2results about How to "Relieve Toxic Side Effects" patented technology

This invention discloses a pharmaceutical composition for alleviating sotorasidib-induced intestinal injury and its uses, belonging to the field of pharmaceutical technology. This invention proposes an intervention strategy to prevent and / or alleviate sotorasidib-induced intestinal injury by activating the cAMP signaling pathway. The cAMP signaling pathway activator can restore PKA activity and / or CREB phosphorylation levels, reduce sotorasidib-induced intestinal epithelial cell apoptosis, improve cell proliferation, and alleviate intestinal barrier damage. This invention also provides a combination of the cAMP signaling pathway activator and sotorasidib for the preparation of antitumor drugs. Cell model verification showed that the combined strategy did not significantly weaken the antitumor effect of sotorasidib, suggesting that this combined strategy has the potential for application as an adjuvant protective measure.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating lung cancer bone metastasis and application thereof. The traditional Chinese medicine composition comprises the following main active ingredients in parts by mass: 20-40 parts of codonopsis pilosula, 20-40 parts of poria cocos, 20-40 parts of astragalus membranaceus, 10-30 parts of bighead atractylodes rhizome, 10-20 parts of liquorice, 10-30 parts of curcuma zedoary, 10-20 parts of pinellia ternate, 5-10 parts of pericarpium citri reticulatae, 20-40 parts of oldenlandia diffusa, 10-30 parts of fructus psoraleae, 10-30 parts of rhizoma drynariae, 10-30 parts of herba epimedii and 10-20 parts of rhizoma arisaematis. Animal experiments show that the traditional Chinese medicine composition not only can inhibit the growth of primary lesion tumors, but also can slow down the progression of bone metastatic lesion tumors, and when the traditional Chinese medicine composition is combined with chemotherapeutics for application, the tumor inhibition effect of the chemotherapeutics can be obviously enhanced, the survival time of mice can be obviously prolonged, and the curative effect of the mice is improved. And weight loss and visceral toxic and side effects caused by chemotherapeutic drugs are relieved.