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Herba gueldenstaedtia extract and uses thereof

A technology of skin cold medicine and extract, applied in the field of skin cold medicine extract, can solve the problem of no skin cold medicine, and achieve good antipyretic effect

Inactive Publication Date: 2012-08-22
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no relevant report on the effective part of the skin cold medicine

Method used

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  • Herba gueldenstaedtia extract and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 skin cold medicine ethanol extract of the present invention

[0021] Take the rough powder of skin cold medicine, add 95% ethanol to reflux extraction twice, add 10 times the amount of alcohol for the first time, add 8 times the amount of alcohol for the second time, 3 hours each time, filter while it is hot, and combine the two filtrates , recovered to no alcohol smell, and after vacuum drying, the ethanol extract of skin cold medicine of the present invention is obtained.

[0022] In the present invention, when ethanol is used for extraction, conventional extraction techniques such as ultrasonic and microwave extraction can also be used, as long as the extraction is complete.

Embodiment 2

[0023] The preparation of embodiment 2 skin cold medicine extract of the present invention

[0024] Take the ethanol extract of skin cold medicine prepared in Example 1, add appropriate amount of water to disperse, then extract with equal volume of sherwood oil, ethyl acetate, water-saturated n-butanol successively, and extract 4 times with each solvent; collect sherwood oil respectively Extraction layer, ethyl acetate extraction layer, n-butanol extraction layer and the residue after extraction, after recovering the solvent, dry under reduced pressure at 60°C to obtain the petroleum ether part, ethyl acetate part and n-butanol part of the skin cold medicine of the present invention respectively. Extract, water phase fraction.

[0025] The above-mentioned extraction method is a commonly used system solvent method, that is, the mixture to be separated is extracted with solvents ranging from low to high polarity, and different polar extraction parts are obtained respectively.

Embodiment 3

[0026] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0027] Take the ethanol extract prepared in Example 1, add an appropriate amount of dextrin, and prepare granules;

[0028] Take the ethyl acetate extract prepared in Example 2, add an appropriate amount of dextrin, and prepare granules;

[0029] The n-butanol extract prepared in Example 2 was taken, and an appropriate amount of soluble starch was added to prepare granules.

[0030] The beneficial effects of the pharmaceutical composition of the present invention are specifically illustrated below by drug efficacy tests.

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Abstract

The invention discloses a herba gueldenstaedtia ethanol extract, which is prepared from the following method that: herba gueldenstaedtia is taken and extracted with 70-95% V / V ethanol, and a solvent is recovered from the extract so as to obtain the herba gueldenstaedtia ethanol extract. The invention also discloses a herba gueldenstaedtia ethyl acetate extract, a herba gueldenstaedtia n-butanol extract, and uses of the extracts. The herba gueldenstaedtia extracts, i.e. the herba gueldenstaedtia ethanol extract, ethyl acetate extract and n-butanol extract, have a good antipyretic effect, can be used for treating the common cold, and fever and other symptoms caused by the common cold, and provide a new drug choice for the clinic.

Description

technical field [0001] The invention relates to skin cold medicine extract and its application, belonging to the field of medicine. Background technique [0002] Skin cold medicine is a folk herbal medicine used to treat colds in the Anning River Basin of Panxi, Sichuan. The local people also call it "skin typhoid" and "chicken thigh". It comes from the Gueldenstaedtia delavayi Franch. Dried whole herb, whole herb used as medicine, can be harvested in four seasons; cold in nature, bitter in taste, clearing away heat, detoxifying and relieving pain. The term "skin cold medicine" first appeared in "Xichang Chinese Herbal Medicine", in which it is said that it is derived from the whole plant of Amblytropsis delavayi (Fr.) C.Y.Wu, a plant of the genus Papilionaceae. The Kangdian Rice Pocket is the Sichuan-Yunnan Rice Pocket Gueldenstaedtia delavayi Franch. recorded in Flora of China. However, skin cold medicine is not the same plant as the rice pocket Gueldenstaedtia multiflor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P29/00A61P11/00
Inventor 蒋桂华赵芙蓉陈孝雨彭腾宋岚邓晶晶杨莎陈佳妮兰群于忠强
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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