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Nose drops taking fibrauretine as main medicine and preparation method

A kind of technology of patinarin and nasal drops, applied in the field of research and development of new pharmaceutical products

Active Publication Date: 2010-06-16
YUNNAN PHYTOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, palmatine has not yet been used in the research and application of preparations for the treatment of rhinitis, sinusitis and other nasal diseases. Only oral preparations or injections are useful for the treatment of conjunctivitis.

Method used

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  • Nose drops taking fibrauretine as main medicine and preparation method
  • Nose drops taking fibrauretine as main medicine and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Drug formulation:

[0066] Palmatine 7mg Hydroxypropyl Methyl Cellulose 10g

[0067] 0.5mol / L NaOH solution ethylparaben 0.3g

[0068] 1000mL of normal saline with a concentration of 0.9% by mass

[0069] Preparation:

[0070] Weigh 7 mg of palmatine powder and 10 g of hydroxypropyl methylcellulose; dissolve the hydroxypropyl methylcellulose using the pulping method, take 250ml of hot water at 80-90°C to swell and disperse, and add hydroxypropyl methylcellulose Stir the base cellulose for 15 minutes to make it form a uniform insoluble paste, then stir it with an equal amount of room temperature water for 15 minutes to dissolve completely; add 600 mL of palmatine powder and ethyl paraben to normal saline, heat to dissolve, and Heat suction filtration to obtain the supernatant. Stir the hydroxypropyl methylcellulose solution and the palmatine supernatant evenly, add physiological saline to make the volume to 1000mL, stir well, adjust the pH value to 6.0 with an approp...

Embodiment 2

[0072] Drug formulation:

[0073] Palmatine 20mg Hydroxypropyl Methyl Cellulose 5g

[0074] 0.5mol / L NaOH solution ethylparaben 0.3g

[0075] 1000mL of normal saline with a concentration of 0.9% by mass

[0076] Preparation:

[0077] Weigh 20 mg of palmatine powder and 5 g of hydroxypropyl methylcellulose; dissolve the hydroxypropyl methylcellulose using the pulping method, take 200 ml of hot water at 80-90 ° C to swell and disperse, and add hydroxypropyl methylcellulose Stir the cellulose-based cellulose for 20 minutes to form a uniform insoluble paste, and then stir it with an equal amount of room temperature water for 20 minutes to completely dissolve it; add 600 mL of palmatine powder and ethyl paraben to normal saline, heat to dissolve, and Heat suction filtration to obtain the supernatant. Stir the hydroxypropyl methylcellulose solution and the palmatine supernatant evenly, add physiological saline to make the volume to 1000mL, stir well, adjust the pH value to 6.5 w...

Embodiment 3

[0079] Drug formulation:

[0080] Palmatine 1mg Hydroxypropyl Methyl Cellulose 15g

[0081] 0.5mol / L NaOH solution ethylparaben 0.3g

[0082] 1000mL of normal saline with a concentration of 0.9% by mass

[0083] Preparation:

[0084] Weigh 1 mg of palmatine powder, 15 g of hydroxypropyl methylcellulose; dissolve the hydroxypropyl methylcellulose by pulping method, take 300ml of hot water at 80-90°C to swell and disperse, and add hydroxypropyl methylcellulose Stir the cellulose-based cellulose for 25 minutes to form a uniform insoluble paste, and then stir it with an equal amount of room temperature water for 25 minutes to completely dissolve it; add 600 mL of palmatine powder and ethyl paraben to normal saline, heat to dissolve, and Heat suction filtration to obtain the supernatant. Stir the hydroxypropyl methylcellulose solution and the palmatine supernatant evenly, add physiological saline to make the volume to 1000mL, stir well, adjust the pH value to 5.5 with an approp...

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Abstract

The invention relates to nose drops taking fibrauretine as a main medicine and a preparation method thereof. The nose drops comprise the following components of raw materials by weight ratio: 0.1-2% of fibrauretine and the balance auxiliary materials. The preparation method comprises the following steps: dissolving the auxiliary materials by adopting a slushing method used for hydroxypropyl methylcellulose, enabling the auxiliary materials to form a uniform insoluble paste, then adding room-temperature water with the equivalent quantity and stirring until dissolving completely; adding physiological saline into fibrauretine powder, heating, dissolving and leaching to obtain supernatant liquid; and stirring and mixing a hydroxypropyl methylcellulose solution and the supernatant liquid of the fibrauretine evenly, then adding the physiological saline, fixing the volume to the required quantity, stirring evenly, regulating the pH value to 5.5-6.5, filtering and subpackaging. By the experimental verification, the nose drops do not have an irritative inflammatory reaction, have a better suppression function to inflammation and have better stability.

Description

Technical field: [0001] The invention relates to the development of new medical products, specifically a nasal drop with palmetine as the main drug and its preparation method. Background technique [0002] 1. Introduction to chronic rhinitis [0003] Chronic rhinitis is chronic inflammation of nasal mucosa and submucosa. It manifests as chronic congestion and swelling of the nasal mucosa, which is called chronic simple rhinitis. It develops into hyperplasia and hypertrophy of nasal mucosa and turbinates, which is called chronic hypertrophic rhinitis. [0004] In patients with chronic rhinitis and sinusitis, the deep arteries of the nasal mucosa are in a state of chronic expansion and lose their contraction function. The spongy tissue of the inferior turbinate is also in a chronic expansion. There are inflammatory infiltrations mainly of lymphocytes and plasma cells around the blood vessels and glands. Active function, increased secretions, edema of the lamina propria, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/4375A61P11/02A61P31/04
Inventor 郭文李俊罗珊珊何杨松
Owner YUNNAN PHYTOPHARML
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