15 results about "Post radiotherapy" patented technology

This invention discloses an artificial intelligence-based intervention system for tumor radiotherapy rehabilitation nursing, belonging to the field of tumor rehabilitation nursing technology. By integrating multi-dimensional data and combining clinical standard output quantitative assessment levels and key weakness dimensions, this invention accurately identifies patients' rehabilitation shortcomings, providing targeted objectives for the nursing intervention strategy generation module and generating personalized plans to ensure the intervention's relevance and feasibility. It captures strategy execution data in real time and dynamically adjusts the plan, ensuring the intervention process always adapts to changes in the patient's rehabilitation status. Simultaneously, by regularly collecting core indicators and linking risk escalation and priority intervention, it strengthens proactive management of high-risk groups, realizing a shift from passive response to proactive prediction in tumor radiotherapy rehabilitation nursing, thus optimizing the overall quality of post-radiotherapy rehabilitation nursing and patient prognosis.

The utility model relates to the technical field of rehabilitation training, in particular to a lower limb rehabilitation training device for radiotherapy nursing, which comprises a base and a mounting seat fixed above the base, a pedal training device is arranged on the outer side of the mounting seat to provide riding training for a patient, a backrest seat is arranged above the mounting seat, and the pedal training device is connected with the backrest seat. A supporting frame is arranged on the left side of the backrest seat, a handle is fixed to the upper portion of the supporting frame, a translation pushing mechanism is arranged on the right side of the backrest seat and provides training resistance for horizontal movement of the backrest seat, and a pedal is arranged on the right side of the supporting frame and provides lower limb bending training support for a patient. According to the lower limb rehabilitation training device for radiotherapy nursing, pedal training is provided for a patient through the pedal training device, bending and straightening training of legs of the patient can be achieved through cooperation of the pedal plate and the backrest seat, two different training modes are provided for the legs of the patient, training diversity is improved, and recovery of the patient after radiotherapy is facilitated.

The invention belongs to the field of new application of medicines, and particularly relates to application of Sivelestat in preparation of cancer radiotherapy adjuvant medicines. According to the invention, Sivelestat which has been used for acute respiratory distress syndrome is creatively applied to tumor radiotherapy, and the Sivelestat inhibits the activity of neutrophil elastase and effectively blocks the formation of a neutrophil outer trapping net induced by radiotherapy, so that the invasion of tumor cells and the abnormal generation of blood vessels are inhibited, and an immunosuppression microenvironment is established. The application not only maintains the local killing effect of radiotherapy on primary tumors, but also cuts off the key path from radiotherapy to NETs to metastasis from the mechanism, and significantly reduces the risk of tumor recurrence and distant metastasis after radiotherapy. The traditional Chinese medicine composition has the transformation advantage of new use of old medicines, is clear in clinical safety, and is suitable for adjuvant therapy of various solid tumors.

This invention relates to the field of biomedical technology, disclosing a drug combination and its application for improving the sensitivity of FLASH radiotherapy in the treatment of colorectal cancer peritoneal metastases. The combination comprises a therapeutically effective amount of an APOE inhibitor and / or an IL1B agonist. By combining an APOE inhibitor and / or an IL1B agonist, this invention can precisely target and intervene in abnormal gene expression after FLASH radiotherapy, thereby improving the abnormal gene expression state after FLASH radiotherapy, eliminating the negative impact of abnormal gene expression on the efficacy of radiotherapy, significantly improving the therapeutic sensitivity of FLASH radiotherapy to colorectal cancer peritoneal metastases, achieving radiosensitization, and providing a new targeted strategy for the radiotherapy treatment of colorectal cancer peritoneal metastases.

This invention discloses a method for radiotherapy target localization based on biodegradable radiopaque ceramic markers. The method involves customizing and standardizing biodegradable radiopaque ceramic markers to match the radiotherapy cycle, based on pre-defined tumor lesion parameters and full-cycle radiotherapy parameters. Target area image data of the implanted non-coplanar markers are acquired, and coordinate system registration, precise target delineation, and radiotherapy planning parameters are determined based on CT thin-slice images. Before radiotherapy, the markers are used to verify their position, and positioning correction parameters are output for radiotherapy equipment calibration. After radiotherapy, the degradation of the markers is monitored based on follow-up images. This invention achieves precise radiotherapy target localization, uses markers without artifact imaging, has a degradation cycle precisely matched to the radiotherapy cycle, is completely degradable without the need for secondary surgery, and exhibits excellent biocompatibility.

This invention relates to the field of damage assessment technology, specifically to an intelligent assessment method and system for the degree of tumor tissue damage after radiotherapy. The method includes the following steps: based on the radiation dose distribution and voxel grayscale information output by the radiotherapy equipment, temporal pairing and spatial indexing are completed; then, grayscale changes are analyzed to determine the tumor boundary; grayscale and dose characteristics are statistically analyzed layer by layer; spatial localization items of sensitive layers are identified; damage grading parameters are adjusted; and damage grading classification markers are output. This invention dynamically registers the spatial structure of radiation dose with voxel grayscale data to establish a multi-ring layer parameter set for the tumor and adjacent tissues, achieving layered localization and extracting key spatial features. It directly correlates dose distribution differences with damage grading adjustment parameters. Combined with spatial markers and grading standards, it can accurately classify the radiation response of the tumor boundary and adjacent sensitive areas, completing a detailed determination of the damage level and improving the structured expression and multi-dimensional identification capabilities of the assessment results.

The invention discloses a multi-sensing feedback type intelligent vagina rehabilitation training device and a training method thereof.The device comprises a plug-in rehabilitation execution end, a control host, an integrated flushing pipeline, a pump control type expansion assembly, a multi-sensing assembly, a built-in data processing module, a control module, an expansion driving pump body and a flushing pump body; case data, vagina internal images and physiological parameters are collected in multiple dimensions, similar cases are matched after preprocessing, a personalized rehabilitation scheme is generated in combination with functional state levels and individual characteristics, and training parameters and rehabilitation auxiliary medicine dosage are dynamically optimized based on a rehabilitation progress evaluation result. The system integrates flushing administration, expansion training, real-time monitoring, scheme generation and dynamic optimization functions, solves the problems of single function, insufficient scheme pertinence and lack of real-time feedback pain points of traditional equipment, improves the rehabilitation effect and safety, reduces the cost of seeing a doctor for a user, and is suitable for popularization and application. The device is suitable for household rehabilitation of various vaginal dysfunction users after postpartum, climacteric, radiotherapy and the like.

This invention relates to the application of DTX3 or reagents that promote DTX3 expression in the preparation of products reversing radioresistance in nasopharyngeal carcinoma (NPC), belonging to the field of biomedical technology. The invention found that, compared to parental NPC cells, Deltex E3 ubiquitin ligase 3 (DTX3) expression is significantly reduced in radioresistant NPC. Overexpression of DTX3 can reverse radioresistance in NPC cells and inhibit homologous recombination repair after radiotherapy in NPC, thus allowing DTX3 to be used to reverse radioresistance in NPC. This invention provides a new biomarker for the diagnosis of radiotherapy response in NPC, an effective method for reversing radioresistance in NPC, and a new treatment option for NPC.

The invention belongs to the field of biomedicine, and particularly relates to application of Ptpn6 knockout macrophages in breast cancer radiotherapy sensitization. Through experimental verification for the first time, Ptpn6 is determined as a key new target for regulating and controlling radiation response and functional phenotype of macrophages. The Ptpn6 gene of the macrophage is knocked out through a gene editing technology, the radiation resistance of the macrophage can be enhanced, the macrophage can continuously survive in a microenvironment after radiotherapy, the macrophage can be reprogrammed into an anti-tumor M1 sample phenotype from a tumor promoting M2 phenotype, and then the anti-tumor immunocompetence of the macrophage is enhanced. In-vitro and in-vivo experiments prove that compared with wild type macrophages, the Ptpn6 knockout macrophages can be used as a cell sensitizer to be combined with radiotherapy, so that the proliferation of tumor cells can be more effectively inhibited, the apoptosis of the tumor cells can be promoted, and the growth of in-vivo tumors can be obviously inhibited. A brand new cell treatment strategy is provided for overcoming breast cancer radiotherapy resistance.

The utility model discloses an oral cavity washing observation device for tumor patients after radiotherapy, which relates to the technical field of medical instruments and comprises a support plate, a support is fixedly arranged on one side of the top end of the support plate, a rotating rod is rotatably arranged at the top of the support, a support is fixedly arranged in the middle of the rotating rod, and a lower jaw plate is fixedly arranged at the top end of the support. An adjusting assembly for adjusting the lower jaw plate is arranged on one side of the support, a water storage tank is arranged below the supporting plate, and a heating rod is arranged in the water storage tank; the flushing treatment device has the advantages that the position of the lower jaw plate is flexibly adjusted according to individual requirements of patients, treatment adaptability and patient satisfaction are improved, and different patients can conveniently obtain the best comfort experience when receiving flushing treatment; it is ensured that the water body is kept in a proper heating state for use, stimulation of cold water to oral mucosa is avoided, and the recovery process of oral tissue is possibly promoted to a certain extent.

The invention provides temperature-sensitive hydrogel for vaginal repair after radiotherapy and a preparation method thereof, and belongs to the technical field of medical gel. The hydrogel disclosed by the invention comprises the following components in percentage by weight: 20%-36% of poloxamer 407, 7%-15% of poloxamer 188, 8%-13% of hydroxypropyl methyl cellulose, 1%-5% of an active compound and the balance of water, wherein the active compound comprises ligustrazine, paclitaxel and anemonin. The temperature-sensitive hydrogel is in a liquid state at room temperature or low temperature, is subjected to phase change after entering the vagina to form semi-solid gel, is adhered to the surface of vaginal mucosa, forms a physical barrier, protects and repairs damaged mucosa, releases active ingredients slowly, exerts efficacy for a long time, reduces drug loss, improves local drug concentration, and has a good application prospect. The traditional Chinese medicine composition can be used for repairing the vagina after radiotherapy with a small dosage, delaying the occurrence time of vaginitis, shortening the illness period of a patient and improving the living quality of the patient.

The application belongs to the technical field of data processing, and specifically discloses a non-small cell lung cancer patient survival time prediction method and system after radiotherapy, which comprises the following steps: collecting multi-time point imaging and hematological follow-up data of patients after radiotherapy, establishing a longitudinal follow-up sequence and mapping to a unified time axis; determining the first significant improvement point of the double mode through preset rule determination, constructing and standardizing the asynchronous index accordingly; then inputting the feature vector at the follow-up point, encoding the double mode sequence through the Transform time sequence encoder, and generating the joint representation through the cross-modal interaction; finally, inputting the standardized asynchronous index, the joint representation and the clinical and radiotherapy characteristics into the DeepHit model, and outputting the patient survival distribution prediction result. The application can accurately capture the double mode index improvement time dislocation, improve the prediction accuracy and individualization degree, and provide a reliable basis for clinical prognosis evaluation.

The invention discloses a platelet self-driven bacterial outer membrane bionic gas delivery system and a preparation method. The delivery system comprises a CO donor and bacterial outer membrane vesicles (OMV), the CO donor is loaded in the OMV, and the OMV loaded with the CO donor forms a first nano particle; the DSPE-PEG-PSN polypeptide is embedded into the OMV lipid bilayer of the first nano particle, so that the second nano particle is formed. According to the delivery system, direct intravenous injection can be achieved, the inflammation tendency effect of platelets after radiotherapy is utilized, safe, efficient and accurate delivery of the OMV bionic CO tumor site is achieved, it is avoided that OMV and CO leak in advance in the delivery process, finally, the medicine accumulation amount of the tumor site is effectively increased, and CO gas is slowly released in the tumor microenvironment after radiotherapy; the compound can also cooperate with the immunostimulation effect of OMV, significantly enhance the systemic immune effect after radiotherapy, and further effectively inhibit tumor recurrence and metastasis.

The application discloses a radiation-proof and oxidation-resistant coating, a helmet probiotic and a preparation method and application thereof, and relates to the technical field of probiotics, and specifically discloses a radiation-proof and oxidation-resistant coating which comprises a plurality of bismuth oxide particles, the surface of the bismuth oxide particles is coated with a metal polyphenol network layer formed by the reaction of polyphenols and trivalent cerium ions, and the metal polyphenol network layer is used for connecting the coated bismuth oxide particles to intestinal probiotics. The helmet probiotic of the application can be long-acting and fixed in the intestinal tract and carries a coating with radiation-proof and oxidation-resistant functions, can effectively prevent the damage to the intestinal tract during radiotherapy, can significantly reduce the oxidative stress reaction after radiotherapy, can reduce the inflammatory reaction, can protect the intestinal tissue, and can improve the survival level of tumor patients after recovery.

The invention provides a lung cancer radiotherapy target area self-adaptive sketching method, and belongs to the field of image processing, and the method comprises the steps: obtaining a lung CT image of a lung cancer patient before each radiotherapy, and sketching a radiotherapy target area in the lung CT image before the first radiotherapy, comparing the lung CT image of the lung cancer patient before each radiotherapy with the lung CT image of the lung cancer patient during the previous delineation of the radiotherapy target region, and judging whether the radiotherapy target region is delineated again or not during each radiotherapy; if sketching is carried out again, sketching of the radiotherapy target area is completed according to the difference between the lung CT image before the radiotherapy and the lung CT image in the last sketching and the edge voxels of the radiotherapy target area sketched in the last sketching. The objective of the invention is to solve the problem that when a lung cancer radiotherapy target region determined by a lung CT image before radiotherapy is used as a lung cancer radiotherapy target region after multiple times of radiotherapy, the matching degree between the radiotherapy target region and a tumor may be low.