Composition for treating atrophic rhinitis and preparation method thereof

A technology for atrophic rhinitis and composition, which is applied in the direction of drug combination, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of easily polluting the face and clothing, etc., and achieve the relief of dry nasal symptoms, Promoting recovery, easy to accept effect

Inactive Publication Date: 2015-02-04
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing traditional Chinese medicine treatment method is still mainly oral administration. Topical nasal administration is often used as an adjuvant therapy for oral administra

Method used

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  • Composition for treating atrophic rhinitis and preparation method thereof
  • Composition for treating atrophic rhinitis and preparation method thereof
  • Composition for treating atrophic rhinitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The nasal drop emulsion in this example is mainly composed of the following raw materials in parts by weight: 30 parts of rehmannia, 30 parts of Scrophulariaceae, 10 parts of dark plum, and 0.2 part of vitamin E.

[0025] The preparation method is:

[0026] Weigh 30 parts of raw ground, 30 parts of scrophulariaceae, and 10 parts of black plum, mix them, crush them with a steel mill to particles with a diameter of less than 2mm, add 5 to 10 times the volume of water, and perform ultrasonic extraction with an extraction power of 250 to 800W. The extraction temperature is 60-80°C, the extraction time is 60-90min, and the extraction is 2-3 times in total. After extraction, it is filtered through an 800-mesh filter, and the filtrate is concentrated to a relative density of 1.15-1.23. A mixed solution of rehmannia root, scrophulariaceae, black plum and vitamin E, and then add an emulsifier Loxamer 188 with a total mass of 1.5% of the mixed solution, adjust the pH value to 6.0...

Embodiment 2

[0036] The nasal drop emulsion in this embodiment is mainly composed of the following raw materials in parts by weight: 40 parts of rehmannia, 20 parts of Scrophulariaceae, 15 parts of black plum, and 0.15 parts of vitamin E.

[0037] Weigh 40 parts of raw land, 20 parts of scrophulariaceae, and 15 parts of black plum, mix them, crush them with a steel mill to particles with a diameter of less than 2 mm, add 5 to 10 times the volume of water, and perform ultrasonic extraction. The extraction power is 250-800W, the extraction temperature is 60-80°C, the extraction time is 60-90min, and a total of 2-3 extractions are performed. After extraction, filter through a 800-mesh filter, concentrate the filtrate to a relative density of 1.15 to 1.23, add 0.15 grams of vitamin E to make a mixed solution containing rehmannia root, Scrophulariaceae, black plum and vitamin E, and then add 1% of the total mass of the mixed solution Emulsifier Loxamer 188, adjust the pH value to 6.0-7.0, prepa...

Embodiment 3

[0047] The nasal drop emulsion in this embodiment is mainly composed of the following raw materials in parts by weight: 20 parts of rehmannia root, 15 parts of Scrophulariaceae, 10 parts of ebony plum, and 0.2 part of vitamin E.

[0048]Weigh 20 parts of raw land, 15 parts of scrophulariaceae, and 10 parts of black plum, mix them, crush them with a steel mill to particles with a diameter of less than 2 mm, add 5 to 10 times the volume of water, and perform ultrasonic extraction. The extraction power is 250-800W, the extraction temperature is 60-80°C, the extraction time is 60-90min, and a total of 2-3 extractions are performed. After extraction, filter through a 800-mesh filter, concentrate the filtrate to a relative density of 1.15 to 1.23, add 0.2 parts of vitamin E to make a mixed solution containing rehmannia root, scrophulariaceae, black plum and vitamin E, and then add 3% of the total mass of the mixed solution Emulsifier soybean lecithin, adjust the pH value to 6.0-7.0,...

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Abstract

The invention discloses a composition for treating atrophic rhinitis and a preparation method thereof and belongs to the technical field of traditional Chinese medicines. In the invention, according to the principle of nourishing lung and moistening dryness and activating blood and resolving stasis in traditional Chinese medicine, a simple formula is employed with a great effect for treating the atrophic rhinitis. In the composition for treating the atrophic rhinitis, three sour and sweet traditional Chinese medicines, including fructus mume, dried radix rehmanniae and scrophularia ningpoensis, are combined for nourishing yin, so that effects of nourishing yin, moistening dryness, engendering fluid, promoting hyperplasia of mucosa glands, activating bloods and resolving stasis, and promoting local blood supplement. Vitamin E can form a panniculus adiposus locally for alleviating dryness in nasal passages, improving micro-circulation in blood, providing nutrition for mucous membranes in the nasal passages and promoting the mucous membranes in the nasal passages to recover. The composition for the treating atrophic rhinitis is prepared into a nano nose-drop emulsion since an emulsifying agent is added. The composition, with tradition Chinese medicine and western medicines combined therein, is simple in components, is small in dosage, is free of toxic and side effects and is suitable for long-period usage. When being prepared into the nano nose-drop emulsion through ultrasonic extraction, the composition is stronger in effects and is longer in lasting time, and is helpful to recovery of the atrophic rhinitis and can significantly alleviating the symptoms.

Description

technical field [0001] The invention relates to a medicinal composition and a preparation method thereof, in particular to a composition for treating atrophic rhinitis and a preparation method thereof, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Atrophic rhinitis is a chronic inflammatory disease of the nasal cavity that develops slowly. It is characterized by dryness and atrophy of the nasal mucosa, enlarged nasal cavity, impaired sense of smell, and sometimes a large amount of yellow-green pus forms in the nasal cavity, and those with a bad smell are called stinky nose syndrome. Secondary atrophic rhinitis is caused by chronic rhinitis, nasal infection or surgery, severe damage to the mucosa and gradual atrophy. [0003] At present, Western medicine treatment methods mainly include: oral administration of vitamins, estrogen, antibiotics, etc. to control inflammation; epidermal growth factor, trace elements, etc. to promo...

Claims

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Application Information

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IPC IPC(8): A61K36/808A61K47/22A61P11/02A61K31/355
CPCA61K9/0043A61K9/1075A61K31/355A61K36/736A61K36/804A61K36/808A61K47/22A61K2236/15A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 夏跃虹刘进录左艳君王向云白雪飞
Owner HENAN UNIV OF SCI & TECH
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