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Effective peristrophe antipyretic petroleum ether part, preparation method and application thereof in hyperpyrexia treatment

A technology of Hydra and petroleum ether, which is applied in the preparation of medicines for treating high fever, and the field of preparation of effective antipyretic part of Hydra, which can solve the problem of reduced antibacterial efficiency, adverse reactions, and poor curative effect of medicines, etc. problems, to achieve the effect of less drug resistance, significant effect, and no adverse reactions

Inactive Publication Date: 2013-10-30
GUIYANG MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antibiotics, non-steroidal antipyretic analgesics or glucocorticoids are often used in clinical treatment, but the curative effect is not good, and many adverse reactions are prone to occur
The abuse of antibiotics has led to a decrease in the antibacterial efficiency of drugs, and drug resistance is a difficult problem to solve

Method used

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  • Effective peristrophe antipyretic petroleum ether part, preparation method and application thereof in hyperpyrexia treatment
  • Effective peristrophe antipyretic petroleum ether part, preparation method and application thereof in hyperpyrexia treatment

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Effect test

specific Embodiment approach 2

[0007] Take an appropriate amount of dried japonica, cut it into pieces, use 70% ethanol as a solvent, and use 70% ethanol as a solvent to reflux and extract twice. The amount of solvent added each time is 10 times the amount of medicinal materials. , combine the filtrates, recover the ethanol from the filtrate under reduced pressure until there is no alcohol smell, recover the organic solvent under reduced pressure with the petroleum ether extract, and concentrate under reduced pressure to obtain a thick extract, and obtain the extract of petroleum ether parts.

specific Embodiment approach 3

[0008] Take an appropriate amount of dry Hydrangea japonica, cut it into pieces, use 90% ethanol as solvent, and extract once with 90% ethanol under reflux. The amount of solvent added each time is 8 times the amount of medicinal materials. Filtrate, combine the filtrates, recover the ethanol from the filtrate under reduced pressure until there is no alcohol smell, recover the organic solvent under reduced pressure with the petroleum ether extract, and concentrate under reduced pressure to obtain a thick extract.

[0009] In order to ensure the effect of the present invention, the applicant has conducted toxicology and antipyretic pharmacodynamic studies on the petroether part of lizard grass in accordance with the relevant provisions and methods of the national "Measures for the Administration of Drug Registration", the details are as follows:

[0010] Acute toxicity test methods and results: The pet ether part of shishizao was intragastrically administered to the mice with th...

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Abstract

The invention provides an effective peristrophe antipyretic petroleum ether part, as well as a preparation method and an application thereof. The effective peristrophe antipyretic petroleum ether part is prepared from collecting fresh complete peristrophe herbs, drying the herbs in the shade, and crushing the herbs so as to obtain coarse peristrophe powder; by taking 70% of ethanol as a solvent, carrying out reflux extraction on the coarse peristrophe powder for 2-4 times in a heating manner; concentrating an extracting solution, and carrying out extraction on the extraction solution by using petroleum ether. The effective peristrophe antipyretic petroleum ether part disclosed by the invention has an obvious antipyretic effect, and especially has an effect of treating infectious hyperpyrexia caused by upper respiratory diseases, tracheal diseases, bronchial diseases and urinary system diseases.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine. In particular, it relates to the preparation method of the antipyretic and effective petroleum ether part of Hydra japonica and its application in the preparation of medicine for treating high fever. Background technique [0002] Fever is one of the common clinical diseases and frequently-occurring diseases. High fever is very harmful. When the body temperature exceeds 41 degrees Celsius, the protein in the body will decompose, causing cerebral edema and causing the death of the sick child or leaving sequelae of encephalopathy. Especially more harmful to children. Children's nervous system is not fully developed, the central nervous system has poor regulation function, the skin sweat glands are not fully developed, the body temperature regulation function is poor, and the immune system is not yet fully developed, so they are susceptible to bacterial and viral infections and cause feve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/19A61P31/04A61P29/00
Inventor 覃容贵罗忠圣范菊娣秦拴梅
Owner GUIYANG MEDICAL UNIVERSITY
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