43 results about "Post radiotherapy" patented technology

The invention belongs to the technical field of data processing, and particularly discloses a method and system for predicting the lifetime of a non-small cell lung cancer patient after radiotherapy, and the method comprises the steps: collecting multi-time-point imaging and hematology follow-up visit data of the patient after radiotherapy, building a longitudinal follow-up visit sequence, and mapping the longitudinal follow-up visit sequence to a unified time axis; determining a bimodal first-time significant improvement point through preset rule judgment, and constructing and standardizing an asynchronous index according to the bimodal first-time significant improvement point; then inputting a feature vector at a follow-up time point, encoding a bimodal sequence through a Transform time sequence encoder, and generating joint representation through cross-modal interaction; and finally, inputting the standardized asynchronous index, the joint representation and the clinical and radiotherapy characteristics into a DeepHit model, and outputting a patient survival distribution prediction result. According to the method, bimodal indexes can be accurately captured, time dislocation is improved, prediction accuracy and individualization degree are improved, and a reliable basis is provided for clinical prognosis evaluation.

The invention discloses a tumor radiotherapy rehabilitation nursing intervention system based on artificial intelligence, and relates to the technical field of tumor rehabilitation nursing. By integrating multi-dimensional data and combining clinical standards to output quantitative evaluation levels and key weak dimensions, rehabilitation weakness of a patient is accurately positioned, a targeted target is provided for the nursing intervention strategy generation module, a personalized scheme is generated, and pertinence and performability of intervention are ensured; policy execution data are captured in real time and a scheme is dynamically adjusted, so that the intervention process always adapts to the rehabilitation state change of a patient, and meanwhile, active management and control on high-risk groups are enhanced by periodically collecting core indexes and linking risk upgrading and priority intervention, so that the tumor radiotherapy rehabilitation nursing is changed from passive response to active pre-judgment, and the rehabilitation nursing efficiency is improved. And the overall quality of rehabilitation nursing after radiotherapy and the prognosis effect of a patient are optimized.

The invention discloses an X-ray thermoacoustic image reconstruction method based on self-supervised multi-view fusion, and relates to the technical field of medical imaging and radiotherapy dose monitoring. The method comprises the following steps: firstly, acquiring initial sound pressure distribution after radiotherapy simulation by utilizing a tissue HU value and related physical attributes, and simulating X-ray induced ultrasonic signals under different sampling conditions under a K-Wave platform so as to construct a diversified training data set, further, providing a multi-view fusion and artifact decoupling network model MFDRNet based on self-supervision, according to the model, sparse acoustic signals and image feature information can be extracted and fused at the same time, reconstructed global and local detail expressions are enhanced through a multi-scale attention mechanism, and separation of a real structure and artifact components is achieved by means of an artifact decoupling structure; in the training process, a self-supervision loss mechanism is adopted, and stable training can still be completed under the condition of lack of high-quality full-sampling labels.

The invention discloses a traditional Chinese medicine compound composition with an effect of preventing and treating radioactive injury as well as a preparation method and application thereof. The traditional Chinese medicine compound composition is prepared from 5-15 parts of American ginseng, 3-6 parts of sea-buckthorn and 10-30 parts of rhizoma polygonati. The composition is proportioned and optimized according to the theory of treatment based on syndrome differentiation, and the medicines are combined to achieve the effects of tonifying qi, activating blood and nourishing yin. Clinical experiment results show that the traditional Chinese medicine compound composition provided by the invention has a remarkable effect of preventing and treating radioactive injury, particularly has a remarkable curative effect in the aspects of improving oral mucositis, dry mouth, weakness, sleep disorder and the like after radiotherapy, and is safe in clinical medication.

This invention discloses an artificial intelligence-based intervention system for tumor radiotherapy rehabilitation nursing, belonging to the field of tumor rehabilitation nursing technology. By integrating multi-dimensional data and combining clinical standard output quantitative assessment levels and key weakness dimensions, this invention accurately identifies patients' rehabilitation shortcomings, providing targeted objectives for the nursing intervention strategy generation module and generating personalized plans to ensure the intervention's relevance and feasibility. It captures strategy execution data in real time and dynamically adjusts the plan, ensuring the intervention process always adapts to changes in the patient's rehabilitation status. Simultaneously, by regularly collecting core indicators and linking risk escalation and priority intervention, it strengthens proactive management of high-risk groups, realizing a shift from passive response to proactive prediction in tumor radiotherapy rehabilitation nursing, thus optimizing the overall quality of post-radiotherapy rehabilitation nursing and patient prognosis.

The utility model relates to the technical field of rehabilitation training, in particular to a lower limb rehabilitation training device for radiotherapy nursing, which comprises a base and a mounting seat fixed above the base, a pedal training device is arranged on the outer side of the mounting seat to provide riding training for a patient, a backrest seat is arranged above the mounting seat, and the pedal training device is connected with the backrest seat. A supporting frame is arranged on the left side of the backrest seat, a handle is fixed to the upper portion of the supporting frame, a translation pushing mechanism is arranged on the right side of the backrest seat and provides training resistance for horizontal movement of the backrest seat, and a pedal is arranged on the right side of the supporting frame and provides lower limb bending training support for a patient. According to the lower limb rehabilitation training device for radiotherapy nursing, pedal training is provided for a patient through the pedal training device, bending and straightening training of legs of the patient can be achieved through cooperation of the pedal plate and the backrest seat, two different training modes are provided for the legs of the patient, training diversity is improved, and recovery of the patient after radiotherapy is facilitated.

This application provides a method and system for predicting tumor radiotherapy response based on multi-instance learning. The method includes: constructing a radiotherapy image dataset; extracting and combining multi-dimensional features from the radiotherapy image dataset to obtain an embedded representation of the multi-dimensional features; the multi-dimensional features include two-dimensional convolutional features and three-dimensional convolutional features; constructing a Transformer-based multi-instance learning model; iteratively training the multi-instance learning model using the embedded representation of the multi-dimensional features as model input to obtain a trained multi-instance learning model; using the trained multi-instance learning model to predict the patient's mid-term radiotherapy response, and analyzing and evaluating the model prediction process using interpretable analysis, and evaluating the model prediction results for the patient's tumor region. The method provided in this application can predict the response after tumor radiotherapy, thereby intelligently assisting doctors in making precise radiotherapy decisions for patients and reducing the risk and harm to patient prognosis.

The invention belongs to the technical field of tumor radiotherapy assistance, and particularly relates to a tumor radiotherapy assistance device which comprises a radiotherapy bed, a translation plate and positioning holes. According to the invention, the radiotherapy bed is assembled at the side end of the external radiotherapy equipment through the positioning hole and the bolt body structure at the side end. The translation plate slides through a motor and a ball screw which are arranged in the radiotherapy bed, and conveys the patient to a radiotherapy area. After the patient finishes radiotherapy, if the patient is weak and inconvenient to walk, the patient can sit on the first cushion of the cart under the support of the medical staff. Afterwards, transferring is carried out through traction of medical staff. In the process, an operator only needs to pull the trigger plate with two hands, the spring bolt can be separated from the clamping groove under the supporting of the supporting shaft, and then unlocking is completed. When the cart is used for transporting and transferring a patient, due to the fact that the first cushion leaves, the second cushion needs to be pulled out from the inside of the radiotherapy bed, and the gap of the radiotherapy bed is filled up by the second cushion under the support of the spring bolt, so that a complete bed surface is formed.

The utility model discloses a skin protection device after breast radiotherapy, which comprises a first suspender and a second suspender, protective covers are connected outside the front surfaces of the first suspender and the second suspender through zippers, and an adjusting mechanism is arranged on one side of the first suspender; the adjusting mechanism comprises an adjusting shell fixedly installed on one side of the first suspender, an adjusting opening is formed in the outer wall of one side of the adjusting shell, the inner wall of the bottom of the adjusting shell is rotationally connected with a rotating shaft through a bearing, and the distance between the two protection covers can be adjusted through rotation of the rotating shaft. The protective covers of the first suspender garment and the second suspender garment can accurately protect the breast part through the rotation operation of the rotating shaft in the adjusting shell, the effectiveness of the device can be protected through fine adjustment, extra pressure or friction on a wound can be avoided, and the good protection effect on a breast cancer patient is achieved.

The invention relates to a drug molecule with a tumor treatment effect, a nano prodrug system and a preparation method and application of the drug molecule and the nano prodrug system, a CA4-DNBS structure is constructed by introducing a DNBS group into a CA4 molecule, and SO2 and CA4 can be released under the condition of high expression of GSH in tumor cells. Furthermore, near-infrared fluorescent dye ICG is introduced to form nanoparticles, so that the water solubility and biocompatibility of the prodrug are improved, and premature release of SO2 is inhibited. After entering tumor cells, the nano prodrug responsively releases SO2 under the action of GSH and consumes GSH in the cells, so that the sensitivity to chemotherapy and radiotherapy is enhanced. After intravenous injection, the nano system can improve the enrichment and release efficiency of the drug at the tumor site by virtue of a passive targeting effect. After the medicine is matched with radiotherapy, tumor growth can be remarkably inhibited through multiple synergistic effects of gas therapy, chemotherapy and radiotherapy.

The present application relates to the field of biomedical technology, and in particular to an application of a molecular marker combination in radiation pneumonitis; the application includes: using the molecular marker combination as a biomarker for radiation pneumonitis, the molecular marker combination including CXC chemokine ligand 16 and / or CC chemokine ligand 24; by performing cytokine chip detection and screening on peripheral blood specimens of multiple lung cancer patients undergoing chest radiotherapy after radiotherapy, it was found that patients with high expression of CXC chemokine ligand 16 and CC chemokine ligand 24 early after radiotherapy have a higher risk of developing radiation pneumonitis in the future, and therefore the expression levels of CXC chemokine ligand 16 and CC chemokine ligand 24 can be used to make early predictions of the occurrence of radiation pneumonitis, and therefore the above-mentioned molecular marker combination may become an early prediction tool for radiation pneumonitis in clinical practice.

The utility model relates to the technical field of rehabilitation devices, in particular to a rehabilitation device used in the rehabilitation period after tumor radiotherapy, which comprises a base, a breathing tube is mounted at the upper end of the base, a placing mechanism for placing the breathing tube is arranged at the bottom of the base, and the placing mechanism comprises a fixed block, a spring, a movable block and a placing groove. The fixed block is arranged at the bottom of the base, the two springs are fixedly connected to the two ends of the fixed block, the movable block is fixedly connected to the ends of the two springs, the containing groove is formed in the upper surface of the movable block and used for containing a breathing tube, and the face, away from the springs, of the movable block is fixedly connected with a pull ring. The fixing block and the spring are used for supporting and fixing the moving block, and the placing groove in the moving block is used for placing the breathing tube, so that the breathing tube is prevented from being in direct contact with the placing surface where the base is placed, the mouthpiece part is effectively protected, pollution caused by contact with the external environment is avoided, and the health of a patient is guaranteed.

The invention belongs to the field of new application of medicines, and particularly relates to application of Sivelestat in preparation of cancer radiotherapy adjuvant medicines. According to the invention, Sivelestat which has been used for acute respiratory distress syndrome is creatively applied to tumor radiotherapy, and the Sivelestat inhibits the activity of neutrophil elastase and effectively blocks the formation of a neutrophil outer trapping net induced by radiotherapy, so that the invasion of tumor cells and the abnormal generation of blood vessels are inhibited, and an immunosuppression microenvironment is established. The application not only maintains the local killing effect of radiotherapy on primary tumors, but also cuts off the key path from radiotherapy to NETs to metastasis from the mechanism, and significantly reduces the risk of tumor recurrence and distant metastasis after radiotherapy. The traditional Chinese medicine composition has the transformation advantage of new use of old medicines, is clear in clinical safety, and is suitable for adjuvant therapy of various solid tumors.

The expansion tool comprises a probe rod and an endoscope controller, the probe rod is formed by coaxially fixing a rod head, a rod body and a rod tail, a through cavity is formed in the probe rod in the axial direction, and outer supporting plates with hollowed-out openings and a channel expansion assembly are arranged on the circumferential face of the rod body in a circumferential array mode; the rod tail adjusting and expanding button drives a supporting rod A and a supporting rod B of the channel expanding assembly to be linked through a core ring and a movable rod, so that an outer supporting plate expands the vagina or retracts and resets; the endoscope controller insertion rod can be inserted into the expansion adjusting button insertion hole, vaginal wall images are collected through the camera, visual observation is achieved, and meanwhile flushing fluid is conveyed through the water outlet. The dilation-observation-flushing integrated operation is achieved, the dilation amplitude can be flexibly adjusted according to the vagina size and the injury degree of a patient, the patient can use the dilator independently at home through simple guidance, and the dilator is suitable for nursing of vaginal wall injury after radiotherapy and postpartum / postoperative.

The utility model discloses a post-radiotherapy exercise structure for a head and neck tumor patient, and relates to the technical field of neck exercise structures. The fixing device comprises a supporting shell, the inner wall of the supporting shell is rotationally connected with a rotating shell, the fixing device further comprises an installation mechanism, then the two sliding shells slide to drive a fixing plate to slide on the inner wall of the supporting shell to increase the distance between the fixing plate and two connecting plates, the rotating range of the rotating shell can be adjusted and limited, and then the rotating range can be adjusted according to the requirement of a patient; then first rotary knobs are reversely rotated, the two first rotary knobs drive two first threaded rods to rotate and enter a cylindrical groove to limit the rotating area of a connecting plate and a rotating shell, rotation angle adjustment and limitation can be conducted through the operation, and the risk that a patient is injured due to excessive rotation in the exercise process can be reduced; meanwhile, the angle can be adjusted according to the specific requirements of the patients, and it is ensured that each patient can obtain a proper neck exercise angle.

The invention provides a tumor radiotherapy rehabilitation data monitoring method and system, and relates to the technical field of medical data analysis. The method comprises the following steps: after first review after tumor radiotherapy treatment, acquiring first review data, an image reference risk coefficient and tumor monitoring condition reference feature information; after second review after tumor radiotherapy treatment, obtaining second review data, an image comparison risk coefficient and tumor monitoring condition comparison feature information; and determining whether further examination is needed, and if so, determining the type of the further examination according to the tumor monitoring condition reference feature information and the tumor monitoring condition comparison feature information. According to the invention, after radiotherapy, the reference information and the comparison information can be respectively obtained after first reexamination and second reexamination, and whether further examination needs to be carried out is determined, so that the probability of missing detection is reduced, a proper examination scheme can be selected, and the possibility of extra injury to a patient or overhigh examination cost caused by excessive examination is reduced.

The application provides a method for constructing a nasopharyngeal carcinoma tumor-bearing rat model with increased nasal cavity secretion, and the rat model is constructed by subcutaneous injection of murine nasopharyngeal carcinoma cells (FAT) and local irradiation by X-ray irradiation. The rat model constructed by the method has both the tumor-bearing state of nasopharyngeal carcinoma and the side effect state of increased nasal cavity secretion after radiotherapy, and the immune system still exists, and is suitable for the research on the effect and mechanism of drugs, especially traditional Chinese medicines, for exerting a therapeutic effect by immunity.

This invention relates to the field of biomedical technology, disclosing a drug combination and its application for improving the sensitivity of FLASH radiotherapy in the treatment of colorectal cancer peritoneal metastases. The combination comprises a therapeutically effective amount of an APOE inhibitor and / or an IL1B agonist. By combining an APOE inhibitor and / or an IL1B agonist, this invention can precisely target and intervene in abnormal gene expression after FLASH radiotherapy, thereby improving the abnormal gene expression state after FLASH radiotherapy, eliminating the negative impact of abnormal gene expression on the efficacy of radiotherapy, significantly improving the therapeutic sensitivity of FLASH radiotherapy to colorectal cancer peritoneal metastases, achieving radiosensitization, and providing a new targeted strategy for the radiotherapy treatment of colorectal cancer peritoneal metastases.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a medicated pack for local edema after tumor surgery and radiotherapy, and its preparation method. The medicated pack comprises the following raw materials in parts by weight: Astragalus membranaceus 20-30 parts, Paeonia lactiflora 20-30 parts, Glauber's salt 20-30 parts, Poria cocos 15-20 parts, Curcuma longa 15-20 parts, Borneol 10-15 parts, Typha pollen 10-15 parts, self-heating matrix 20-40 parts, hyaluronic acid 30-70 parts, and glycerin 50-80 parts. The traditional Chinese medicines used have the effects of promoting diuresis and reducing swelling, promoting blood circulation and removing blood stasis, and anti-inflammatory and analgesic properties. The prepared self-heating matrix has the characteristics of continuous and controllable hygroscopic and heat-releasing properties, which can promote the formation of a gel state in the medicated pack during use, providing a warm environment for the transdermal transdermal absorption of the active ingredients of the traditional Chinese medicine, effectively improving the symptoms of local edema after tumor surgery and radiotherapy, and has high clinical application value.

This invention discloses a method for radiotherapy target localization based on biodegradable radiopaque ceramic markers. The method involves customizing and standardizing biodegradable radiopaque ceramic markers to match the radiotherapy cycle, based on pre-defined tumor lesion parameters and full-cycle radiotherapy parameters. Target area image data of the implanted non-coplanar markers are acquired, and coordinate system registration, precise target delineation, and radiotherapy planning parameters are determined based on CT thin-slice images. Before radiotherapy, the markers are used to verify their position, and positioning correction parameters are output for radiotherapy equipment calibration. After radiotherapy, the degradation of the markers is monitored based on follow-up images. This invention achieves precise radiotherapy target localization, uses markers without artifact imaging, has a degradation cycle precisely matched to the radiotherapy cycle, is completely degradable without the need for secondary surgery, and exhibits excellent biocompatibility.

The application discloses a non-small cell lung cancer fractionated radiotherapy progress prediction method based on a mathematical mechanism model, which is based on in-depth research on tumor proliferation mechanism and radiotherapy killing effect, and simultaneously carries out segmented integral analysis on the fractionated radiotherapy process, constructs a mathematical mechanism model considering dynamic growth change of tumor volume in the fractionated radiotherapy process, and realizes non-small cell lung cancer fractionated radiotherapy progress prediction by using the mathematical mechanism model. The application can use low-cost python software to realize one-key personalized simulation of NSCLC fractionated radiotherapy progress, provides a new visual angle of numerical simulation for doctors, accurately predicts the volume change of the tumor of a patient after fractionated radiotherapy, and provides a recommended scheme, potential opportunity, reference dose and interval frequency and the like for intervention and intervention of radiotherapy planning.

The invention provides a tooth socket and a preparation method of a dendrobium officinale extracting solution administration tooth socket. The tooth socket at least comprises a tooth socket body and a liquid storage sheet. The tooth socket body comprises an upper jaw tooth socket and a lower jaw tooth socket, the upper jaw tooth socket and the lower jaw tooth socket are provided with occlusal surfaces, a medicine groove is formed in the side, away from the occlusal surfaces, of the upper jaw tooth socket, the upper jaw tooth socket and the lower jaw tooth socket are connected at the ends, and an elastic element is arranged at the connecting position. And the occlusion directions of the upper jaw tooth socket and the lower jaw tooth socket are opposite. And the liquid storage sheet is arranged on the occlusal surface of the upper jaw tooth socket and is communicated with the medicine groove. The device is suitable for patients suffering from local mucosal lesion related reactions during radiotherapy and after radiotherapy, drug action time can be prolonged through continuous dynamic drug delivery, targeted delivery can be achieved, drug effective components make continuous contact with the oral ulcer part of the patient at the same concentration, local treatment efficiency is improved, oral muscle strength training is synchronously carried out, and the treatment effect is improved. The oral cavity function of the patient can be maintained, and the completion rate of radiotherapy can be improved.

The utility model provides a post-radiotherapy oral occlusion exerciser for a head and neck tumor patient. The post-radiotherapy oral occlusion exerciser comprises a body and a fixing belt, the body is a trapezoid table and comprises a first face and a second face, the first face faces the inner side of an oral cavity, the area of the first face is smaller than that of the second face, protruding edges are symmetrically arranged on an upper inclined face and a lower inclined face which are opposite to each other of the body, fixing belts are fixed to the inclined faces on the two sides of the body respectively, and an elastic ball is arranged in the body. According to the distance of the mouth-opening exerciser placed in the oral cavity, mouth-opening exercises can be performed step by step, progressive exercises are realized, and the purpose of mouth-opening exercises is achieved by ensuring that each step is prevented from slipping and teeth are limited during occlusion through the arranged convex edges. Through the elasticity of the bouncy ball, masticatory muscle groups of the jaw are exercised during occlusion exercise, and muscle recovery is promoted. The fixing band of the body is convenient for fixing the body during use, the two hands are liberated, the hand fatigue caused by hand holding is avoided, the length of the fixing band can be adjusted, and the device is suitable for patients with different head circumferences and patients.

This invention relates to the field of damage assessment technology, specifically to an intelligent assessment method and system for the degree of tumor tissue damage after radiotherapy. The method includes the following steps: based on the radiation dose distribution and voxel grayscale information output by the radiotherapy equipment, temporal pairing and spatial indexing are completed; then, grayscale changes are analyzed to determine the tumor boundary; grayscale and dose characteristics are statistically analyzed layer by layer; spatial localization items of sensitive layers are identified; damage grading parameters are adjusted; and damage grading classification markers are output. This invention dynamically registers the spatial structure of radiation dose with voxel grayscale data to establish a multi-ring layer parameter set for the tumor and adjacent tissues, achieving layered localization and extracting key spatial features. It directly correlates dose distribution differences with damage grading adjustment parameters. Combined with spatial markers and grading standards, it can accurately classify the radiation response of the tumor boundary and adjacent sensitive areas, completing a detailed determination of the damage level and improving the structured expression and multi-dimensional identification capabilities of the assessment results.

The application discloses an X-ray activated tumor immune metabolism regulation and pyroptosis synergistic bacteria outer membrane vesicle and a preparation method and application thereof, and belongs to the technical field of biotechnology.The application introduces an azido group on the surface of the bacteria outer membrane vesicle through metabolic sugar engineering technology, modifies PEG, a singlet oxygen sensitive linkage and an immune metabolism regulator on the surface of the bacteria outer membrane vesicle in sequence through a click chemistry reaction, and further modifies an X-ray sensitive drug on the bacteria outer membrane vesicle, generates singlet oxygen by irradiating the tumor site with X-rays, causes the singlet oxygen sensitive linkage to break, responsively releases an IDO inhibitor, effectively blocks T cell inhibition induced by high expression of IDO after radiotherapy and restores strong T cell response, reverses the tumor immunosuppressive microenvironment caused by radiotherapy, and simultaneously induces pyroptosis of tumor cells by lipopolysaccharide on the bacteria outer membrane vesicle, further activates the immune response of the body and enhances the radiotherapy effect.

The application discloses a head and neck radiotherapy patient mouth opening difficulty degree evaluation system based on image enhancement, which comprises an image acquisition module, a mouth opening image enhancement module, a mouth opening image segmentation module and a mouth opening difficulty degree evaluation module. The application belongs to the field of image processing, and particularly relates to a head and neck radiotherapy patient mouth opening difficulty degree evaluation system based on image enhancement. The scheme adopts a sampling strategy based on sensitivity weight, alleviates the problem of subsequent evaluation influenced by class imbalance, introduces a local attenuation compensation term, and corrects based on a multi-scale degradation feature extraction unit and an adaptive modulation parameter generation unit. Based on a constructed regional penalty loss and a boundary distance weighted boundary numerical supervision loss, global and local information are taken into account, and the features of edge blur and local morphology difference commonly existing in the images of patients after radiotherapy are adapted, so that the subsequent head and neck radiotherapy patient mouth opening difficulty degree evaluation effect is improved.

The present invention discloses an oral liquid for post-illness and post-chemotherapy immune regulation and its preparation method, relating to the technical field of health care products. The oral liquid comprises the following ingredients: astragalus, ganoderma lucidum, licorice, chrysanthemum, coix seed, and oyster. By optimizing the formulation and extraction method, the oral liquid enhances immunity and mitigates adverse reactions after radiotherapy. Furthermore, the ingredients are safe, have no adverse effects on the liver, and offer enhanced storage stability for the active ingredients.

The invention discloses a multi-sensing feedback type intelligent vagina rehabilitation training device and a training method thereof.The device comprises a plug-in rehabilitation execution end, a control host, an integrated flushing pipeline, a pump control type expansion assembly, a multi-sensing assembly, a built-in data processing module, a control module, an expansion driving pump body and a flushing pump body; case data, vagina internal images and physiological parameters are collected in multiple dimensions, similar cases are matched after preprocessing, a personalized rehabilitation scheme is generated in combination with functional state levels and individual characteristics, and training parameters and rehabilitation auxiliary medicine dosage are dynamically optimized based on a rehabilitation progress evaluation result. The system integrates flushing administration, expansion training, real-time monitoring, scheme generation and dynamic optimization functions, solves the problems of single function, insufficient scheme pertinence and lack of real-time feedback pain points of traditional equipment, improves the rehabilitation effect and safety, reduces the cost of seeing a doctor for a user, and is suitable for popularization and application. The device is suitable for household rehabilitation of various vaginal dysfunction users after postpartum, climacteric, radiotherapy and the like.

This invention discloses the application of hsa-miR-92b-5p as a biomarker for radiosensitivity in low-grade gliomas. The inventors found that high expression of hsa-miR-92b-5p indicates radioresistance in patients with low-grade gliomas, a high risk of recurrence after radiotherapy, and a poor prognosis. hsa-miR-92b-5p can serve as a biomarker for radioresistance in low-grade gliomas, enabling personalized radiotherapy for these tumors, improving treatment efficacy, and avoiding ineffective treatment.

The invention relates to the technical field of tumor nursing, in particular to a method for improving sleep of a breast cancer patient through combination of aroma regulation and abdominal arrest respiration, which comprises the following four links: S1, mixing three essential oils, adding gamma-aminobutyric acid, stirring for reaction, adding beta-cyclodextrin to prepare an inclusion compound, cooling, adding traditional Chinese medicine extract and purified water, ultrasonically dispersing, filtering, preserving heat and regulating pH to obtain an essential oil solution; standing to obtain a compound preparation; s2, adjusting the temperature, humidity, light and noise of a ward two days before radiotherapy, debugging an aromatherapy machine, and adding a preparation for preheating; s3, performing staged aromatherapy 1.5 hours before sleep, and synchronously guiding abdominal arrest breathing; and S4, inspecting and monitoring the heart rate every 15 minutes, evaluating and adjusting every 7 days, and continuing to 1 week after radiotherapy. According to the method, synergistic sleep aiding of chemical sedation and traditional Chinese medicine conditioning is achieved through a compound preparation, negative emotion is relieved through staged aromatherapy and respiratory training, and safety is improved through personalized evaluation; the traditional Chinese medicine composition is free of medicine dependence, improves sleep and emotion, adapts to the radiotherapy period and is high in patient compliance.