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A kit for predicting or assisting in predicting the risk of radiation pneumonitis after lung radiation

A technology of radiation pneumonitis and reagents, applied in the field of kits for predicting or assisting in predicting the risk of radiation pneumonitis after lung radiation, to achieve the effect of easy operation, simple use and reliable results

Active Publication Date: 2022-02-25
天佳吉瑞基因科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, the biggest limiting factor in radiation therapy for lung cancer is radiation-induced lung injury.

Method used

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  • A kit for predicting or assisting in predicting the risk of radiation pneumonitis after lung radiation
  • A kit for predicting or assisting in predicting the risk of radiation pneumonitis after lung radiation
  • A kit for predicting or assisting in predicting the risk of radiation pneumonitis after lung radiation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0140] The collection of embodiment 1 clinical sample

[0141] The clinical blood samples were obtained from a hospital in Beijing. The above samples were all obtained with the informed consent of the individual. The 72 samples obtained were all from lung cancer patients before radiotherapy. Blood collection was performed in accordance with clinical routines. 1ml of venous blood was collected and stored in conventional EDTA anticoagulant tubes for no more than one week.

Embodiment 2

[0142] The identification of embodiment 2 sample genotype

[0143] Genomic DNA was extracted from the collected blood samples using a DNA extraction kit.

[0144] The 72 genomic DNAs extracted from the 72 samples in Example 1 were sequenced by the gene sequencing method, and the genotypes of the 31 single nucleotide polymorphism sites provided by the present invention were obtained.

Embodiment 3

[0145] Example 3 Calculation of Risk Score

[0146] The genotypes of the 31 sites detected in the sample in Example 2 were compared with the human reference genome version 37 (GRCh37). The original assignment of this site is 0; when the result of the alignment of this site is that one copy is consistent, the original assignment of this site is 1; when the result of the comparison of this site is that both copies are variant, the The original assignment is 2. Then the original assignment of each site is multiplied by the weight coefficient of the site (see the table below), and the resulting value is the calculated score of the site. The calculated scores of 31 sites of a sample are added, and the sum obtained is the risk value corresponding to the sample. When the sum value is greater than 0.5, it is judged that the patient will develop radiation pneumonitis of grade 2 or above. Multiplying the risk value by 100% is the risk probability of the patient suffering from grade 2...

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Abstract

The present invention relates to the field of lung cancer treatment. Specifically, it provides a kit for predicting or assisting in predicting the risk of radiation pneumonitis after lung radiation. A system for detecting the genotypes of genetic biomarkers for grade 2 or above radiation pneumonitis, in which a total of 31 genetic biomarkers can be used as detection and evaluation targets. The kit can accurately and effectively predict whether a patient’s chest tumor will cause radiation pneumonitis of grade 2 or above after receiving radiation therapy. It is easy to use, easy to operate, and the result is reliable. important guiding significance.

Description

technical field [0001] The invention relates to the field of lung cancer treatment, in particular to a kit for predicting or assisting in predicting the risk of radiation pneumonitis after lung radiation. Background technique [0002] Lung cancer is the most common cancer in men and the second most common cancer in women in my country, and it is also the most deadly tumor in my country. Radiation therapy is an important technical means of tumor treatment. With the advancement of technology, for the treatment of lung cancer, the therapeutic effect of radiotherapy can be compared with the effect of surgical treatment. Well, and the average cost of treatment is lower than surgery. With the development of the national economy, it is foreseeable that more medical institutions will introduce advanced radiotherapy equipment. At the same time, the people's demand for quality of life will increase, and radiotherapy will gradually play an increasingly important role in the field of t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/156
Inventor 曲宝林杜乐辉马娜俞伟郑晖刘湘涛贾洪涛冯亚平王乾谢剑邦蒋才杨洁
Owner 天佳吉瑞基因科技有限公司
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