Veterinary anti-inflammation traditional Chinese medicine composition as well as preparation method and application thereof

The technology of a composition and a traditional Chinese medicine is applied in the field of veterinary anti-inflammatory traditional Chinese medicine composition and its preparation field, which can solve the problems of growth and development impact of young animals, human health impact, gastrointestinal tract damage, etc., and achieves low cost, easy operation, and promotion of release effect

Active Publication Date: 2019-03-15
重庆三峡职业学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Steroidal and non-steroidal anti-inflammatory drugs have definite clinical effects in anti-inflammation, but steroidal and non-steroidal anti-inflammatory drugs have obvious toxic side effects, such

Method used

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  • Veterinary anti-inflammation traditional Chinese medicine composition as well as preparation method and application thereof
  • Veterinary anti-inflammation traditional Chinese medicine composition as well as preparation method and application thereof
  • Veterinary anti-inflammation traditional Chinese medicine composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Preparation of veterinary anti-inflammatory traditional Chinese medicine composition

[0022] (1) Take 20 parts of gypsum and decoct in water for 0.5h, then add 20 parts of Salvia miltiorrhiza, 20 parts of honeysuckle, 10 parts of Anemarrhena, 15 parts of raw land, 10 parts of buffalo horn and 5 parts of licorice, repeat the decoction three times, and combine the three decoctions , and then concentrated to a crude drug concentration of 1g / mL to obtain a concentrated solution;

[0023] (2) Add a gelatin solution with a mass fraction of 4% to the concentrated solution obtained in step (1) until no precipitation occurs after stirring, stop adding the gelatin solution, let stand at 4°C for 24 hours, and then filter to obtain filtrate I;

[0024] (3) Add absolute ethanol to the filtrate I obtained in step (2) according to the volume ratio of absolute ethanol to filtrate I 65:100, let stand at 4°C for 24 hours, centrifuge at a speed of 3000r / min for 10min, and filter to obtai...

Embodiment 2

[0027] Test the anti-inflammatory effect of the veterinary anti-inflammatory Chinese medicine composition of the present invention

[0028] Using dexamethasone as a positive control drug, observe that the veterinary anti-inflammatory Chinese medicine composition prepared in Example 1 causes swelling of mouse auricles caused by p-xylene, increased permeability of mouse capillaries caused by acetic acid, and small Mouse toe swelling, simultaneous determination of PGE2, MDA in the inflammatory exudate of mice caused by carrageenan, and NO, SOD in serum, to explore the anti-inflammatory effect of the veterinary anti-inflammatory Chinese medicine composition prepared in Example 1 part of the mechanism.

[0029] (1) Effects of Veterinary Anti-inflammatory Chinese Medicine Composition on Mouse Auricle Swelling in Example 1

[0030] Take 30 healthy Kunming mice of 18-22 g, half male and half male, and randomly divide them into 3 groups, 10 mice in each group, respectively dexamethaso...

Embodiment 3

[0059] Test the analgesic effect of the veterinary anti-inflammatory Chinese medicine composition of the present invention

[0060] Using dexamethasone as a positive control drug, observe the writhing response of the Chinese veterinary anti-inflammatory Chinese medicine composition prepared in Example 1 to the pain induced by acetic acid in mice, and study the analgesic effect of the Chinese veterinary anti-inflammatory Chinese medicine composition.

[0061] Take 30 healthy Kunming mice of 18-22 g, half male and half male, and randomly divide them into 3 groups, 10 mice in each group, respectively dexamethasone group, veterinary anti-inflammatory Chinese medicine composition group, and blank control group. The dexamethasone group and the veterinary anti-inflammatory Chinese medicine composition group were administered by intragastric administration of 0.1mL / 10g, and the blank control group was administered with the same volume of normal saline, wherein the drug concentration of...

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Abstract

The invention relates to veterinary anti-inflammation traditional Chinese medicine composition as well as a preparation method and an application thereof, and belongs to the technical field of veterinary drugs. The veterinary anti-inflammation traditional Chinese medicine composition is prepared from components in parts by weight as follows: 20 parts of gypsum fibrosum, 20 parts of radix salviae miltiorrhizae, 20 parts of flos lonicerae, 10 parts of rhizoma anemarrhenae, 15 parts of radix rehmanniae recens, 10 parts of cornu bubali and 5 parts of radix glycyrrhizae. The traditional Chinese medicine composition has good anti-inflammation, analgesic and antipyretic effects, can reduce level of PGE2 and NO in serum, promote SOD release and inhibit synthesis and release of proinflammatory cytokines to balance expression level of proinflammatory cytokines and anti-inflammation cytokines in the serum and inhibit excessive inflammatory response, thereby playing a protective role for the body.Meanwhile, the preparation process of the veterinary anti-inflammation traditional Chinese medicine composition is simple, easy to operate, low in cost and suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a veterinary anti-inflammatory traditional Chinese medicine composition and a preparation method and application thereof. Background technique [0002] Although zoonotic diseases, parasitic diseases, obstetrical diseases, surgical diseases and medical diseases have different causes, they all have pathological characteristics of inflammation, such as cow mastitis, endometritis, trauma infection, etc. The inflammatory response of certain tissues or organs is the basis of its pathology. Inflammation is an anti-injury defense response produced by the biological body to the stimulation of various inflammatory factors, but it is also a pathological injury process. Excessive inflammatory mediators are produced during the anti-injury process, resulting in tissue and organ damage in animals. Moreover, when the body has immune dysfunction or immune deficiency, it i...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61P29/00A61K33/06A61K35/32
CPCA61K33/06A61K35/32A61K36/355A61K36/484A61K36/537A61K36/804A61K36/8964A61K2236/331A61K2236/39A61K2236/53A61P29/00A61K2300/00
Inventor 赵婵娟何先林
Owner 重庆三峡职业学院
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