68 results about "Nose Drops" patented technology

The purpose of the invention is to disclose a porcine circovirus, porcine parvovirus and porcine reproductive and respiratory syndrome virus triplex virus-like particle vaccine and its preparation method. The triple virus-like particle vaccine (Triple VLP vaccine) of the invention contains VLP which is composed of PCV-2 major structural protein CAP protein, PPV VP2 protein epitope and PRRSV Gp5 protein epitope. It is proved by experiment that the vaccine can stimulate good double cellular and humoral immune response. It is shown by pharmacodynamic test that after immunization of different animal groups, the vaccine of injection, nose drops and water forms prepared by VLP antigen formed by the method with or without adjuvants can safely and effectively prevent the infection of PCV-2, PPV and PRRSV. The invention provides an ideal vaccine for the security of sows, piglets and fattening pigs to effectively prevent mixed infection of PCV-2, PPV and PRRSV.

The present invention provides an apigenin vesiculation preparation and its preparation process. Said preparation composition includes (by wt%) 0.25%-20% of apigenin, 40%-90% of non-ionic surface active agent, 8.7-48.8% of cholesterol and 2%-20% of lyophilization protection agent. The described non-ionic surface active agent can be Span-20, Span-40, Span-60, Span-80, Tween-20, Tween-60, Tween-80, benzozir, maizir, poloxamer or their mixture. Said invention can be made into preparations of injection, nose drops, ointment and oral liquor, etc, and can be prepared by adopting ethyl alcohol injection method, film dispersion method, inversed phase evaporation method, hydration method, extrusion method, mechanical method and pH gradient method.

The invention discloses a porcine circovirus-like particle, a vaccine and a preparation method thereof. The virus-like particle is composed of a main structural protein-nucleocapsid protein of 2-type porcine circovirus, can excite cell and humoral immune response, can be used as a virus-like particle vaccine (VLP vaccine) to immune different fauna and can safely and effectively prevent PCV-2 infections after being used. The VLP can be made into injections, nose drops and drinking preparations by adding adjuvants or not. An ideal vaccine is provided for security of different populations of sows, piglets, fattening pigs and for effective immune prevention and control of PCV-2 infections.

The invention discloses a traditional Chinese medicine compound preparation for treating rhinitis and nasosinusitis and a preparation process thereof. The preparation is prepared from the following raw materials in parts by weight or in parts by volume: 100-200 parts by weight of honeysuckle, 60-120 parts by weight of cocklebur fruit, 60-120 parts by weight of radix scrophulariae, 40-80 parts by weight of liquorice and 1-2 parts by volume of dementholized peppermint oil. The raw materials are taken and conventional accessories are added to the raw materials; and then the mixture is prepared according to the conventional process into nasal delivery preparations including but not limited to nose drops, nasal spray and nasal gel. The compound traditional Chinese medicine nasal delivery preparation provided in the invention is prepared by thoroughly extracting the main active ingredients of the raw materials and has obvious curative effect for treating rhinitis (comprising acute rhinitis, chronic rhinitis and allergic rhinitis) and nasosinusitis.

An exterior-applied Chinese medicine in the form of nose drops for treating cold is prepared from 9 Chinese-medicinal materials including giant knotweed rhizome, ephedra, tree peony bark, xanthium fruit, etc through immersing them in alcohol solution, filter to obtain clean liquid, laying aside for at least 12 hr, taking supernatant, filtering, recovering alcohol, and mixing with distilled water.

The invention relates to a compound composition containing intal and statins claritin. The compound composition consists of the following components: a) a certain amount of intal; b) a certain amount of one of olopatadine hydrochloride, ioratadine, desloratadine, degreasing ioratadine, desloratadine, rupatadine and betahistine; c) other medicinal excipients. The compound composition can be made into external preparations such as eye drops, nose drops, aerosol, spray, inhalant, gelata, eye ointments, ointments or patch and the like. The compound composition can be used for curing the diseases such as anaphylactic eye diseases, anaphylactic rhinitis, skin urtication, urticaria, allergic asthma and the like, can significantly improve allergic symptoms, and has the characteristics of high efficiency, stability, safety, low adverse reaction rate, convenient use and the like.

The present invention is the recipe and preparation process of medicine Yujin preparation, and is especially emulsion type Yujin nose drops, which have the same antipyretic effect as the Yujin injection and may be used to replace Yujin injection clinically.

A water soluble of Penxiluowei contains the Penxiluowei or its salt, solubilizer, cosolvent and pH regulator. It can be used to prepare injection, eye drops and nose drops for treating the diseases caused by herpes simple virus, herpes zoster virus and hepatitis B virus.

The present invention relates to a plant component aromatic preparation for relieving emotional tonicity, anxiety and depression and its preparation method. It is made up by using volatile oil extracted from Chinese medicinal material bighead atractylodes rhizome, aromatic volatile oil extracted from one of Chinese medicinal materials of peppermint, atractylodes rhizome, cablin pacholi and folium eucalypti or more than one of them and any one of auxiliary materials of ethyl alohol, Tween-80, methylparaben, ethylparaben, propanediol, vitamin E, vitamin C, cysteine, citric acid and sodium sulfite or several kinds of them through a certain preparation process. Said invention can be made into spray, aerosol, nose drops, nose pigment, cream, ointment, liniment and oil solutions.

A Chinese medicine in the form of nose drops for treating cold is prepared from 6 Chinese-medicinal materials including ephedra, trichosanthes root, magnolia flower, houttuynia, etc through immersing in alcohol solution, filtering to obtain clean liquid, laying aside, taking supernatant, filtering, recovering alcohol, and mixing with distilled water.

The invention relates to black cumin seed oil nose drop and a preparation method thereof. The black cumin seed oil nose drop is prepared from black cumin seed oil or from black cumin seed oil, scabrous mosla herb, herba ephedra, radix angelicae, violet magnolia, centipeda minima, schizonepeta and radices sileris in a compounding manner. The black cumin seed oil nose drop disclosed by the invention is used for directly acting on the mucosa of the nasal cavity, becomes effective rapidly, and can relieve inflammatory cell infiltration of the nasal mucosa caused by rhinitis and nasosinusitis and inhibit hyperplasia of connective tissues below the mucosa so as to improve nasal obstruction caused by swelling of the nasal mucosa, so the black cumin seed oil nose drop is suitable for treating various rhinitis and has a better effect than clinical commonly-used biyanling pills, centipeda minima nasal drops and the like.

The present invention discloses a Chinese medicine for curing allergic rhinitis. It is made up by using (by wt%) 10-50% of centipede, 10-50% of ligusticum root, 5-20% of asarum, 5-20% of magnolia flower and 5-20% of scutellaria root through a certain preparation process. Said invention also provides its preparation process and concrete steps. Said medicine can be made into nose drops and nose spray preparation.

The invention relates to nose drops taking fibrauretine as a main medicine and a preparation method thereof. The nose drops comprise the following components of raw materials by weight ratio: 0.1-2% of fibrauretine and the balance auxiliary materials. The preparation method comprises the following steps: dissolving the auxiliary materials by adopting a slushing method used for hydroxypropyl methylcellulose, enabling the auxiliary materials to form a uniform insoluble paste, then adding room-temperature water with the equivalent quantity and stirring until dissolving completely; adding physiological saline into fibrauretine powder, heating, dissolving and leaching to obtain supernatant liquid; and stirring and mixing a hydroxypropyl methylcellulose solution and the supernatant liquid of the fibrauretine evenly, then adding the physiological saline, fixing the volume to the required quantity, stirring evenly, regulating the pH value to 5.5-6.5, filtering and subpackaging. By the experimental verification, the nose drops do not have an irritative inflammatory reaction, have a better suppression function to inflammation and have better stability.

The invention discloses application of montmorillonite in preparing a medicament, in particular application of the montmorillonite in preparing a medicament for preventing and treating cold. The cold comprises common cold and influenza. A prepared pharmaceutical dosage form of the montmorillonite for preventing and treating the cold is a montmorillonite nose drop; a prepared pharmaceutical dosage form of the montmorillonite for preventing and treating the cold is a montmorillonite spray; and a prepared pharmaceutical dosage form of the montmorillonite for preventing and treating the cold is a montmorillonite aerosol. The invention has the advantages that the invention explores the novel use on pharmaceutical montmorillonite and develops a novel application field; the montmorillonite nose drop or the montmorillonite spray or the montmorillonite aerosol can prevent and treat the common cold and the influenza; the montmorillonite only acts on the upper respiratory tract, is not absorbed by an organism, and has no toxicity and side effect; viruses and bacteria do not produce the drug tolerance; and the advantages of easily-obtained raw materials, low cost and low treatment cost are obviously superior to medicaments which are commonly used for preventing and treating the influenza at present.

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition, a nose drop containing the same and application thereof. The traditional Chinese medicine nose drop is made of, by weight, 2-4 parts of agarwood, 1-5 parts of xanthium sibiricum and 1-4 parts of mint. The traditional Chinese medicine nose drop not only has effects of antisepsis and anti-inflammation and nasal mucosa protection, but also has effects of calming the nerves and relieving fatigue, and has fewer side effects.

The invention provides a novel epinastine nasal drug delivery preparation and a preparation method thereof. According to the requirements of nose drops and biological characteristics of epinastine, an appropriate protective agent, a thickener and a corrosion remover are added to prepare aqueous solution nose drops. The novel epinastine nasal drug delivery preparation is free of bitter taste and thrill, and is suitable for nasal delivery, convenient to use, and especially suitable for medication on children and the old. The technological process provided by the invention has the advantages of being simple and reliable, and good in repeatability, can be applied to prevention and treatment of anaphylactic (including seasonal or non-seasonal) rhinitis, and has certain application value in clinical.

The medicine preparation for treating gastrointestinal tract reaction caused by chemotherapy contains the main components Troposetron, Troposetron methanesulfonate or Troposetron hydrochloride. It is prepared into nasal cavity administrated preparation, including nose drop, nose spray or nasal powder. The present invention is convenient in use and has small dosage and lessnegative reaction.

A recombinant human interferon alpha nose-drops for preventing and treating influenza, upper respiratory tract infection and fever is prepared from recombinant human interferon, protecting agent, thickening agent and antiseptic.

The invention discloses a nose drop for treating allergic rhinitis and a preparation method thereof. The nose drop is prepared from the following raw materials in parts by weight: 1-5 parts of magnolia flower volatile oil, 2-5 parts of herba menthae volatile oil, 100-150 parts of sesame oil and 0.05-0.12 part of nipagin. The preparation method of the nose drop comprises the following steps: respectively taking a proper amount of flos magnoliae and herba menthae, adding water, performing heating, and respectively collecting the flos magnoliae volatile oil and the herba menthae volatile oil by using a volatile oil extractor; proportionally taking the sesame oil, then adding the obtained flos magnoliae volatile oil, the obtained herba menthae volatile oil and nipagin into the sesame oil, andperforming uniform stirring; and sub-packaging 5ml of the obtained substance in each bottle. The nose drop for treating allergic rhinitis is prepared from the volatile oil extracted from traditional Chinese medicine flos magnoliae and herba menthae; and the nose drop is small in volume, simple in preparation process, suitable for industrial mass production, fast in taking effect, convenient to use, high in safety and free from toxic and side effects, and provides more medication options for patients and especially out-of-hospital patients who suffer from allergic rhinitis and cannot orally take medicines.

The invention belongs to the technical field of medicines, and discloses application of cucurbitacin in the preparation of medicaments for treating cough. The cucurbitacin comprises cucurbitacin A, B, C, D, E, I, Q and S, dihydrocucurbitacin A, B, C, D, E, I, Q and S, isocucurbitacin A, B, C, D, E, I, Q and S, and one or more than two of glucoside substances corresponding to each cucurbitacin. The cucurbitacin can be prepared into tablets, capsules, granules, powder, suspensions, syrups, oral liquid, patch, ointment, aerosol, suppository, nose drops or injection and the like with a pharmaceutically-acceptable carrier, can be used for treating the cough caused by various reasons, and has the effect of eliminating phlegm. The dose of healthy adults is between 0.1 and 5 mg / d, and preferable is between 0.3 and 3 mg / d; and the dose of children is subjected to discretionary reduction.

The invention provides a broad-spectrum anti-variant new coronavirus IgY, a composite antibody, a preparation method and a combined preparation. The invention provides a method for preparing a broad-spectrum anti-mutated new coronavirus IgY antibody, an anti-mutated new coronavirus IgY antibody and a combined antibody. The IgY, the composite IgY and the combined antibody can be combined with antigenic epitopes with strong conservative property to achieve a broad-spectrum neutralization effect, and the problem that the new coronavirus is easy to mutate and immune escape is solved. The invention also develops a series of preparations containing the broad-spectrum anti-variant new coronavirus composite IgY. The invention also provides a central air-conditioning atomization disinfectant and an external package spray disinfectant prepared from the IgY and the composite IgY, and an atomization inhalation atomization agent, a spray, a mouth spray, a nasal spray, a nose drop, an eye drop, an air disinfectant, a hand sanitizer, powder, tablets, buccal tablets, oral liquid and capsules. The compound is applied to medicines, disinfection products, health care products and medical instruments for preventing and treating new coronavirus infection.

The invention discloses a traditional Chinese medicine preparation for curing migraine, which is prepared by extracting 1 proportion of rhizoma ligustici wallichi, 0.45-1.2 proportions of cinnamomum migao H.W.Li, 0.40-1.1 proportions of raphani, 0.005-0.15 proportion of artificial musk, 0.002-0.03 proportion of borneol and additives, in addition, nasal cavity spraying agents and nose drops can also be prepared. According to the traditional Chinese theory of 'the brain is linked with the nose', the medicine is taken through the nasal cavity, which has rapid pain relieving effect, high potency and no toxicity and side effects.

The invention relates to Chinese medicinal nose drops for treating colds and a quality control method and application thereof. In the Chinese medicinal nose drops, radix bupleuri, houttuynia cordata thumb and liquoric root are taken as raw materials, the mass ratio of the composition raw materials of radix bupleuri to houttuynia cordata thumb to liquoric root is 50 to 35 to 15; effective positions are respectively extracted by adopting modern methods such as steam distillation, ethanol extraction, decoction by water and the like according to different properties of pharmacodynamic components of each Chinese medicament, and the nose drops are prepared by mixing the effective positions and auxiliary materials accepted by the nose drops. Simultaneously, the invention also relates to the quality control method and application of the Chinese medicinal nose drops, and discloses a qualitative identification method and a quantitative determination method of the nose drops. The Chinese medicinal nose drops have a unique formula and scientific preparation method, retain the natural characteristic of the active ingredients of the medicaments, and have the obvious effect on the treatment of colds through the administration of nasal cavities.

The invention discloses a medicament for treating disorder of spleen and stomach and abdominal swelling and pain. Rhizoma pinellinae praeparata, dried ginger, coptis root, Chinese thorowax root, rose, white paeony root, Chinese angelica, prepared rehmannia rhizome, dwarf lilyturf root, bitter orange, fingered citron, chicken gizzard membrane, coked areca nut, coked fructus crataegi, fried malt, fried rice sprout, south dodder seed, mulberry and officinal magnolia bark are taken as raw materials, and various conventional auxiliary materials such as a thickening agent, an adhesive, a sweetening agent and the like needed for preparing different dosage forms are added, so that any common oral preparation such as pills, capsules, particles, an oral liquid and the like are prepared with the conventional Chinese medicine preparation method. Compared with various commercially-available medicaments such as nose drops and the like, the medicament has the effects of low cost, easiness for processing, remarkable curative effect, safety for using, high curative rate, no relapse, no bounce and the like, and is easily accepted by patients.

The invention discloses a nose drop for relieving nasal polyp symptom. The nose drop is mainly prepared from, by mass, 8-15 parts of rhizoma alismatis, 4-8 parts of radices trichosanthis powder, 3-7 parts of clerodendrum bungei, 5-12 parts of cordate houttuynia, 8-14 parts of lotus leaf bases, 5-10 parts of adenophora trachelioides maxim., 4-9 parts of wild centella aslatlca urban, 10-15 parts of membranes of hen eggs, 6-11 parts of folia perillae acutae, 4-8 parts of arabian jasmine flowers, 7-12 parts of tabasheer, 3-7 parts of sensitive joint vetch wood, 2-6 parts of radix bupleuri and 4-9 parts of asiatic striga. The nose drop is scientific in formula and synergic in effect, has the effects of clearing away heat and toxic materials, nourishing yin to moisten dryness and the like and is good in curative effect and capable of effectively preventing recurrence.

A Chinese medicine in the form of nose drops for treating cold is prepared from 9 Chinese-medicinal materials including giant knotweed rhizome, trichosanthes root, ephedra, tree peony bark, etc through immersing in alcohol solution, filtering to obtain clean liquid, laying aside, taking supernatant, filtering, recovering alcohol and mixing with distilled water.

The invention discloses neural stem cell nose drops as well as a preparation method and application thereof. The neural stem cell nose drops comprise neural stem cell exosome freeze-dried powder, a surfactant, a stabilizer and an osmotic pressure regulator; the surfactant is lecithin; the stabilizer is oleic acid; and the osmotic pressure regulator is glycerol. According to the neural stem cell nose drops as well as the preparation method and application thereof, endogenous neural stem cells of an organism are mobilized to treat cranial nerve injuries, including Alzheimer's disease, Parkinson's disease and depression.

The invented naristillae is composed of naphazoline hydrochloride nose drop 3-8 ml. contianing 0.1% naphazoline hydrochloride, lincomycin hydrochloride solution 2-6 ml. containing 0.6-1.8 gm licomycin hydrochloride, prednisolone aectate solution 1-5 ml. containing prednisolone acetate 25-125 mg. Advantages include: apparent therapeutic effect quick action, easy to use it, no recurrence etc.

The invention discloses a composition for treating atrophic rhinitis and a preparation method thereof and belongs to the technical field of traditional Chinese medicines. In the invention, according to the principle of nourishing lung and moistening dryness and activating blood and resolving stasis in traditional Chinese medicine, a simple formula is employed with a great effect for treating the atrophic rhinitis. In the composition for treating the atrophic rhinitis, three sour and sweet traditional Chinese medicines, including fructus mume, dried radix rehmanniae and scrophularia ningpoensis, are combined for nourishing yin, so that effects of nourishing yin, moistening dryness, engendering fluid, promoting hyperplasia of mucosa glands, activating bloods and resolving stasis, and promoting local blood supplement. Vitamin E can form a panniculus adiposus locally for alleviating dryness in nasal passages, improving micro-circulation in blood, providing nutrition for mucous membranes in the nasal passages and promoting the mucous membranes in the nasal passages to recover. The composition for the treating atrophic rhinitis is prepared into a nano nose-drop emulsion since an emulsifying agent is added. The composition, with tradition Chinese medicine and western medicines combined therein, is simple in components, is small in dosage, is free of toxic and side effects and is suitable for long-period usage. When being prepared into the nano nose-drop emulsion through ultrasonic extraction, the composition is stronger in effects and is longer in lasting time, and is helpful to recovery of the atrophic rhinitis and can significantly alleviating the symptoms.

The invention discloses a nose drop for quickly treating epistaxis. Each 100ml of nose drop comprises the following main components: 10-15g of folium callicarpae pedunculalae water extract, 3-6g of dandelion water extract, 2-6g of radix isatidis water extract and 4-8g of radix sophorae tonkinensis water extract. The nose drop has the efficacies of clearing away heat and toxic materials, cooling blood and stopping bleeding, invigorating the circulation of blood and reducing blood, discharging fire and eliminating dampness, calming liver wind and regulating yin and yang, vital energy and blood, high-concentration antibiotic medicine attack can be carried out on stubborn germs from a mucosa layer and vibrissa of a nasal cavity, and the nose drop is quick and thorough in epistaxis treatment, significant in curative effect, safe to take, significant in treatment effect, quick in hemostasis and worthy of popularization and application.