The invention relates to a unibract fritillary bulb and loquat leaf medicinal composition and a preparation method thereof. Four Chinese herbal medicines, namely unibract fritillary bulb, platycodon grandiflorum, loquat leaf, and menthol crystal are selected and the preparation method comprises the following steps of: crushing unibract fritillary bulb into fine powder for later use, crushing platycodon grandiflorum powder into fine powder, taking a certain amount of platycodon grandiflorum fine power for later use, mixing residual platycodon grandiflorum powder and loquat leaf, adding water and decocting, filtering for different times, mixing filtrates, standing, taking supernate, concentrating to obtain plaster, adding platycodon grandiflorum fine power, uniformly mixing, drying, grinding, adding unibract fritillary bulb fine powder, mixing uniformly, pelletizing, drying, adding menthol crystal and auxiliary materials, mixing uniformly, and preparing various formulations according to clinical requirements. The medicine is prepared from non-toxic and pure Chinese herbal medicines, the medicine prepared by the process can be absorbed easily, the utilization rate of active ingredients of the medicine is higher, and the medicine is convenient to take and carry, and is low in preparation cost. If 70 percent ethanol is added into one third unibract fritillary bulb fine power for extraction and then the subsequent operation is performed, the prepared medicine has better curative effects.