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Pharmaceutical composition with fever relieving effect and preparation method and application thereof

A composition and drug technology, applied in the field of pharmaceutical composition with antipyretic effect and its preparation and use, can solve the problems of less attention to ingredients, and achieve high bioavailability, effective utilization, and good stability

Inactive Publication Date: 2014-11-05
CHENGDU QIANKUN VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the Bupleurum injection used in veterinary clinics is mainly the volatile oil of Bupleurum obtained by steam distillation, and less attention has been paid to the other components of Bupleurum saponins

Method used

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  • Pharmaceutical composition with fever relieving effect and preparation method and application thereof
  • Pharmaceutical composition with fever relieving effect and preparation method and application thereof
  • Pharmaceutical composition with fever relieving effect and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 Preparation of drug emulsion of the present invention

[0025] 1 Prescription process

[0026] Chinese medicinal materials: Bupleurum (the dried root of Bupleurum Chinese DC), Scutellaria baicalensis (the dried root of Scutellaria baicalensis Georgi.), purchased from Bazhong Kelun Pharmaceutical Trade Co., Ltd., after identification Conform to the relevant provisions of the Veterinary Pharmacopoeia 2010 edition. Weigh 500g of Bupleurum decoction pieces, crush them, add 6 times the amount of water, soak overnight, steam distill, collect volatile oil, seal and store for later use. In addition, 100 g of the dried Bupleurum medicinal material was mixed with 100 g of the Scutellaria baicalensis medicinal material, and after being coarsely powdered, it was frozen and ultrafinely pulverized using a YQ100 laboratory-specific small jet pulverizer ultrafine pulverizer (Shanghai Saishan Powder Machinery Manufacturing Co., Ltd.). Take an appropriate amount of superfi...

Embodiment 2

[0027] Embodiment 2 Preparation of drug emulsion of the present invention

[0028] 1 Prescription process

[0029] Chinese medicinal materials: Bupleurum (the dried root of Bupleurum Chinese DC), Scutellaria baicalensis (the dried root of Scutellaria baicalensis Georgi.), purchased from Bazhong Kelun Pharmaceutical Trade Co., Ltd., after identification Conform to the relevant provisions of the Veterinary Pharmacopoeia 2010 edition. Weigh 500g of Bupleurum decoction pieces, crush them, add 6 times the amount of water, soak overnight, steam distill, collect volatile oil, seal and store for later use. In addition, 133.3 g of the dried Bupleurum medicinal material is mixed with 66.6 g of the Scutellaria baicalensis medicinal material, and after the coarse powder, it is frozen and ultrafinely pulverized, using a YQ100 laboratory special-purpose small jet pulverizer ultrafine pulverizer (Shanghai Saishan Powder Machinery Manufacturing Co., Ltd. ). Take an appropriate amount of su...

Embodiment 3

[0030] Embodiment 3 Preparation of drug emulsion of the present invention

[0031] 1 Prescription process

[0032]Chinese medicinal materials: Bupleurum (the dried root of Bupleurum Chinese DC), Scutellaria baicalensis (the dried root of Scutellaria baicalensis Georgi.), purchased from Bazhong Kelun Pharmaceutical Trade Co., Ltd., after identification Conform to the relevant provisions of the Veterinary Pharmacopoeia 2010 edition. Weigh 500g of Bupleurum decoction pieces, crush them, add 6 times the amount of water, soak overnight, steam distill, collect volatile oil, seal and store for later use. In addition, take 66.6g of dried Bupleurum medicinal material and 133.3g of Scutellaria baicalensis medicinal material, after coarse powder, carry out freezing ultrafine pulverization, use YQ100 laboratory special-purpose small jet pulverizer ultrafine pulverizer (Shanghai Saishan Powder Machinery Manufacturing Co., Ltd.) . Take an appropriate amount of superfine powder of Scutell...

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Abstract

The invention provides a pharmaceutical composition with fever relieving effect. The composition is prepared from the following bulk drugs: 1-2 parts of bupleurum volatile oil, 1-2 parts of bupleurum extract total saponin, and 8-12 parts of a Scutellaria baicalensis extract. The invention also provides a preparation method and application of the pharmaceutical composition. The pharmaceutical composition of the invention fully improves the efficacy of bupleurum and Scutellaria baicalensis, reduces the toxicity of bupleurum; bupleurum volatile oil, bupleurum total saponins and baicalin of Scutellaria baicalensis are extracted respectively, and are finally prepared into an emulsion, which is non-toxic in certain dose and efficient and has target effect. Experiments prove that the emulsion is safe and can improve the drug efficacy.

Description

technical field [0001] The invention relates to a pharmaceutical composition with antipyretic effect. Background technique [0002] At present, the traditional Chinese medicines with antipyretic effect in the classification of traditional Chinese veterinary medicines include heat-clearing and detoxifying medicines, heat-clearing and blood-cooling medicines, heat-clearing and damp-drying medicines, and some superficial-relieving medicines. According to the different properties of the medicines, heat-clearing and detoxifying medicines have better antipyretic effects. However, most of the medicinal materials need to be used in prescriptions, and the effect of a single medicinal material cannot achieve the desired effect. [0003] In Chinese medicine, Bupleurum is mainly used to reconcile the exterior and interior, soothe the liver, and enhance the yang. For cold and fever, alternating cold and heat, malaria, liver depression and Qi stagnation, sternocostal pain, anal prolapse,...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61P29/00A61P31/12A61P1/16
Inventor 唐华侨房春林吴学渊李超杨海涵丁晓刚
Owner CHENGDU QIANKUN VETERINARY PHARMA
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