Anti-cold drug suitable for children aged 4-11 years old and preparation method of drug

A technology for children to take and take medicine, applied in the directions of pharmaceutical formula, drug combination, drug delivery, etc., can solve the problem of not giving, and achieve the effects of increasing stability, relieving nasal congestion, and improving compliance.

Inactive Publication Date: 2019-10-08
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this invention, vitamin C is used as an antioxidant (in embodiment 1), but vitamin C has clear pharmacological activity, whether it will affect the chemical activity and pharmacological effects of dextromethorphan hydrobromide and phenylephrine hydrochloride, the patent no corresponding expression or explanation given

Method used

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  • Anti-cold drug suitable for children aged 4-11 years old and preparation method of drug
  • Anti-cold drug suitable for children aged 4-11 years old and preparation method of drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1 (preparation 1000ml is example)

[0041] 1. Active ingredient: dextromethorphan hydrobromide 1g phenylephrine hydrochloride 0.5g,

[0042] 2. Other auxiliary ingredients: 600.00g sucrose, appropriate amount of sodium hydrogen phosphate, 0.05 tert-butyl hydroquinone, 85g propylene glycol, 0.5g sodium sorbate, 300.0g xanthan gum, 0.5g allura red, 0.5g apple essence, plus Purified water to 1000ml.

[0043] 3 preparation method:

[0044] 3.1. Take about 200ml of purified water and put it into a 1000ml beaker, add the above prescription amount of propylene glycol, heat it in a water bath at 60°C, then add the prescription amount of dextromethorphan hydrobromide and phenylephrine hydrochloride in turn, shake, Make it dissolve, obtain material a;

[0045] 3.2. Weigh the prescription amount of xanthan gum, sucrose, tert-butylhydroquinone, and sodium sorbate into a 500mL beaker, add 300ml of solvent, heat to about 50-70°C, stir until the solution is clear and tra...

Embodiment 2

[0048] Embodiment 2 (preparation of 1000ml is an example):

[0049]1. Active ingredient: dextromethorphan hydrobromide 1g phenylephrine hydrochloride 0.5g,

[0050] 2. Other auxiliary ingredients: stevia 0.1g, appropriate amount of anhydrous citric acid, propyl gallate 0.1g, glycerin 92.0g, sodium benzoate 1.0g, sucrose 0.1-1.0g, carbomer 380.0g, bright green pigment 0.1 g. Orange essence 0.1-1.0g, add solvent to 1000ml.

[0051] 3. Preparation method:

[0052] 3.1. Take about 200-300ml of the solvent and put it into a 1000ml beaker, add the above prescription amount of glycerin, heat it in a water bath at 60°C, then add the prescribed amount of dextromethorphan hydrobromide and phenylephrine hydrochloride in turn, and shake , make it dissolve to obtain material a;

[0053] 3.2. Weigh the prescription amount of sucrose, stevioside, propyl gallate, and sodium benzoate into a 500mL beaker, add 300-400ml of solvent, heat to about 50-70°C, stir until the solution is clear and t...

Embodiment 3

[0056] Embodiment 3 (preparation 1000ml is example): (preferred)

[0057] 1. Active ingredient: dextromethorphan hydrobromide 1g phenylephrine hydrochloride 0.5g,

[0058] 2. Other auxiliary ingredients: acesulfame potassium 1.0g, citric acid, sodium citrate about 2-40g, edetate disodium 0.1g, propylene glycol 92.0g, sodium benzoate 1.0g, maltitol 380g, allura red 0.5g 1. Cherry essence 0.5g, add solvent to 1000ml.

[0059] 1. Take about 200-300ml of solvent and put it into a 1000ml beaker, add the above prescription amount of disodium edetate, heat it in a water bath at 60°C, then add the prescription amount of dextromethorphan hydrobromide and hydrochloric acid to Oxyepinephrine was shaken to make it dissolve to obtain material a;

[0060] 2. Weigh the prescribed amount of maltitol, acesulfame potassium, and sodium benzoate into a 500mL beaker, add 300-400ml of solvent, heat to about 50-70°C, stir until the solution is clear and transparent, and obtain material b;

[0061...

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Abstract

The invention relates to an anti-cold drug suitable for children aged 4-11 years old and a preparation method of the drug. Dextromethorphan hydrobromide and phenylephrine hydrochloride are taken as active ingredients, a pH regulator is added to regulate the pH value to 3.8 +/- 2, and auxiliary ingredients such as a cosolvent, a stabilize, a thickening agent, a bacteriostat and the like are added,so that the defects in the prior art are effectively solved, and the stability of the drug is increased. At the same time, a certain amount of flavoring agent and aromatic agent are added to improve the compliance of children. The drug is mainly used for relieving nasal obstruction and cough caused by common cold of children aged 4-11 years old.

Description

technical field [0001] The invention belongs to the field of medicine research and development preparations, and in particular relates to an anti-cold medicine suitable for children aged 4-11 and a preparation method thereof. [0002] technical background [0003] Colds in children are mostly caused by viral infections. In terms of medication, there are very few cold medicines for children. In our country, due to improper medication or excessive dosage, countless damages to liver, kidney function, nervous system, etc. have been caused. [0004] Dextromethorphan hydrobromide is the dextro-isomer of morphine levomorphan methyl ether, which exerts central antitussive effect by inhibiting the medullary cough center. Its antitussive effect is strong, and there is no tolerance and addiction in long-term application. However, overdose can cause dizziness, mild drowsiness, dry mouth, constipation and other symptoms. [0005] Phenylephrine hydrochloride is an α1-ADR agonist with dil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/485A61K31/137A61P11/00A61P11/02A61P11/14
CPCA61K9/0095A61K31/137A61K31/485A61K47/183A61K47/26A61P11/00A61P11/02A61P11/14A61K2300/00
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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