Traditional Chinese medicine compound preparation for treating rhinitis and nasosinusitis and preparation process thereof
A technology for compound preparations and nasal administration preparations, which is applied in compound preparations of traditional Chinese medicine, Chinese medicine compound preparations for the treatment of rhinitis and sinusitis and its preparation field, which can solve the problems that the drug cannot reach the effective concentration, stay, and the effect is not obvious, and achieve inhibition Increased capillary permeability
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Embodiment 1
[0064] Embodiment 1 nose drops of the present invention
[0065] Raw materials: 150g of honeysuckle, 90g of cocklebur (stir-fried), 90g of scrophulariae, 60g of licorice, 1.5ml of peppermint oil.
[0066] Preparation Process:
[0067] A. Break the seed coat of Xanthium officinale, slice Scrophulariaceae and licorice, together with honeysuckle, add 12 times the amount of water to decoct twice, each time for 1 hour, filter the extract, combine; the water extract is concentrated to 1g under reduced pressure Crude drug / ml extract, the relative density at 25°C is 1.160; under stirring, add 95% ethanol to the concentrated solution to make the ethanol content to 80%, stand still for 24 hours, take the supernatant alcohol solution, filter, and recover ethanol from the filtrate, Concentrate to the equivalent of 5 kg of medicinal materials per 1 L, place at room temperature, add 3.5 times the volume of water to mix, adjust the pH value to 5.5-6.0 with 40% NaOH solution, refrigerate at ...
Embodiment 2
[0070] Embodiment 2 nasal spray of the present invention
[0071] Raw materials: 180g honeysuckle, 65g cocklebur (stir-fried), 80g scrophulariae, 45g licorice, 1.8ml peppermint oil. Preparation Process:
[0072] A. Crack cocklebur seed coat, scrophulariaceae and licorice slices, together with honeysuckle, add 9 times the amount of water to decoct twice, each time for 1.5 hours, filter the extract and combine; the water extract is concentrated to 1g under reduced pressure Crude drug / ml extract, the relative density at 25°C is 1.170; under stirring, add 95% ethanol to the concentrated solution to make the ethanol content to 80%, stand still for 24 hours, take the supernatant alcohol solution, filter, and recover ethanol from the filtrate, Concentrate until each 1L is equivalent to 5kg of medicinal materials, place at room temperature, add 3 times the volume of water to mix, adjust the pH value to 5.5-6.0 with 40% NaOH solution, refrigerate at 0-4°C for 10 hours, filter with suc...
Embodiment 3
[0075] Embodiment 3 nasal gel of the present invention
[0076] Raw materials: 120g honeysuckle, 85g cocklebur (stir-fried), 70g scrophulariae, 75g licorice, 1.2ml peppermint oil.
[0077] Preparation Process:
[0078] A. Crack cocklebur seed coat, scrophulariaceae and licorice slices, together with honeysuckle, add 14 times the amount of water to decoct twice, each time for 0.5 hours, filter the extract and combine; the water extract is concentrated under reduced pressure to 1g Crude drug / ml extract, the relative density at 25°C is 1.15; under stirring, add 95% ethanol to the concentrated solution to make the ethanol content to 80%, stand still for 24 hours, take the supernatant alcohol solution, filter, and recover ethanol from the filtrate, Concentrate until each 1L is equivalent to 5kg of medicinal materials, place it at room temperature, add 4 times the volume of water to mix, adjust the pH value to 5.5-6.0 with 40% NaOH solution, refrigerate at 0-4°C for 18 hours, filte...
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