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Medicinal composition containing ibuprofen and arginine and preparation method and application thereof

A composition and technology of arginine, applied in the field of medicine, can solve problems such as increased production cost and cycle, slow progress in the development of liquid preparations, and limited solubility of ibuprofen

Inactive Publication Date: 2011-06-22
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the limited solubility of ibuprofen in water has slowed the development of its liquid formulations
At present, there are studies to combine ibuprofen with some basic amino acids (such as arginine) to make salts to increase its solubility, but after the salts are made, they need to be refined and then processed, which will significantly increase the preparation cost and cycle, and it is easy to introduce uncertain impurities in the process, increasing side effects

Method used

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  • Medicinal composition containing ibuprofen and arginine and preparation method and application thereof
  • Medicinal composition containing ibuprofen and arginine and preparation method and application thereof
  • Medicinal composition containing ibuprofen and arginine and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Embodiment 1 ibuprofen injection

[0008] prescription:

[0009] components

Dosage

ibuprofen

400g

arginine

338g

pH

7.4

Water for Injection

q.s 4000ml

Co-made

1000 bottles or 8000 bottles

[0010] Preparation:

[0011] Take about 3200ml of water for injection, add arginine, stir to dissolve, add Dexibuprofen, stir to dissolve, add water to 4000ml, filter, and pack into ampoules.

Embodiment 2

[0012] Embodiment 2 ibuprofen injection

[0013] prescription:

[0014] components

Dosage

ibuprofen

800g

arginine

676g

pH

7.4

Water for Injection

q.s 8000ml

Co-made

1000 bottles or 400 bottles

[0015] Preparation:

[0016] Take about 3200ml of water for injection, add arginine, stir to dissolve, add ibuprofen, stir to dissolve, add water to 4000ml, filter, and pack into ampoules.

Embodiment 3

[0017] Embodiment 3: Ibuprofen freeze-dried powder injection

[0018] prescription:

[0019]

[0020]

[0021] Preparation:

[0022] Take 1250ml of water for injection, add the prescribed amount of ibuprofen and arginine, stir and dissolve, adjust the pH value to 6.5-7.5 with hydrochloric acid solution and sodium hydroxide solution, add 0.1% active carbon for injection according to the prepared amount, and heat the liquid medicine to about Stir at 60°C for 20 minutes, filter and decarburize, add water for injection to the total amount, and detect intermediates. After the intermediates pass the test, fine filter with a 0.22 μm microporous membrane, fill in vials, place the vials in a freeze dryer, and freeze dry.

[0023] Freeze-drying conditions: Pre-freeze at -40°C for 4 hours, heat up to -10°C in the first stage for 2 hours, vacuum dry for 20 hours, heat up in the second stage from -10°C to 30°C within 1 hour, and keep warm for 4 Hour.

[0024] After freeze-drying,...

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PUM

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Abstract

The invention relates to a medicinal composition and a preparation method and application thereof. The medicinal composition is prepared from ibuprofen and arginine serving as medicinal active ingredients in a molar ratio of 1:1 and pharmaceutically acceptable auxiliary materials. The composition can be prepared into an oral preparation and an injection preparation for treating related symptoms such as fever, inflammation, pain and the like.

Description

technical field [0001] The invention relates to a medicinal composition containing ibuprofen and arginine, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] Ibuprofen is an effective PG synthase inhibitor with antipyretic, analgesic and anti-inflammatory effects. For sprains, strains, low back pain, frozen shoulder, bursitis, tendon and tenosynovitis. Toothache and postoperative pain, rheumatoid arthritis, osteoarthritis, and other seronegative (nonrheumatoid) joint diseases. It is used to relieve moderate pain, such as joint pain, muscle pain, migraine, headache, toothache, dysmenorrhea, neuralgia, and can also be used to relieve fever caused by the common cold or influenza. For a long time, the sales of ibuprofen in my country's pharmaceutical market have been growing steadily. Together with paracetamol, aspirin and diclofenac, it has become the four pillar products in my country's antipyretic and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K47/16A61P29/00
Inventor 王晓丹
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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