11 results about "Tetracyclic triterpenoids" patented technology

The invention discloses a compound with anti-tumor activity. The compound has a chemical structural formula as shown in a formula (I). The compound belongs to a novel tetracyclic triterpenoid natural product, has good fat solubility and chemical stability, and can be conveniently extracted from the rhizome of a herbal medicine Polygala fallax Hemsl. And prepared into an oral or injection form. The invention also provides a preparation method and application of the compound. The compound provided by the invention can obviously inhibit the growth of mouse lung cancer and reduce the volume and weight of tumor, and can be used for treating tumor diseases.

The application discloses a compound with the function of purgation and water excretion, which has a chemical structural formula as shown in formula (I). The compound is a new natural product of tetracyclic triterpenes, has good fat solubility and chemical stability, can be conveniently extracted from the rhizome of the herbal medicine Alisma orientale and prepared into an oral or injection dosage form. The application further provides a preparation method and application of the compound. The compound can obviously inhibit the increase of the abdominal volume and the weight of ascites of mice in a dose-dependent manner, and is a new water excretion drug with great potential.

The invention discloses a beta-elemonic acid derivative and a preparation method and application thereof, and belongs to the technical field of biological medicine, the structural formula of the beta-elemonic acid derivative is shown in the specification, the R1 group is one of 4-H, 4-Cl, 4-OCH3 and 3, 4, 5-(OCH3) 3; and R2 is one of 4-H, 4-F, 4-Cl and 4-OCH3. Tetracyclic triterpenoid beta-elemonic acid is used as a lead compound, a 1, 2, 3-triazole structure with anticancer activity is introduced, and the generated beta-elemonic acid derivative has low toxicity to human normal hepatocytes, high selectivity to tumor cells and remarkable anti-proliferation effect.

A novel multi-fused-ring compound and a composition for preventing or treating multiple myeloma comprising the same as an active ingredient is described herein. The compound is a derivative synthesized from the natural compound ginsenoside as a starting material, and shows no cytotoxicity to normal hematopoietic stem cells, while exhibiting a significant killing effect on various multiple myeloma cell lines, indicating that it may be administered for a long period of time without side effects. In addition, the compound exhibits a significant synergistic effect when co-administered with the immunomodulator thalidomide or its analog lenalidomide, and thus may be useful as an efficient therapeutic agent or therapeutic aid agent composition for multiple myeloma, an incurable disease.

The present invention discloses a dammarane-type tetracyclic triterpenoid saponin composition and its application, belonging to the field of biomedicine technology. The present invention combines three saponins (notoginsenoside Ft1, 20(R)-ginsenoside Rh2, and 20(R)-ginsenoside Rg3) to prepare a composition. The composition effectively inhibits the elevation of triglycerides (TG), total cholesterol (TC), malondialdehyde (MDA), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the liver of mice in both high-dose (40 mg / kg) and medium-dose (20 mg / kg) groups. It also effectively promotes the synthesis of glutathione (GSH), curbing the weight loss and liver weight gain of mice. The high-dose composition effectively curbs the formation of fat particles in the liver and has a good therapeutic effect on alcoholic fatty liver disease.

The invention discloses a tetracyclic triterpenoid compound as well as a preparation method and application thereof, and belongs to the technical field of active ingredient analysis of marine fungi. The tetracyclic triterpenoid compound with a novel structure is extracted and separated from a secondary metabolite generated by fermentation culture of a marine fungus Fusarium sp.MA-414 in a potato liquid culture medium, the structural formula of the tetracyclic triterpenoid compound is shown as a formula (I), and the structure of the compound is different from the previously reported spatial configuration. Antibacterial and lipid-lowering tests show that the tetracyclic triterpene compound provided by the invention has better antibacterial and lipid-lowering activity, can be used for preparing antibacterial and lipid-lowering medicines, and has a good development prospect.

The invention discloses a tetracyclic triterpenoid compound with anti-tumor activity as well as a preparation method and application thereof. The compound is separated from a traditional Chinese medicine euphorbia pekinensis, the molecular formula is C29H44O4, the absolute configuration of the compound is identified as 3R, 5S, 10R, 11R, 13S, 14R, 17S and 20R, and the compound is a tetracyclic triterpenoid compound with a new structure. The preparation method comprises the following steps: carrying out reflux extraction on dried euphorbia pekinensis roots with ethanol, concentrating, suspending with water, extracting with dichloromethane, and separating and purifying the obtained extract through silica gel column chromatography, Sephadex LH-20 column chromatography and preparative high performance liquid chromatography in sequence. In-vitro anti-tumor experiments show that the compound has inhibitory activity on various liver cancer cell lines, and especially has a remarkable effect on HuH-7 cells. The compound can be used for preparing antitumor drugs, and the preparation method is reasonable in process, low in cost and suitable for large-scale production.

Disclosed in the present invention is a compound having an anti-tumor activity, which has a chemical structural formula as shown in formula (I). The compound is a new natural product of tetracyclic triterpenoids, has a good lipid solubility and chemical stability, and can be conveniently extracted from the roots and stems of the herb Begonia limprichtii Irmscher and prepared into an oral or injectable dosage form. Further provided in the present invention are a method for preparing the compound and the use thereof. The compound of the present invention can significantly inhibit the growth of lung cancer in mice, can reduce the volume and weight of tumors, and can be used for treating tumor diseases.

The invention discloses a compound with an effect of drastically draining water. The compound has a chemical structural formula as shown in a formula (I). The compound belongs to a novel tetracyclic triterpenoid natural product, has good fat solubility and chemical stability, and can be conveniently extracted from the rhizome of a herbal medicine Polygala fallax Hemsl. And prepared into an oral or injection form. The invention also provides a preparation method and application of the compound. The compound provided by the invention can obviously inhibit the increase of abdominal volume and ascites weight of mice, is in a dose-dependent relationship, and is a novel drainage medicine with great potential.

The invention discloses a dammarane type tetracyclic triterpenoid saponin composition and application thereof, and belongs to the technical field of biological medicine. According to the invention, three saponins (notoginsenoside Ft1, 20 (R)-ginsenoside Rh2 and 20 (R)-ginsenoside Rg3) are combined to prepare the composition, and the composition can effectively inhibit the increase of triglyceride (TG), total cholesterol (TC), malondialdehyde (MDA), aspartate transaminase (AST) and alanine transaminase (ALT) of mouse livers in a high-dose (40mg / kg) group and a medium-dose (20mg / kg) group; the synthesis of glutathione (GSH) is effectively promoted, and the reduction of mouse body weight and the weight gain of liver are restrained; the high-dose composition effectively inhibits the generation of liver fat particles; the traditional Chinese medicine composition has a good treatment effect on alcoholic fatty liver.

The invention relates to the field of research on chemical effective components of traditional Chinese medicines, and relates to a tetracyclic triterpenoid compound which is separated and identified from an araliaceae ginseng plant Panax quinquefolius L.. According to the present invention, the compounds 1-4 are new compounds, the in vitro cell experiment results show that the compounds provide significant neuroprotection effects for human neuroblastoma cells SH-SY5Y induced by an in vitro Parkinson's disease model MPP +, the preparation method of the compounds is simple, the activity is excellent, and the new material basis is provided for the prevention and treatment of Parkinson's disease (PD).