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Method for preparing ionic liquid and application thereof

An ionic liquid and anion technology, used in the field of medicine

Inactive Publication Date: 2019-06-18
武汉软件工程职业学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Therefore, levobupivacaine and salicylates need to be improved

Method used

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  • Method for preparing ionic liquid and application thereof
  • Method for preparing ionic liquid and application thereof
  • Method for preparing ionic liquid and application thereof

Examples

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Embodiment 1

[0058] Utilize the method of the embodiment of the present invention to prepare levobupivacaine-salicylic acid ionic liquid, the specific method is as follows:

[0059] 1. Take 4.87g levobupivacaine hydrochloride, 1.80g aspirin and 0.69g salicylic acid into 500ml ethanol solution and stir to dissolve for 40 minutes.

[0060] 2. Control the reaction temperature at 20°C, slowly add 75ml of Na with a concentration of 2mol / l dropwise at a speed of 0.5s / drop 2 CO 3 solution. After the dropwise addition, the solution was stirred for 15 minutes, and the pH value of the solution was detected to be 7.2, and the solution was colorless and transparent.

[0061] 3. Add 2.25 g of L-tartaric acid to the solution in step 2, add acetone and stir, a small amount of precipitate precipitates out, and filter.

[0062] 4. Add 200ml of ethyl acetate to the filtrate in step 3 for extraction, and rotate the extracted ethyl acetate layer at 30°C under reduced pressure to obtain a colorless, transpa...

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Abstract

The invention discloses a method for preparing ionic liquid and application thereof, wherein the method for preparing the ionic liquid comprises the steps of mixing levobupivacaine and salicylic acidtype compounds with solvents so as to obtain a mixed solution; regulating the pH value of the mixed solution so as to obtain a solution after the pH value regulation; mixing L-tartaric acid with the solution after the pH value regulation; performing filtering so as to obtain a filtered solution; performing extraction treatment on the filtered solution so as to obtain an extracted solution; performing drying rotary evaporation treatment on the extracted solution so as to obtain the ionic liquid, wherein the ionic liquid contains levobupivacaine positive ions and salicylic acid type negative ions. The ionic liquid prepared by the method has hydrochloric acid of levobupivacaine and double functions of antipyretic effect and analgesia.

Description

technical field [0001] The present invention relates to the field of medicine, in particular, to a method for preparing an ionic liquid and its application, more specifically, to a method for preparing an ionic liquid and the ionic liquid prepared by the method. Background technique [0002] Levobupivacaine hydrochloride is the L-body of bupivacaine hydrochloride, a long-acting amide local anesthetic. It is mainly used for surgical epidural anesthesia. It shows that its pharmacological properties are similar to that of bupivacaine, and its anesthetic efficacy is similar. After removing the R(+) optical isomer, the neurotoxicity and cardiotoxicity are significantly reduced, and it is safer to use. It has good application value in clinical treatment. . Salicylic acid compounds are the earliest non-steroidal anti-inflammatory drugs (NSAIDS), the most widely and persistent clinical use is aspirin and salicylic acid, aspirin and salicylic acid are easy to hydrolyze and deteriora...

Claims

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Application Information

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IPC IPC(8): C07D211/60C07C51/41C07C65/10C07C67/30C07C69/157A61P29/00
Inventor 张毅佘意陈国正金学平余磊
Owner 武汉软件工程职业学院
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