Yujin medicinal emulsion preparation

A technology of pharmaceutical preparations and fish gold emulsions, applied in drug combinations, pharmaceutical formulations, emulsion delivery, etc., can solve problems such as induction of allergic reactions, toxic reactions, nasal mucosa and cilia irritation

Inactive Publication Date: 2007-01-24
成都厚发科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the use of Tween substances in injection preparations, especially in traditional Chinese medicine injections, can cause toxic reactions in the human cardiovascular and cerebrovascular systems, and induce allergic reactions
According to the report of Chinese patent CN1615996A, Tween 80 has certain irritation and toxicity to nasal mucosa and cilia, and more obvious cilia toxicity may occur if it exceeds 2%

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018]Prescription composition: Houttuynia cordata 1.5kg, honeysuckle 1.5kg, refined soybean oil 150g, refined egg yolk lecithin 6g, refined glycerin 23g, add water for injection to 1000ml.

[0019] Combine Houttuynia cordata and honeysuckle, moisten it with distilled water, add distilled water 6-8 times, steam distill to obtain 3000ml of initial distillate, then carry out redistillation, collect 500ml of distillate, and set aside. Dissolve egg yolk lecithin in soybean oil and glycerin in the above distilled liquid, heat to 55°C respectively, mix well, disperse and emulsify in a tissue masher for 3-4 minutes, and then emulsify to The milk grains meet the requirements of the Pharmacopoeia (the milk grains below 1um should not be less than 90%, and the milk grains above 5um should not be detected), add water for injection to 1000ml, adjust the pH value to 6.0-8.0, cool, filter, and pack in infusion bottles. Sterilize to obtain emulsion type injection.

Embodiment 2

[0021] Prescription composition: Houttuynia cordata 4kg, honeysuckle 2kg, soybean oil for injection 150g, glyceryl caprylate 10g, soybean lecithin for injection 12g, glycerin for injection 25g, add water for injection to 1000ml.

[0022] Put Houttuynia cordata and honeysuckle into a conventional steam distiller, use a common oil-water separator as a distillate collection device, and fill the lower layer with an appropriate amount of water, and the upper layer with the above-mentioned soybean oil for injection. Houttuynia cordata and honeysuckle were extracted by steam distillation for 5 hours, and the oil phase layer in the above device was separated and collected to obtain soybean oil enriched with volatile oils of Houttuynia cordata and honeysuckle flower, and glyceryl caprylate was added to preheat the oil phase to 55°C, set aside. Add soybean lecithin to 500ml water for injection to disperse, then add glycerin, stir to dissolve, heat to 55°C, and continue to stir, at the s...

Embodiment 3

[0024] Prescription composition: Houttuynia cordata 15kg, honeysuckle 1.5kg, soybean oil for injection 80g, soybean lecithin for injection 15g, lipoic acid 1g, oleic acid 10g, xylitol for injection 50g, add water for injection to 1000ml.

[0025] Put Houttuynia cordata and honeysuckle into a conventional steam distiller, use a common oil-water separator as a distillate collection device, and fill the lower layer with an appropriate amount of water, and the upper layer with the above-mentioned soybean oil. Houttuynia cordata and honeysuckle were steam-distilled and extracted for 5 hours, and the oil phase layer in the above device was separated and collected to obtain soybean oil enriched with Houttuynia cordata and honeysuckle volatile oil, and lipoic acid and oleic acid were added for later use. Add soybean lecithin and xylitol for injection into an appropriate amount of water for injection, heat to 70°C, first stir with a tissue grinder at 8000-12000 rpm for 3 times to disper...

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PUM

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Abstract

The present invention is the recipe and preparation process of medicine Yujin preparation, and is especially emulsion type Yujin nose drops, which have the same antipyretic effect as the Yujin injection and may be used to replace Yujin injection clinically.

Description

technical field [0001] The invention relates to a formula and a preparation method of a fish gold emulsion pharmaceutical preparation, which can be made into injections, sprays, nasal drops, aerosols, spray inhalants and the like. Background technique [0002] Houttuynia cordata is the fresh whole herb or dry aerial part of Houttuynia cordata Thunb., which is one of the commonly used traditional Chinese medicines recorded in the Pharmacopoeia of the People's Republic of China in 2005. Evacuation of pus, the effect of inducing diuresis to relieve stranguria, can be used for the treatment of lung abscess and vomiting of pus, phlegm-heat wheezing and coughing, dysentery, pyretic stranguria, carbuncle sore tumefacting virus. Yan Shuangyin reported in "Strait Pharmacy" 2003; 15(1): 8, and Wu Wei in "Chinese Herbal Medicine" 2001; 32(4): 367 that Houttuynia cordata contains volatile oil, and the oil contains antibacterial ingredient houttuyniatin (caprylic acetaldehyde), methyl n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K9/107A61P11/00A61P13/00A61P15/00A61P17/02
Inventor 陈刚杨秀清周家明
Owner 成都厚发科技开发有限公司
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