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Applications of Glossogyne tenuifolia extract

A kind of grass extract and extract technology, applied in the field of plant extracts, can solve the problems of aggravated liver damage, blood sugar rise, deficiency, etc., and achieve the effect of improving drug safety, reducing side effects, and avoiding damage

Inactive Publication Date: 2020-02-07
TUNGHAI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When diabetic patients have liver damage, many hypoglycemic drugs cannot be used continuously, which is not conducive to the control of diabetes, but if the continuous use of hypoglycemic drugs will continue to aggravate liver damage, it is also very unfavorable to the health of diabetic patients
[0004] Therefore, there is currently a clinical lack of an effective ingredient that can treat liver damage caused by diabetes, and must avoid causing blood sugar to rise or aggravate liver damage

Method used

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  • Applications of Glossogyne tenuifolia extract
  • Applications of Glossogyne tenuifolia extract
  • Applications of Glossogyne tenuifolia extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Preparation of Rhizoma Fructus Extract

[0027] Samples of windweed (Glossogyne tenuifolia Cassini) were dried at 40°C for 24 hours. Take 20 g of dried fenugreek samples, grind them, mix with 200 mL of deionized water and boil for 1 hour, centrifuge the aqueous mixture (2000 rpm, 10 minutes), obtain the supernatant, and then filter, remove the residue, The extract solution was dried at a temperature of 30° C. to obtain a fenugreek extract.

Embodiment 2

[0028] Embodiment two: animal test

[0029] Eight-week-old male Wistar rats were subcutaneously injected with Streptozotocin (STZ) at a dose of 65 mg / kg, combined with nicotinamide at a dose of 230 mg / kg, and combined with a high-fat diet to induce a diabetic hyperglycemia model, and the Some diabetic hyperglycemia model rats were fed under different conditions according to the groups, as follows:

[0030] Disease group: no drugs were given;

[0031] Low-dose fenugreek extract group (referred to as low-dose group): give fenugreek extract through drinking water, the dose is 50mg / kg;

[0032] High-dose fenugreek extract group (referred to as high-dose group): give fenugreek extract through drinking water, the dose is 150mg / kg;

[0033] Drug group: administer Acarbose, a hypoglycemic drug.

[0034] The above-mentioned groups and the blank group (normal rats) were respectively fed for 4 weeks under their feeding conditions.

[0035] After the experiment was completed, the rats...

Embodiment 3

[0036] Example 3: Analysis of expression of proteins related to survival and apoptosis in each group of rats

[0037] The expression of proteins related to survival and apoptosis signaling pathways in the liver tissues of rats in each group was analyzed by Western blot method, and the results were as follows: Figure 1 to Figure 2 shown.

[0038] Depend on Figure 1 to Figure 2 The results showed that the expression of proteins related to survivin: p-PI3K and Bcl-2 in the liver tissue of rats in the disease group decreased, and the proteins related to pro-apoptosis: Cyto.C and cleaved caspase 3 Compared with the rats in the disease group, the expressions of survivin-related proteins in the liver tissue of the rats in the low-dose group, high-dose group and drug group were significantly reduced, and the expressions of survival-related proteins were respectively increased .

[0039] These results show that long-term suffering from diabetes will indeed cause liver damage, and ...

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Abstract

The invention discloses application of a Glossogyne tenuifolia extract for preparing a medicinal composition for treating and / or preventing diabetic liver diseases; therefore, the medicinal composition contains the Glossogyne tenuifolia extract in effective amount; by delivery of the medicinal composition to an individual suffered from diabetes or hyperglycemia, damage on liver tissue or cells ofthe individual can be effectively avoided.

Description

technical field [0001] The present invention relates to the second use of a plant extract, in particular to the use of an extract of fenugreek. Background technique [0002] Diabetes mellitus is currently the metabolic disease with the highest attack rate, which poses great hidden dangers to global public health. Diabetes is caused by the lack of insulin and / or insulin activity, which will produce symptoms of hyperglycemia, which will cause organ damage in patients, such as diabetic retinopathy, diabetic nephropathy and cardiovascular disease. [0003] Furthermore, diabetes can cause liver damage. Specifically, the microvessels of the liver in diabetic patients will have lesions, leading to liver ischemia and necrosis; diabetes can induce fatty liver; hypoglycemic drugs can damage liver function, etc. According to statistics, the incidence of diabetes combined with liver damage has increased to 30%. When diabetic patients suffer from liver damage, many hypoglycemic drugs c...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P1/16A61P3/10
CPCA61K36/28A61P1/16A61P3/10
Inventor 林万登
Owner TUNGHAI UNIVERSITY
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