The invention belongs to the technical field of taVNS parameter adjustment, and relates to a taVNS closed-loop regulation and control method for high-
inflammation ARDS, and the method comprises the steps: obtaining a
neuron activation index through employing a dual-frequency auricular conchae impedance analysis technology, inputting the
time series data of the
neuron activation index into an
inflammation risk prediction model, obtaining an
inflammation risk
score, and achieving the quantitative evaluation of an inflammation state; in combination with a comparison result based on an inflammation risk
score and a set threshold value, a corresponding frequency control parameter is dynamically output in a multi-decision mode, and the current intensity is adjusted in combination with a real-time
neuron activation index, so that a
stimulation parameter can be adjusted in real time along with the change of an inflammation state; after stimulation is applied, by monitoring the neuron activation index change rate and the
heart rate variability high-
power index, the stimulation frequency is corrected within the preset time, a
closed loop of state
perception, parameter adjustment and effect feedback to parameter correction is formed, it is ensured that the stimulation parameters are accurately matched with the inflammation state all the time, and the stimulation effect is improved. Therefore, the target of dynamically adjusting parameters according to the inflammation state is achieved.