Chinese medicinal nose drops for treating colds and quality control method and application of preparation thereof

A technology of nasal drops and traditional Chinese medicine, applied in the field of traditional Chinese medicine, to achieve the effect of eliminating inflammation, clear mechanism, and clear antipyretic effect

Inactive Publication Date: 2010-10-06
广州中医药大学热带医学研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But still seldom use compound Chinese medicine nasal drops to prevent and treat

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation process of traditional Chinese medicine nasal drops

[0027] Prescription: Beibupleurum 50g, Houttuynia cordata 35g, licorice 15g;

[0028]Preparation method: Take Houttuynia cordata and add 80% ethanol to reflux and extract 3 times (add 20 times the amount of ethanol each time, reflux time is 30 minutes), filter, evaporate the filtrate to remove ethanol under reduced pressure, add appropriate amount of water-containing ethanol to adjust the ethanol content to 18% (v / v), and adjust the volume of the solution to be 8 times that of the medicinal material, stir evenly, let it stand for 2 days, filter, concentrate the filtrate to a thick paste, and dry it in vacuum below 80°C to obtain Houttuynia cordata extract; take licorice coarse powder , add water and decoct 3 times (add 20 times the amount of water each time, decoct for 2 hours), filter, combine the filtrates, centrifuge (15000rpm, 15min), take the supernatant and concentrate to a thick paste, and vacuum d...

Embodiment 2

[0030] Quality Control Method of Traditional Chinese Medicine Nasal Drops

[0031] (1) Qualitative identification method:

[0032] A. Take 50ml of this product, put it in a separatory funnel, extract it twice with n-butanol, 20ml each time, and place it to separate layers. Take the n-butanol solution and evaporate it to dryness under reduced pressure, add 1ml of methanol to the residue to dissolve it, and use it as the test solution; take another quercitrin reference substance, add methanol to make a reference solution containing 0.5mg per 1ml; take another Houttuynia cordata 2.5g of powder, add 40ml of methanol to reflux extraction for 30 minutes, filter, evaporate the filtrate to dryness, add 10ml of water to the residue to dissolve, extract with 10ml of n-butanol, separate the liquids; take the n-butanol liquid and evaporate to dryness under reduced pressure, add 1ml of methanol to the residue to dissolve Dissolved as the Houttuynia reference drug solution. Take 5 μl of t...

Embodiment 3

[0040] The curative effect on cold wind-heat syndrome is confirmed by clinical trials and positive drug control

[0041] The National Drug Clinical Research Base of the Affiliated Hospital of Hubei University of Traditional Chinese Medicine is the responsible unit for clinical research, and the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine and the Second Hospital of Guangdong Province of Traditional Chinese Medicine are in charge of the antiviral oral solution (batch number: 20050608) As a positive control drug, a double-simulation double-blind phase II a clinical trial observation of traditional Chinese medicine nasal drops in the treatment of cold-wind-heat syndrome (upper respiratory tract infection) was carried out. as follows:

[0042] (1) Case distribution and comparability analysis

[0043] A total of 240 patients were enrolled in the experiment, of which 11...

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PUM

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Abstract

The invention relates to Chinese medicinal nose drops for treating colds and a quality control method and application thereof. In the Chinese medicinal nose drops, radix bupleuri, houttuynia cordata thumb and liquoric root are taken as raw materials, the mass ratio of the composition raw materials of radix bupleuri to houttuynia cordata thumb to liquoric root is 50 to 35 to 15; effective positions are respectively extracted by adopting modern methods such as steam distillation, ethanol extraction, decoction by water and the like according to different properties of pharmacodynamic components of each Chinese medicament, and the nose drops are prepared by mixing the effective positions and auxiliary materials accepted by the nose drops. Simultaneously, the invention also relates to the quality control method and application of the Chinese medicinal nose drops, and discloses a qualitative identification method and a quantitative determination method of the nose drops. The Chinese medicinal nose drops have a unique formula and scientific preparation method, retain the natural characteristic of the active ingredients of the medicaments, and have the obvious effect on the treatment of colds through the administration of nasal cavities.

Description

technical field [0001] The invention relates to a preparation process, a quality control method and an application of a traditional Chinese medicine preparation, in particular to a Chinese patent medicine for treating colds-traditional Chinese medicine nasal drops made from Chinese medicinal materials, which belongs to the technical field of traditional Chinese medicine. Background technique [0002] Upper respiratory tract infection mainly refers to the general term of acute inflammation of the nasal cavity, pharynx and larynx, including common cold and influenza, and is one of the most common diseases and infectious diseases in humans. The pathogens that cause acute upper respiratory tract infection mainly include viruses and bacteria, 70-80% of which are caused by viral infections, including rhinovirus, respiratory syncytial virus, influenza virus, parainfluenza virus, coronavirus, adenovirus, etc. Mainly rhinovirus and influenza virus infection, the clinical manifestatio...

Claims

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Application Information

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IPC IPC(8): A61K36/78G01N30/90G01N21/33A61P11/00A61P31/14A61P31/16A61P31/20
Inventor 符林春胡英杰李常青张奉学朱宇同
Owner 广州中医药大学热带医学研究所
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