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Liniment for treating mouth and tooth diseases and applicator

A smear and tooth technology, which is applied in the field of external medicine smears and their applicators, can solve the problems of unsatisfactory curative effect, inconvenient use, short residence time and the like

Inactive Publication Date: 2011-09-28
广西星银迪智药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] But at present benzocaine is mainly applied as a unilateral drug, which is generally buccal tablet, aqueous preparation, paste or powder, and it is inconvenient to use, especially when it is used to treat diseases such as oral ulcers and gingival pain. Oral stay or stay time is short, the curative effect is not ideal

Method used

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  • Liniment for treating mouth and tooth diseases and applicator
  • Liniment for treating mouth and tooth diseases and applicator
  • Liniment for treating mouth and tooth diseases and applicator

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063]

[0064]

[0065] Preparation method: put carbomer in a stainless steel or acid and alkali resistant mixer, add an appropriate amount of water at 40~-50°C, stir well, after soaking for 36 hours, adjust the pH to 6 with sodium hydroxide, and take additional benzalkonium chloride, urine Add a small amount of purified water to vesicin, disodium edetate, polyvinylpyrrolidone and sodium saccharin, heat to dissolve, add to the carbomer glue, and stir well. Then take polyethylene glycol, Tween-60, zinc chloride, propyl gallate, propylene glycol, sorbic acid, and stearyl alcohol in a batching tank to dissolve at 70-75°C, add benzocaine to dissolve, and slowly Slowly add to the above glue, stir as you add, stir evenly, add peppermint oil, stir evenly, add pure water to the specified amount, stir well, and grind it finely through colloid milling.

Embodiment 2

[0067]

[0068] Preparation method: Take benzalkonium chloride, allantoin, disodium edetate and xylitol, add appropriate amount of pure water, heat to dissolve, and stir well. Then take polyethylene glycol, Tween-60, zinc chloride, ethyl hydroxybenzoate, propyl hydroxybenzoate, propylene glycol, and beeswax in a batching tank to dissolve at 70-75°C, add benzocaine to dissolve , slowly add to the above water liquid, stir as you add, stir well, add lemon oil, stir well, add pure water to the specified amount, stir well, let cool, that is.

[0069] The role of each excipient in the prescription

[0070] Synergist: This product uses allantoin (Allantoinunm), chemical name 2,5-dioxo-4-imidazolidinyl urea, as a synergist to assist in promoting ulcer and wound healing [10] .

[0071] Gel water-soluble matrix: Carbomer 934P type (Carbomer-934P), also known as polycarboxyethylene. Carbomer is a widely used new excipient. It is a compound obtained by copolymerization of high molec...

Embodiment 1

[0110]

[0111]

[0112] Preparation method: Take benzalkonium chloride, zinc chloride, citric acid, add appropriate amount of pure water, stir to dissolve, then add hydroxypropyl methylcellulose, stir for 30 minutes or more, until a uniform liquid is formed; take ethanol, propylene glycol, Put polyethylene glycol 400, ethyl hydroxybenzoate, and benzocaine in the batching tank, stir to dissolve, slowly add to the above glue, stir as you add, stir well, add peppermint oil, stir well, add pure Water to the specified amount, fully stirred, that is, the liquid medicine.

[0113] Example 2:

[0114]

[0115] Preparation method: Take ethanol, propylene glycol, polyethylene glycol 400, propolis, and menthol and put them in the batching tank, stir for 30 minutes or more, until a uniform liquid is formed, add benzocaine to dissolve, and set aside; take another Benzalkonium chloride Ammonium, zinc chloride, edetate disodium, polyvinylpyrrolidone add appropriate amount of pure ...

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PUM

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Abstract

The invention discloses compound benzocaine externally-applied medicinal liquid, gel or ointment. The medicine liquid, gel or ointment, which contains a compound medicine, is filled into an applicator to be applied on oral wound surfaces, ulcer surfaces and mucosa surfaces, treat tooth diseases, narcotize and relieve itching caused by haemorrhoids, treat itch and lubricate a nasopharyngeal catheter, inner root sight glass and the like for relieving pain.

Description

technical field [0001] The invention relates to a medicine for treating oral ulcer and tooth (gum) disease, in particular to an external medicine varnish and a smearing utensil mainly composed of benzocaine. Background technique [0002] Oral ulcer is a common symptom of oral mucosa, which can be caused by a variety of diseases. Among them, recurrent oral ulcer and herpetic ulcer are the two most common ulcers. Clinically, it is mainly manifested as four symptoms of "yellow, red, concave, and pain". The pain caused by the ulcer surface has a strong impact on the patient's work and life. In the past, many people used anti-inflammatory drugs for treatment, and there were also more oral analgesics, but their side effects on the gastrointestinal tract were obvious, and there were fewer types of local analgesics. [0003] Toothache is also a common disease and frequently-occurring disease of a kind of people, comprises gingival swelling and pain and pulpitis pain, and the latter...

Claims

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Application Information

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IPC IPC(8): A61K31/245A61K31/14A61K33/30A61K9/08A61K9/06A61P1/02A61P1/04A61P29/00A61M35/00A61M31/00A61C19/06
Inventor 徐朋刘布鸣
Owner 广西星银迪智药业有限公司
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