Temperature sensitive gel sustained-release oral agent with paracetamol

Abstract

The invention discloses a temperature sensitive gel sustained-release oral agent with a paracetamol, and relates to the technical field of pharmaceutic preparation. A carrier in the oral agent provided by the invention convenient for feeding includes paracetamol serving as an active ingredient and xyloglucan or a mixture of xyloglucan and another polysaccharide, wherein another polysaccharide is pectin, chitosan, algal polysaccharides or gellan gum. According to the invention, a polymer three-dimensional gel net structure formed by the polysaccharide is used for establishing a sustained-release system combined with clinical pathology so as to obtain the temperature sensitive gel sustained-release oral agent with the paracetamol; the temperature range for sol-gel change is 35-37 DEG C which is close to body temperature, so the oral agent is particularly suitable for old people, infants and people who have difficulty in swallowing, and has obvious efficacy. The temperature sensitive gel sustained-release oral agent disclosed by the invention has obvious analgesic and antipyretic effects, is convenient for administration and free of toxic and side effects, and the drug action can last for a long time.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an oral preparation containing paracetamol. Background technique [0002] Paracetamol, trade names include Baifuning, Biliton, Tylenol, and acetaminophen. The international non-proprietary drug name of this product is Paracetamol. It is the most commonly used non-anti-inflammatory antipyretic and analgesic drug. Its antipyretic effect is similar to that of aspirin, but its analgesic effect is weak. It has no anti-inflammatory and anti-rheumatic effects. It is the best variety among acetanilide drugs. It is especially suitable for patients who cannot use carboxylic acid drugs. It can be used for cold and fever, toothache, joint pain, neuralgia, migraine, cancer pain and post-operative pain relief. It belongs to the central nervous system drugs. [0003] At present, the oral preparations containing paracetamol that are being sold on the market or have applie...

AI Technical Summary

Problems solved by technology

Although there are many types of these preparations, there are still certain restrictions when they are used. For example, tablets, granules, and capsules are not suitable for the elderly, infants, and people who have difficulty swallowing; ordinary oral preparations do not have bioadhesion. The drug may be spit out when infants and young children take it, and the drug effect is significantly reduced

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