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Medicine composition for treating flu and preparation method thereof

A composition and drug technology, applied in the field of medicine, can solve problems such as unclear effects and achieve good druggability

Inactive Publication Date: 2010-06-30
吴昌蔚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the influence of factors such as bioavailability, the clinical effect of using baicalin alone in the treatment of influenza is still unclear.

Method used

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  • Medicine composition for treating flu and preparation method thereof
  • Medicine composition for treating flu and preparation method thereof
  • Medicine composition for treating flu and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: Radix Glycyrrhizae antibacterial effect in vitro

[0028] Experimental drugs: glycyrrhizic acid standard product (content greater than 97%), baicalin standard product (content greater than 97%), Ganhuang tablets (optimal proportion according to the present invention).

[0029] Bacterial species: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Paratyphoid A, Streptococcus pneumoniae, Bacillus influenzae, hemolytic streptococcus.

[0030] Experimental method: Prepare the culture medium and sterilize it for later use. Take 10 clean test tubes, and prepare 10 concentrations of the drug by serial dilution method, the highest concentration is 10mg / mL. Each concentration was repeated 3 times, each series was inoculated with one type of bacteria, and each test tube was inoculated with 0.1 ml of bacteria solution. Detection of MIC (Minimum Inhibitory Concentration): Incubate the test tube inoculated with the bacterial solution at 37°C for 24 hour...

Embodiment 2

[0034] Embodiment 2: antibacterial action in vivo of Ganhuang composition

[0035] 1. Drugs and materials

[0036] Grouping: negative control group, 0.9% sodium chloride injection; baicalin group, baicalin standard preparation; glycyrrhizic acid group, glycyrrhizic acid standard preparation; Ganhuang composition group, high and low dose groups; positive control group : Shuanghuanglian oral liquid (Harbin Pharmaceutical Group Sanjing Pharmaceutical Co., Ltd., batch number: 06011832), gentamicin sulfate (Jiaozuo No. 1 Pharmaceutical Factory), three groups each, 10 rats in each group.

[0037] Animals: ICR mice, 20±2g, Experimental Animal Center of Zhejiang Academy of Medical Sciences, certificate number: SCXK (Zhejiang) 2003-0001.

[0038] Bacterial strains: Dilute Staphylococcus aureus, Escherichia coli, and Streptococcus pneumoniae suspensions with 5% peptin, and the bacterial counts are all 1010 / ml.

[0039] 2. Methods and results:

[0040] The mice were intraperitoneally ...

Embodiment 3

[0044] Embodiment 3: the anti-influenza virus effect of Ganhuang composition

[0045] 1. Experimental materials

[0046] Virus strains: Influenza A3 and B, purchased from Institute of Virology, Chinese Academy of Preventive Medicine, TCID50 (the logarithm of the virus dilution that makes half of the cell culture tubes pathological changes) is 10-3.8, 10-4.5 respectively, 100 were used during the test TCID50 / 0.1mL; mouse lung-adapted strain of influenza virus (FM1), purchased from the Institute of Virology, Chinese Academy of Preventive Medicine.

[0047] Passage cells: dog kidney MDCK cells provided by the Basic Research Office of Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences.

[0048] Animals: SPF mice, 13-15 g, Zhejiang Academy of Medical Sciences Experimental Animal Center, certificate number: SCXK (Zhejiang) 2003-0001.

[0049] Experimental drugs and reagents: ribavirin injection (Shandong Xinhua Pharmaceutical Co., Ltd., batch number: 0504005); Shuanghuangl...

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Abstract

The invention discloses a medicine composition for treating flu and a preparation method thereof. The medicine composition is mainly prepared from glycyrrhizic acid, baicalin, pseudoephedrine, taurine and other compounds. The invention has the advantages of simple medicine composition and exact curative effect; and animal experiments indicate that the medicine composition has strong inhibiting effect on influenza A virus and influenza B virus, and has the effects of killing various respiratory tract pathogenic bacteria to different degrees. The medicine composition has obvious and long-lasting antipyretic action and obviously relieves various cold symptoms, such as rhinorrhoea, snuffle, pains, cough and the like. The medicine composition has the action of synergy, can address both the symptoms and root causes against the causes and the symptoms of cold, and can obviously shorten the course of cold. The medicine composition can be made into any acceptable excipient in pharmaceutics.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a medicinal composition for treating colds and a preparation method thereof. The medicinal composition is a compound preparation composed of active ingredients of traditional Chinese medicines. Background technique [0002] A cold is an upper respiratory tract infectious disease caused by a variety of viruses or (and) bacterial infections, as well as the dual effects of low immunity of the human body. Influenza, in particular, is highly contagious and has a high incidence rate, which has a great impact on people's health and labor production. The prevention and treatment of influenza is an important research goal in the field of medicine. In terms of treatment, due to the lack of effective chemical drugs for viral infections, clinical treatment can only be symptomatic, and the curative effect is unstable and often repeated. There are many kinds of Chinese patent me...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/704A61K31/185A61K31/137A61P31/16A61P11/04A61P11/00A61P31/12A61P31/04
Inventor 吴昌蔚
Owner 吴昌蔚
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