower extract, and 5 parts hibiscus flower extract. The above components are mixed and passed through a 100-mesh sieve to obtain the final product.
[0034] Comparative Example 1 A whitening composition, by weight, comprises: 9 parts of Albizia julibrissin flower extract and 7 parts of Hibiscus rosa-sinensis flower extract. The above components are mixed and passed through a 100-mesh sieve to obtain the final product.
[0035] Comparative Example 2 A skin-whitening composition, by weight, comprises: 6 parts of white chamomile flower extract and 7 parts of hibiscus flower extract. The above components are mixed and passed through a 100-mesh sieve to obtain the final product.
[0036] Comparative Example 3 A skin-whitening composition, by weight, comprises: 6 parts of white chrysanthemum flower extract and 9 parts of mimosa flower extract. The above components are mixed and passed through a 100-mesh sieve to obtain the final product.
[0037] Comparative Example 4 A skin-whitening composition, by weight, comprises: 6 parts of white chamomile flower extract, 9 parts of mimosa flower extract, and 2 parts of hibiscus flower extract. The above components are mixed and passed through a 100-mesh sieve to obtain the final product.
[0038] Comparative Example 5 A skin-whitening composition, by weight, comprises: 15 parts of white chamomile flower extract, 5 parts of mimosa flower extract, and 15 parts of hibiscus flower extract. The above components are mixed and passed through a 100-mesh sieve to obtain the final product.
[0039] Comparative Example 6 A whitening composition, by weight, comprises: 6 parts purslane extract, 9 parts mimosa flower extract, and 7 parts hibiscus flower extract. The above components are mixed and passed through a 100-mesh sieve to obtain the final product.
[0040] Comparative Example 7 A skin-whitening composition, by weight, comprises: 6 parts of white chrysanthemum flower extract, 9 parts of salvia miltiorrhiza extract, and 7 parts of hibiscus flower extract. The above components are mixed and passed through a 100-mesh sieve to obtain the final product.
[0041] Technical effect verification test 1. Anti-inflammatory cell assay Experimental method: Human immortalized keratinocytes (HaCaT cells) were routinely revived and passaged, and cells in the logarithmic growth phase were used for subsequent experiments.
[0042] DMEM high-glucose complete culture medium (containing 10% fetal bovine serum and 1% penicillin-dextrose antibody), phosphate-buffered saline (PBS), 0.25% trypsin-EDTA digestion solution, lipopolysaccharide (LPS), NO detection kit, human IL-6 ELISA detection kit, and the compound sample to be tested.
[0043] Cell culture method: HaCaT cells were cultured in DMEM high-glucose complete medium under constant temperature and humidity conditions of 37℃, 5% CO2, and saturated humidity. After cell resuscitation, cells were routinely passaged, with the medium changed every 24-48 hours. When the cells reached the logarithmic growth phase and the confluence reached 70%-80%, they were digested with trypsin, centrifuged and resuspended, and the cell suspension concentration was adjusted for later use.
[0044] Cell plating and grouping for drug administration: Prepare HaCaT cell suspension (5×10⁻⁶ cells / mL) and administer the drug accordingly. 6The cells were evenly seeded into 24-well cell culture plates with a seeding volume of 100 μL per well. Each group was divided into 6 replicates (n=6). The plates were then incubated at 37°C in a 5% CO2 incubator for 24 h to allow the cells to adhere and grow fully.
[0045] After cell adhesion, the original culture medium was discarded. The experiment was divided into a blank group, a model group, and a sample group. The specific treatment methods are as follows: (1) Blank group: Add 500 μL of complete culture medium without LPS and without the test sample, culture normally, do not induce inflammation, and culture continuously in an incubator for 24 h; (2) Model group: Add 500 μL of complete culture medium containing a final concentration of 10 μg / mL LPS to construct an in vitro inflammation model of HaCaT cells. Do not add the test sample and incubate in an incubator for 24 h. (3) Sample group: First, add 500 μL of culture medium containing 10 μg / mL LPS and 15 μg / mL sample (the composition described in the examples and comparative examples) to treat the cells, and then place them in an incubator for continuous culture for 24 h.
[0046] Cell processing: After culturing for 24 hours, remove the 24-well plate, aspirate the cell supernatant from each well, transfer it to a sterile 1.5 mL centrifuge tube, centrifuge at 12000 r / min for 5 min to remove cell debris and impurities, collect the supernatant, and store it in an ultra-low temperature freezer at -80℃ for subsequent detection of NO and IL-6 levels.
[0047] Detection method: Strictly follow the instructions of the NO detection kit to detect the actual NO content (μmol / L) in the cell supernatant of each group, and take the average value of 6 replicates for each group.
[0048] The human IL-6 ELISA kit was used for detection, and the kit operation specifications were strictly followed. The IL-6 content (pg / mL) in the cell supernatant of each group was detected, and the average value was taken from 6 replicates of each group.
[0049] Based on the mean NO and IL-6 levels in each group, the inhibition rate of the samples against inflammatory factors was calculated using the following formula: NO inhibition rate (%) = (Mean NO value in model group - Mean NO value in sample group) / (Mean NO value in model group - Mean NO value in blank group) × 100%; IL-6 inhibition rate (%) = (mean IL-6 in model group - mean IL-6 in sample group) / (mean IL-6 in model group - mean IL-6 in blank group) × 100%.
[0050] Table 1 Inhibition rate of inflammatory factors Example 1 88.6% 82.2% Example 2 85.9% 79.8% Example 3 86.4% 80.4% Example 4 84.0% 77.2% Example 5 83.6% 76.5% Example 6 78.1% 71.3% Comparative Example 1 62.2% 56.8% Comparative Example 2 66.7% 60.2% Comparative Example 3 58.3% 52.7% Comparative Example 4 61.8% 55.9% Comparative Example 5 70.6% 64.0% Comparative Example 6 69.5% 62.5% Comparative Example 7 70.9% 64.1% According to the data in Table 1: 1) The NO inhibition rates of Examples 1-6 were all between 78% and 89%, and the IL-6 inhibition rates were between 71% and 83%, both significantly higher than all comparative examples (58.3%-70.9%, 52.7%-64.1%). 2) The NO inhibition rate of Comparative Example 1 (lacking Chrysanthemum indicum extract) was only 62.2%, the NO inhibition rate of Comparative Example 2 (lacking Albizia julibrissin extract) was only 66.7%, and the NO inhibition rate of Comparative Example 3 (lacking Roselle extract) was only 58.3%, all showing a significant decrease. Similarly, the IL-6 inhibition rates of Comparative Examples 1-3 also decreased significantly. 3) However, adjusting the proportions of each component in Comparative Examples 4-5 also resulted in a significant decrease in the anti-inflammatory effect compared to Example 1. However, in Comparative Examples 6 and 7, replacing Chrysanthemum indicum extract with Portulaca oleracea extract and Albizia julibrissin extract with Salvia miltiorrhiza extract, respectively, the anti-inflammatory effect was still significantly lower than that of Example 1. In summary, Examples 1-6 are superior to Comparative Examples 1-7, indicating that the ratio of the components in the examples is crucial for the synergistic effect of each component, and an imbalance in the ratio will reduce the anti-inflammatory efficiency. This demonstrates that the anti-inflammatory effect of the three extracts combined is significantly better than any combination of any two or the substitution of other plant extracts (such as purslane and salvia miltiorrhiza), indicating that the extracts of white chrysanthemum, albizia, and hibiscus in the embodiments of the present invention work synergistically and are indispensable.
[0051] 2. Antioxidant test The compositions described in Examples 1-6 and Comparative Examples 1-7 were subjected to DPPH free radical scavenging tests (n=5).
[0052] Experimental method: Add 4.0 mL of 1×10 to a 10 mL test tube sequentially. -4 Mix 0.5 mL of 0.01 g / mL deionized water (0.5 mL) of the same concentration as the sample with mol / L DPPH solution and seal with a sealing film. Shake well and immediately measure the absorbance A1 at 517 nm. React in the dark for 30 min and then measure the absorbance A2 at 517 nm. Add 4.0 mL of DPPH solution and 0.5 mL of sample dilution solvent (deionized water) to a test tube, shake well, and measure the absorbance value, which is recorded as A0.
[0053] DPPH free radical scavenging rate: Y = [1 - (A2 - A1) / A0] × 100%.
[0054] Table 2 DPPH free radical scavenging rate Example 1 91.1% Example 2 88.3% Example 3 88.9% Example 4 86.5% Example 5 85.2% Example 6 80.8% Comparative Example 1 65.7% Comparative Example 2 69.1% Comparative Example 3 62.0% Comparative Example 4 64.5% Comparative Example 5 73.3% Comparative Example 6 72.6% Comparative Example 7 73.0% According to the data in Table 2, Examples 1-6 exhibit extremely strong free radical scavenging capabilities. Example 1 showed a scavenging rate as high as 91.1%, while Examples 2-6 ranged from 80.8% to 88.9%, all within the highly effective antioxidant range. In contrast, Comparative Examples 1-7 showed scavenging rates of only 62.0%–73.3%, significantly lower than the Example groups. Comparative Example 3, lacking hibiscus flower extract, showed the largest decrease in scavenging rate at only 62.0%. Furthermore, Comparative Examples 4-5 showed a significant reduction in antioxidant capacity after altering the ratio of the active ingredients. Similarly, Comparative Examples 6 and 7 showed a significant decrease in antioxidant capacity after replacing components. These data indicate that the combination of chamomile flower extract, mimosa flower extract, and hibiscus flower extract can effectively scavenge free radicals and resist oxidative damage, thereby reducing oxidative dullness and pigmentation, and exhibiting a synergistic whitening effect.
[0055] Application examples Application Examples 1-6 and Comparative Application Examples 1-7 of the present invention provide a whitening skin care lotion, the components (mass percentage wt%) of which are shown in Table 3; wherein, Application Examples 1-6 and Comparative Application Examples 1-7 respectively use the compositions described in Examples 1-6 and Comparative Examples 1-7.
[0056] Table 3. Ingredients of Whitening Skin Lotion
[0057] Preparation process: S1. Mix each component of phase A with water and stir. Heat to 75°C and then homogenize at 6000 r / min for 3 min. After homogenization, keep warm for later use to obtain the pre-prepared phase A. S2. Mix the components of phase B, heat to 85°C until completely dissolved, keep warm for later use, and obtain the pre-prepared phase B; S3. Mix the components of phase C and heat to 55°C until completely dissolved to obtain the pre-prepared phase C; S4. Heat the pre-prepared phase A to 85°C, add the pre-prepared phase B, homogenize at 7000 r / min for 5 min, then cool to 50°C, add the pre-prepared phase C at 300 r / min and stir to mix, then cool to below 45°C and add the compositions corresponding to Examples 1-6 and Comparative Examples 1-7, continue stirring for 5 min, finally add arginine to adjust the pH, then stop stirring, discharge the material to obtain the whitening skin care lotion.
[0058] 1. Application example: Human patch test Test methods: In accordance with the "Cosmetic Safety Technical Specifications" (2015 edition), human patch tests were used to verify the irritation of sensitive skin in Examples 1-6 of this application. The specific test methods and the grading standards for adverse skin reactions are shown in Table 4.
[0059] Thirty volunteers were recruited, including 13 males and 17 females, aged 18-45 years, with an average age of 28.7 years. First, a suitable patch applicator was selected, and a closed patch test method was used. Approximately 25 μL of the test substance was placed in the patch applicator, which was then applied to the volunteer's arm with hypoallergenic adhesive tape. Gently pressing the tape ensured even application to the skin. The test substance was removed after 24 hours. Skin reactions were observed at 0.5, 24, and 48 hours after patch removal. Adverse skin reactions were recorded and are shown in Table 5.
[0060] Table 4. Grading Standards for Adverse Skin Reactions 0 negative reaction 1 The suspected reaction only showed faint erythema. 2 Weak positive reaction (erythema reaction); erythema, infiltration, edema, and papules may be present. 3 Strong positive reaction (herpes reaction); erythema, infiltration, edema, papules, vesicles; the reaction may extend beyond the test area. 4 Extremely strong positive reaction (confluent herpes simplex reaction); obvious erythema, severe infiltration, edema, confluent herpes simplex; reaction extends beyond the test area. Table 5. Results of adverse skin reactions
[0061] According to the test results in Table 5, this human patch test was conducted strictly in accordance with the "Cosmetic Safety Technical Specifications" (2015 edition). Through a closed skin patch test on 30 healthy volunteers aged 18-45, the potential irritation and sensitization of the skin care lotions (Examples 1-6) on human skin were systematically evaluated. In the test, an equal volume of 25 μL of the test sample was applied for 24 hours. Adverse skin reactions were continuously observed at 0.5 h, 24 h, and 48 h after removal of the patch applicator. The test timeline was complete and the observation period was sufficient, comprehensively reflecting the short-term irritation and delayed sensitization risks of the test samples on human skin.
[0062] The statistical results of adverse skin reactions show that, throughout the entire observation period, all volunteers in the test groups of Application Examples 1 to 6 had a skin reaction score of 0, indicating a negative reaction. None of the subjects experienced any skin irritation or allergic symptoms such as erythema, infiltration, edema, papules, or vesicles. There were no abnormal skin manifestations such as suspicious reactions, weak positives, or strong positives, indicating that none of the application examples produced skin irritation or sensitization reactions under the human closed patch conditions.
[0063] Further analysis based on the experimental results shows that the skin care compositions prepared by combining white chrysanthemum extract, mimosa flower extract, and hibiscus flower extract in Examples 1-6 of this invention are mild in nature and have excellent compatibility. After being applied to the skin, no irritating ingredients accumulate, and they do not cause damage or immune stimulation to the human epidermis.
[0064] In summary, the whitening skin lotions prepared in Examples 1-6 of this invention have no acute irritation to human skin, no risk of delayed sensitization, good safety, and are fully suitable for use on all types of skin, including sensitive skin, demonstrating excellent skin compatibility and safety in skincare applications.
[0065] 2. Application examples: human skin whitening and barrier repair experiments (1) The experiment was conducted in accordance with the human efficacy evaluation test method in the "Cosmetic Safety Technical Specifications" (2015 edition).
[0066] (2) Subject selection criteria: Asian adult female volunteers aged 33-50 who meet the following conditions: a) healthy volunteers with facial spots or dark facial skin; b) self-reported history of skin sensitivity (confirmed by a dermatologist); c) no history of serious systemic diseases or skin diseases.
[0067] Exclusion criteria: pregnant / lactating women, individuals with severe allergies, and individuals who have participated in other clinical trials within the past 3 months.
[0068] Number of participants: 65 qualified volunteers will be recruited and randomly divided into 13 groups of 5 people each.
[0069] (3) Test sample usage method: Take 1.5mL of the whitening skin care lotion prepared in Application Examples 1-6 and Comparative Application Examples 1-7. After cleansing their face in the morning and evening, volunteers should apply it evenly to their entire face and gently massage for 5 minutes. The test will continue for 28 days.
[0070] Preparation before testing: After the participants arrived, they cleaned their faces with a uniform, non-irritating facial cleanser and rested for 30 minutes in a constant temperature and humidity environment (temperature 25±1℃, humidity 60±10%) to avoid the influence of exercise on the test results.
[0071] (5) Test Indicators Whitening effect: Melanin Index: The melanin content of the skin is measured using a narrow-band reflectance spectrophotometer, and the melanin index is calculated. The lower the melanin index, the higher the skin whiteness.
[0072] Skin barrier repair effect: The TEWL value of the skin surface is measured using a skin moisture loss tester to assess the moisturizing function of the skin barrier. The lower the TEWL value, the better the skin barrier.
[0073] The facial skin condition was tested on the 14th and 28th days after product use to comprehensively evaluate the whitening efficacy and TEWL value of the product.
[0074] The formulas for calculating the evaluation parameters are as follows: Melanin index improvement rate = (Melanin index T0 - Melanin index Tn) / Melanin index T0 × 100%; where Tn = T 14 T 28 .
[0075] TEWL value improvement rate = (TEWL value T0 - TEWL value Tn) / TEWL value T0 × 100%; where Tn = T 14 T 28The experimental results are as follows.
[0076] Table 6 Results of Human Trials for Whitening and Repair Application Example 1 12.23% 17.78% 21.73% 30.97% Application Example 2 10.36% 17.11% 20.29% 28.34% Application Example 3 12.57% 18.30% 20.02% 29.45% Application Example 4 10.82% 16.87% 19.20% 28.07% Application Example 5 10.38% 15.18% 18.69% 26.29% Application Example 6 9.05% 13.04% 18.31% 25.12% Comparative Application Example 1 6.71% 8.80% 10.90% 15.61% Comparative Application Example 2 6.99% 10.16% 13.35% 17.53% Comparative Application Example 3 6.02% 7.52% 9.38% 12.36% Comparative Application Example 4 5.33% 8.13% 10.66% 13.89% Comparative Application Example 5 8.07% 9.52% 13.58% 16.23% Comparative Application Example 6 7.58% 9.50% 13.95% 16.92% Comparative Application Example 7 7.55% 10.21% 12.70% 17.79% According to the data in Table 6, this 28-day human efficacy trial targeted individuals with sensitive and dull skin, evaluating the whitening and barrier repair effects of the composition. The results showed that the whitening and repair capabilities of the application group were significantly superior to those of the control group. Regarding whitening, application example 1 showed an improvement rate of 12.23% and 21.73% in melanin index at 14 and 28 days, respectively; applications 2-6 showed improvement rates of 9.05%-12.57% at 14 days and 18.31%-20.29% at 28 days. In contrast, the improvement rate of the control group was only 5.33%-8.07% at 14 days and only 9.38%-13.95% at 28 days. The whitening effect of the application group at 28 days was approximately 1.3-2.3 times that of the control group. Regarding barrier repair, in Application Example 1, the TEWL value improvement rates were 17.78% and 30.97% at 14 and 28 days, respectively. Application Examples 2-6 showed improvements of 13.04%-18.30% at 14 days and 25.12%-29.45% at 28 days. In contrast, Application Example 1 showed an improvement rate of only 7.52%-10.21% at 14 days and only 12.36%-17.79% at 28 days. The barrier repair effect of Application Example 28 days was approximately 1.4-2.5 times that of the control group. Data shows that the whitening and barrier improvement effects continued to improve with prolonged use, proving that the composition possesses long-lasting, gentle whitening and barrier-strengthening capabilities. The synergistic effects of white chamomile extract, mimosa flower extract, and hibiscus flower extract can achieve multi-pathway effects of melanin inhibition, anti-oxidation, anti-glycation, and repair, effectively improving dullness, fragility, and easy pigmentation problems in sensitive skin. This avoids the drawbacks of conventional whitening products such as irritation, rebound pigmentation, and barrier damage, achieving an integrated whitening and repair effect.
[0077] The preferred embodiments of the present invention disclosed above are merely illustrative of the invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the invention to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of the invention, thereby enabling those skilled in the art to better understand and utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims
1. A whitening and repairing composition suitable for sensitive skin, characterized in that, By weight, the active ingredients include: 3-8 parts of white chamomile flower extract, 6-12 parts of mimosa flower extract, and 5-10 parts of hibiscus flower extract.
2. The whitening and repairing composition for sensitive skin according to claim 1, characterized in that, By weight, the active ingredients include: 5-7 parts of white chamomile flower extract, 8-10 parts of mimosa flower extract, and 6-8 parts of hibiscus flower extract.
3. The method for preparing the whitening and repairing composition suitable for sensitive skin according to claim 1 or 2, characterized in that, The extracts of white chrysanthemum, mimosa, and hibiscus are mixed and passed through a 60-200 mesh sieve to obtain the final product.
4. A cosmetic product, characterized in that, A whitening and repairing composition for sensitive skin as described in any one of claims 1-2.
5. The cosmetic product according to claim 4, characterized in that, The whitening and repairing composition suitable for sensitive skin is added to cosmetics in an amount of 0.1-8 wt%.
6. The cosmetic product according to claim 5, characterized in that, The whitening and repairing composition suitable for sensitive skin is added to cosmetics at a rate of 0.5-5 wt%.
7. The cosmetic product according to claim 4, characterized in that, The cosmetics also include cosmetic excipients, including emollients, emulsifiers, thickeners, humectants, antioxidants, pH adjusters, and fragrances.
8. Use of the whitening and repairing composition for sensitive skin according to any one of claims 1-2, or the whitening and repairing composition for sensitive skin prepared by the method of claim 3, in the preparation of cosmetics.
9. The use according to claim 8, characterized in that, The whitening and repairing composition suitable for sensitive skin is added to cosmetics in an amount of 0.1-8 wt%.
10. The use according to claim 8, characterized in that, The cosmetic product is any one of the following: serum, toner, essence lotion, facial mask liquid, or cream.