The invention discloses a preparation method of a granular preparation for treating a hypertensive heart disease. The granular preparation comprises the following raw material medicines: gingko leaves, amethyst, pig heart, eucommia ulmoides, taxillus sutchuenensis, longan, alpine swertia, rhizoma atractylodis macrocephalae, bark of stewartia sinensis, glossogyne tenuifolia, stachytarpheta jamaicensis, codonopsis pilosula, cinnamon, japanese banana flower, corn cervi pantotrichum, radix ophiopogonis, schisandra chinensis, astragalus membranaceus and caulis spatholobi. The dosage form is a granular preparation which is prepared from the following specific processes: mixing, grinding, boiling after soaking, and separating out a first-time decoction liquid; then, separating out the second-time decoction liquid by adopting the same method; mixing the two decoction liquids, performing centrifugal separation, drying, and adding sucrose powder and beta-cyclodextrin to prepare the mixture into the granular preparation. Compared with the prior art, the prepared granular preparation has the efficacies of promoting blood circulation to remove blood stasis, eliminating phlegm, descending turbid, calming the liver, suppressing yang, removing stasis, reducing phlegm, removing heat from the liver, nourishing kidney, nourishing liver, tonifying qi, nourishing yin, dehumidifying, removing turbidness, and supplementing benefits, and is highly targeted.