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Traditional Chinese medicine compound preparation for treating rhinitis and nasosinusitis and preparation process thereof

A technology for compound preparations and nasal administration preparations, which is applied in compound preparations of traditional Chinese medicine, Chinese medicine compound preparations for the treatment of rhinitis and sinusitis and its preparation field, which can solve the problems that the drug cannot reach the effective concentration, stay, and the effect is not obvious, and achieve inhibition Increased capillary permeability

Inactive Publication Date: 2012-08-22
谈钰元
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also many problems in the treatment of traditional Chinese medicine, such as a large number of oral Chinese medicine preparations, slow onset, no obvious effect, and faster improvement of symptoms than western medicine, etc. Most of the external medicines contain vasoconstrictor drugs such as ephedra, which can easily cause drug-induced rhinitis or drug withdrawal Symptoms are worse after treatment than before treatment
[0005] To sum up, although there are many drugs for treating rhinitis and sinusitis, most of them only stop at the symptoms and cannot solve the problem of recovery or recurrent rhinitis
Oral traditional Chinese medicine preparations require a large amount of prescriptions, but after the drugs are absorbed in the body, they must first be metabolized by the liver and then reach the nasal cavity through blood circulation. Most of the drugs have failed or cannot reach their effective concentration. The circulation is poor, so the curative effect is not obvious

Method used

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  • Traditional Chinese medicine compound preparation for treating rhinitis and nasosinusitis and preparation process thereof
  • Traditional Chinese medicine compound preparation for treating rhinitis and nasosinusitis and preparation process thereof
  • Traditional Chinese medicine compound preparation for treating rhinitis and nasosinusitis and preparation process thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0064] Embodiment 1 nose drops of the present invention

[0065] Raw materials: 150g of honeysuckle, 90g of cocklebur (stir-fried), 90g of scrophulariae, 60g of licorice, 1.5ml of peppermint oil.

[0066] Preparation Process:

[0067] A. Break the seed coat of Xanthium officinale, slice Scrophulariaceae and licorice, together with honeysuckle, add 12 times the amount of water to decoct twice, each time for 1 hour, filter the extract, combine; the water extract is concentrated to 1g under reduced pressure Crude drug / ml extract, the relative density at 25°C is 1.160; under stirring, add 95% ethanol to the concentrated solution to make the ethanol content to 80%, stand still for 24 hours, take the supernatant alcohol solution, filter, and recover ethanol from the filtrate, Concentrate to the equivalent of 5 kg of medicinal materials per 1 L, place at room temperature, add 3.5 times the volume of water to mix, adjust the pH value to 5.5-6.0 with 40% NaOH solution, refrigerate at ...

Embodiment 2

[0070] Embodiment 2 nasal spray of the present invention

[0071] Raw materials: 180g honeysuckle, 65g cocklebur (stir-fried), 80g scrophulariae, 45g licorice, 1.8ml peppermint oil. Preparation Process:

[0072] A. Crack cocklebur seed coat, scrophulariaceae and licorice slices, together with honeysuckle, add 9 times the amount of water to decoct twice, each time for 1.5 hours, filter the extract and combine; the water extract is concentrated to 1g under reduced pressure Crude drug / ml extract, the relative density at 25°C is 1.170; under stirring, add 95% ethanol to the concentrated solution to make the ethanol content to 80%, stand still for 24 hours, take the supernatant alcohol solution, filter, and recover ethanol from the filtrate, Concentrate until each 1L is equivalent to 5kg of medicinal materials, place at room temperature, add 3 times the volume of water to mix, adjust the pH value to 5.5-6.0 with 40% NaOH solution, refrigerate at 0-4°C for 10 hours, filter with suc...

Embodiment 3

[0075] Embodiment 3 nasal gel of the present invention

[0076] Raw materials: 120g honeysuckle, 85g cocklebur (stir-fried), 70g scrophulariae, 75g licorice, 1.2ml peppermint oil.

[0077] Preparation Process:

[0078] A. Crack cocklebur seed coat, scrophulariaceae and licorice slices, together with honeysuckle, add 14 times the amount of water to decoct twice, each time for 0.5 hours, filter the extract and combine; the water extract is concentrated under reduced pressure to 1g Crude drug / ml extract, the relative density at 25°C is 1.15; under stirring, add 95% ethanol to the concentrated solution to make the ethanol content to 80%, stand still for 24 hours, take the supernatant alcohol solution, filter, and recover ethanol from the filtrate, Concentrate until each 1L is equivalent to 5kg of medicinal materials, place it at room temperature, add 4 times the volume of water to mix, adjust the pH value to 5.5-6.0 with 40% NaOH solution, refrigerate at 0-4°C for 18 hours, filte...

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Abstract

The invention discloses a traditional Chinese medicine compound preparation for treating rhinitis and nasosinusitis and a preparation process thereof. The preparation is prepared from the following raw materials in parts by weight or in parts by volume: 100-200 parts by weight of honeysuckle, 60-120 parts by weight of cocklebur fruit, 60-120 parts by weight of radix scrophulariae, 40-80 parts by weight of liquorice and 1-2 parts by volume of dementholized peppermint oil. The raw materials are taken and conventional accessories are added to the raw materials; and then the mixture is prepared according to the conventional process into nasal delivery preparations including but not limited to nose drops, nasal spray and nasal gel. The compound traditional Chinese medicine nasal delivery preparation provided in the invention is prepared by thoroughly extracting the main active ingredients of the raw materials and has obvious curative effect for treating rhinitis (comprising acute rhinitis, chronic rhinitis and allergic rhinitis) and nasosinusitis.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine preparation, in particular to a compound traditional Chinese medicine preparation for treating rhinitis and sinusitis and a preparation process thereof, belonging to the technical field of traditional Chinese medicine pharmacy. Background technique [0002] Rhinitis refers to inflammation of the nasal mucosa and submucosal tissues. Manifested as congestion or edema, patients often have nasal congestion, runny nose, nasal itching, throat discomfort, cough and other symptoms. The performance of rhinitis is various, as acute rhinitis, chronic rhinitis and allergic rhinitis etc. Sinusitis is inflammation of the lining of the sinuses. [0003] Rhinitis and sinusitis are common and frequently-occurring diseases in the field of otolaryngology-head and neck surgery. Taking allergic rhinitis as an example, ARIA (Allergic Rhinitis and Its Impact Asthma) pointed out that the worldwide prevalence o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/808A61P11/02A61P37/08
Inventor 谈钰元
Owner 谈钰元
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