Application of cucurbitacin in preparation of medicaments for treating cough

A technology of cucurbitacin and medicine, applied in the field of medicine, can solve the problem of drug dependence in patients, and achieve the effects of improving lung function, reducing cough symptoms, and clearing phlegm.

Active Publication Date: 2011-05-04
SHENYANG PHARMA UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many cough medicines on the market. While relieving cough symptoms, their unique ingredients make patients addicted to drugs. Cucurbitacin is a traditional Chinese medicine extract, which has the characteristics of safety, low toxicity, and rogue drug properties. For the treatment of cough, it can be seen that it has a better application prospect than western medicine in this respect

Method used

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  • Application of cucurbitacin in preparation of medicaments for treating cough
  • Application of cucurbitacin in preparation of medicaments for treating cough
  • Application of cucurbitacin in preparation of medicaments for treating cough

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 cough-relieving effect research

[0025] Mice with a body weight of 18-22 grams, half male and half female, were randomly divided into groups of 10 mice, and the dosage of each group was shown in Table 1. Each mouse was intragastrically administered once a day at 0.2ml / 10g body weight for 5 consecutive days. One hour after the last administration, the mice were put into the bell jar one by one, sprayed into the aerosol of ammonia water evenly for 30 seconds, moved the mice out of the bell jar, and observed immediately. The cough latency of the mice and the number of times of coughing within 3 minutes were recorded (when coughing, the mouth of the mice was wide open and the abdominal muscles contracted strongly). The results are shown in Table 1.

[0026] Table 1. Results of the Antitussive Effect Study

[0027]

[0028]

[0029] As can be seen from the results in Table 1, different cucurbitacin monomers can exert antitussive effect by intragastric ...

Embodiment 2

[0031] Embodiment 2 expectorant effect research

[0032] 120 mice weighing 18-22 grams were taken, divided into 12 groups, and tested according to the phenol red method. The route of administration was intraperitoneal injection, and the same volume of normal saline was used in the control group. After 45 minutes, each mouse was intraperitoneally injected with 0.25 ml of 5% phenol red saline solution. 30 minutes after the injection, kill the animal, separate the trachea, insert a No. 6 needle into the trachea about 0.5 mm, fix it, draw 0.5 ml of 5% sodium bicarbonate solution with the syringe, and repeatedly rinse 6 times through the needle, collect sodium bicarbonate for washing solution in a 5ml volumetric flask, constant volume 5ml, mixed, filtered, 546nm colorimetric determination of phenol red content, the results are shown in Table 2.

[0033] Table 2 Results of expectorant effect study

[0034]

[0035]

[0036] It can be seen from the data in Table 2 that, compar...

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PUM

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Abstract

The invention belongs to the technical field of medicines, and discloses application of cucurbitacin in the preparation of medicaments for treating cough. The cucurbitacin comprises cucurbitacin A, B, C, D, E, I, Q and S, dihydrocucurbitacin A, B, C, D, E, I, Q and S, isocucurbitacin A, B, C, D, E, I, Q and S, and one or more than two of glucoside substances corresponding to each cucurbitacin. The cucurbitacin can be prepared into tablets, capsules, granules, powder, suspensions, syrups, oral liquid, patch, ointment, aerosol, suppository, nose drops or injection and the like with a pharmaceutically-acceptable carrier, can be used for treating the cough caused by various reasons, and has the effect of eliminating phlegm. The dose of healthy adults is between 0.1 and 5 mg/d, and preferable is between 0.3 and 3 mg/d; and the dose of children is subjected to discretionary reduction.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a new medical application of a known substance, cucurbitacin, in the preparation of medicine for treating cough. Background technique [0002] Cucurbitacins belong to a class of tetracyclic triterpenoids with a 19-methyl group appearing at the C-9 position. They are mainly distributed in Cucurbitaceae plants. It is also found in higher plants such as wood family and some large fungi. Qiu Minghua, a researcher at the Kunming Institute of Botany, Chinese Academy of Sciences, led scientific and technical personnel to study 229 almost all cucurbitacin compounds on the basis of the discovery of a series of new types of cucurbitacin compounds, and proposed a new structural classification model, which was reconstructed from the previous five structural types. Divided into 12 categories, it has been recognized by the international academic community. At present, the cucurbitacin appro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61K31/704A61K31/58A61P11/14A61P11/10A61P11/00
Inventor 邓意辉
Owner SHENYANG PHARMA UNIVERSITY
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