59 results about "Post radiotherapy" patented technology

The invention belongs to the technical field of medical appliances, and in particular relates to a post-radiotherapy oral rehabilitation trainer. The post-radiotherapy oral rehabilitation trainer comprises a square training body and a trapezoidal training body, wherein the square training body comprises a nut tube socket and a thread tube socket which is in threaded connection with the nut tube socket; two side surfaces of the trapezoidal training body are rectangles with different areas, and the height of the side surface with a greater area is consistent with that of the nut tube socket; the side surface with a greater area of the trapezoidal training body is fixedly connected with one side of the nut tube socket, and the side surface with a smaller area of the trapezoidal training body is provided with a gargle spray orifice which is communicated with a gargle guide tube; a passage for the gargle guide tube to pass through is respectively arranged at parts close to the bottoms in the trapezoidal training body and the nut tube socket; and a piston and a push-pull rod which is connected with the piston are arranged in the gargle guide tube. The post-radiotherapy oral rehabilitation trainer is simple in structure, convenient to use, flexible to operate, capable of reducing inflammation of oral ulcers, and good in rehabilitation effect.

The invention provides a preparation method of antitumor microparticles. The preparation method comprises steps as follows: 1), in-vitro tumor cells are obtained and subjected to primary tumor cell culture, and primary tumor cells are obtained; 2), the primary tumor cells obtained in step 1) and a culture solution are subjected to radio therapy irradiation, a supernatant after radio therapy is collected, and a mixture of the required microparticles and apoptotic tumor cell debris is obtained; 3), the mixture obtained in step 2) is centrifuged, and the antitumor microparticles are obtained. Theinvention further provides a drug containing the antitumor microparticles. The drug is prepared from the antitumor microparticles by purification and concentration. The antitumor microparticles prepared with the preparation method of the antitumor microparticles can be used for preparing an antitumor drug. The technical problems of poor effect, heavy side effects and high probability of drug resistance of conventional local chemotherapy can be solved.

The invention discloses an upper limb nursing exercise device after radiotherapy. The upper limb nursing exercise device after radiotherapy comprises a base, wherein a groove is formed in the base; afirst support plate and a second support plate are arranged above the base; one end of the first support plate is hinged to the base; the other end of the first support plate is hinged to the second support plate; a separation plate is fixedly arranged in the groove; load bearing sponge is arranged in the groove formed in the lower side of the first support plate; an angle regulating structure isarranged in the groove formed in the lower side of the second support plate; an upper limb exercise structure is arranged above the first support plate; a cavity is formed inside the second support plate; and a massage structure is arranged in the cavity. The upper limb nursing exercise device after radiotherapy is provided with the upper limb exercise structure; a patient holds a pulling ring byhand and downwards pulls the pulling ring by force to do arm exercises; the self immunity recovery of the patient after the radiotherapy is facilitated; a massage structure is arranged in the second support plate, and can be used for massaging the arms of the patient, so that the unsmoothness of blood circulation because the arms are put onto the device for too long time is prevented; and meanwhile, the comfort degree of the patient is improved.

The invention relates to the field of lung cancer treatment, in particular to genetic biomarkers for predicting or assisting in predicting the risk of radiation pneumonitis after pulmonary radiation,and application of the genetic biomarkers. The genetic biomarkers comprise single-nucleotide polymorphic sites from RP2-01 to RP2-31; and the group of the genetic biomarkers fills in the absence of abiomarker which can be used for predicting the risk of radiation pneumonitis after the pulmonary radiation in patients in the prior art. The group of the single-nucleotide polymorphic sites is of different genotypes in different individuals; the different genotypes can affect the sensitivity of normal lung tissues to radiation; by detecting and evaluating the sites, a prognosis can be assisted; and the genetic biomarkers are of great significance to guide the monitoring and treatment of patients with a lung cancer after radiotherapy.

The invention discloses a multimodal molecular imaging strategy for radiation-induced brain injury biomarkers after nasopharyngeal carcinoma radiotherapy, which specifically comprises the sequential steps of sample image acquisition, image analysis, brain segmentation, white matter fiber tract tracking, network construction and classification. It is discovered herein that a brain functional network connection mode may be used for monitoring dotting and for deciding thinking of functions according to the structure, and that the most reliable way to assess brain functions is to understand the anatomy of the brain and its underlying cerebral circuitry. Therefore, the study of the anatomical network between the white matter regions of the brain can supplement the understanding of the pathophysiological mechanism of radiation-induced brain injury, which is of great significance to exploring the neurological basis of cognitive dysfunction after radical radiotherapy.

The invention provides a preparation method of anti-tumor microparticles. The preparation method includes the following steps: 1) taking in-vitro tumor cells, performing primary tumor cell culture soas to obtain primary tumor cells; 2) irradiating the primary cancer cells and culture solution obtained in the step 1) with X rays, and collecting the supernatant after radiotherapy so as to obtain amixture of the desired microparticles and apoptotic tumor cell fragments; and 3) performing gradient centrifugation on the mixture obtained in the step 2) so as to obtain the anti-tumor microparticles. The invention also provides an anti-tumor microparticle drug, and the drug is obtained through purification and concentration of the anti-tumor microparticles. The anti-tumor microparticles which are prepared by using the preparation method of the anti-tumor microparticles can be applied to preparation of anti-tumor drugs, and the technical problem of no applicability of conventional radiotherapy can be solved.

Disclosed are applications of a mussel adhesive protein or preparations thereof in suppression of skin inflammations. Specifically disclosed are applications of a mussel adhesive protein, preparations thereof and applications thereof in dermatitis, eczema, skin ulcer, technologies related to burns (comprising skin grafting), perniones, surgical incisions, herpes, abrasions, scars, psoriasis, erythema multiforme, skin damage after radiotherapy, skin cancers, folliculitis, urticaria and drug eruption, and applications in sunburn, polymorphous light eruption, pathological alopecia (comprising hair transplant), acne vulgaris, rosacea (that is, acne rosacea), and the like, and applications in the treatment of otitis externa.

The invention provides a medicament for promoting a hematopoietic function after radiotherapy. The medicament is prepared from the following medicaments: 20g of astragalus, 15g of pilose asiabell root, 15g of Chinese wolfberry, 10g of American ginseng, 15g of dwarf lilyturf tuber, 12g of Indian buead, 8g of Chinese magnoliavine fruit, 12g of largehead atractylodes rhizome, 12g of officinal magnolia bark, 7g of Chinese angelica, 8g of tangerine peel, 8g of tuber fleeceflower root, 8g of giant knotweed rhizome, 7g of eucommia bark, 8g of yerbadetajo herb, 8g of baked ginger and 4g of liquoric root. The medicament provided by the invention has a significant promotion effect on the hematopoietic function of cancer patients after radiotherapy.

The invention provides a preparation method of microparticles for preventing novel coronavirus and an application, and relates to the field of vaccines. Specifically, the preparation method comprisesthe following steps: 1) constructing recombinant plasmids for overexpression of a spike (S) protein; 2) packaging the recombinant plasmids into lentiviral particles; 3) infecting fibroblasts with thelentiviral particles to obtain tool cells for expressing of S protein; 4) performing X-ray irradiation on the obtained tool cells and a culture solution, and collecting supernatant after radiotherapyto obtain a mixture of required microparticles and apoptotic tool cell debris; and 5) performing centrifuging, concentrating and purifying on the obtained mixture to obtain a vaccine. According to theinvention, the microparticles released by radiotherapy induction tool cells are used as a carrier, so that the antiviral immunity of an organism can be directly activated under the condition of overexpression of the novel coronavirus S protein, and a neutralizing antibody for resisting the novel coronavirus is generated. According to the invention, an organism can be induced to generate a high-level neutralizing antibody immune response, and besides, good biological safety is achieved.

Use of tellurium-containing compounds in a method of conception and / or for maintaining and / or augmenting fertility in female following chemotherapy and / or radiotherapy is disclosed. The tellurium-containing compound is utilized in combination with a chemotherapeutic agent and / or radiation, such that the female treated by the chemotherapeutic agent and / or radiation and by the tellurium-containing compound is instructed to refrain from conceptive sex for a pre-determined time period, following the chemotherapy and / or radiotherapy, during which conception is undesired. The tellurium-containing compound is utilized in combination with a chemotherapeutic agent and / or radiation, such that the female treated by the chemotherapeutic agent and / or radiation and by the tellurium-containing compound is instructed to refrain from sex and / or from reproduction for a pre-determined time period, and is then allowed to practice reproduction.

The invention discloses an arm support for preventing armpit fester after radiotherapy. The support is placed between the upper arm of the arm below the armpit and the trunk, an arm supporting plate is fixedly attached to the upper arm, a trunk fixing plate and the trunk are fixed, and the arm supporting plate and the trunk fixing plate are connected through a plurality of supporting rods; and trunk bandages are arranged on two sides of the trunk fixing plate. The invention provides the arm support for preventing armpit fester after radiotherapy. The support is placed between the arm below thearmpit and the trunk, one end of the support is fixed to the trunk, the other end of the support supports the upper arm of the arm, a proper angle is kept between the upper arm of the arm and the trunk, inflammation or infection caused by unsmooth ventilation and sweating of the skin at the armpit is prevented, and fatigue of a patient due to long-time arm lifting is avoided.

The invention provides a preparation method of anti-tumor microparticles modified by genetic engineering. The preparation method comprises the following steps: S1, constructing recombinant plasmids for overexpression of GM-CSF and transmembrane expression of GM-CSF; S2, obtaining isolated tumor cells for primary tumor cell culture, and obtaining primary tumor cells; S3, packaging slow virus particles with overexpression of GM-CSF and transmembrane expression of GM-CSF; S4, infecting the primary tumor cells obtained in the step S2 to obtain primary tumor cells with overexpression of GM-CSF andtransmembrane expression of GM-CSF; S5, carrying out X-ray irradiation on the primary tumor cells obtained in the step S4 and a culture solution, and collecting the supernatant after radiotherapy to obtain a mixture of required microparticles and apoptotic tumor cell fragments; and S6, centrifuging the mixture obtained in the step S5. The invention can solve the technical problems of poor effect,large side effect, easy generation of drug resistance and inhibition of organism immunity of conventional local chemotherapy.

The invention provides a post-radiotherapy upper limb nursing and exercising device. The problem that an existing breast cancer postoperative stretching device is inconvenient to carry and carry is effectively solved. The device comprises a bottom plate, wherein a transmission shaft is arranged at the right end of the bottom plate; triangular plates are rotationally connected to the front end andthe rear end of the transmission shaft respectively; connecting cylinders are arranged on the front side and the rear side of the transmission shaft respectively; short supporting rods are arranged atthe upper ends of the connecting cylinders; long supporting rods are arranged at the upper ends of the connecting cylinders; a backrest is arranged between the two long supporting rods; sliding grooves are formed in the long supporting rods; U-shaped sleeves are rotationally connected to the upper ends of the sliding grooves; connecting shafts are arranged in the U-shaped sleeves; swing rods arearranged at the opposite ends of the two connecting shafts; kidney-shaped grooves are formed in the swing rods; guide columns are slidably connected in the kidney-shaped grooves; transmission rods arearranged at the opposite ends of the two guide columns; the two transmission rods are hinged to the short supporting rods through pin shafts respectively; moving grooves are formed in the left sidesof the swing rods; connecting columns are arranged in the moving grooves; and grab handles are arranged at the opposite ends of the two connecting columns. The device is simple in structure, convenient to operate, novel in conception and high in usability.

The invention discloses a pharmaceutical composition for treating xerostomia after nasopharyngeal carcinoma radiotherapy, and relates to the technical field of traditional Chinese medicines. The pharmaceutical composition is prepared from the following raw materials: cassia twig, baked ginger, radix rehmanniae recen, radix ophiopogonis, radix adenophorae, radix trichosanthis, radix polygonati officinalis, lily, herba dendrobii, fructus lycii, fructus mume, radix paeoniae alba and liquorice root; and furthermore, the pharmaceutical composition is prepared from the following components in parts by weight: 3-9 parts of the cassia twig, 3-15 parts of the baked ginger, 10-30 parts of the radix rehmanniae recen, 6-20 parts of the radix ophiopogonis, 9-30 parts of radix adenophorae, 15-30 parts of the radix trichosanthis, 6-15 parts of the radix polygonati officinalis, 15-30 parts of the lily, 15-30 parts of the herba dendrobii, 6-20 parts of the fructus lycii, 10-20 parts of the fructus mume, 15-30 parts of the radix paeoniae alba and 3-10 parts of the liquorice root. The pharmaceutical composition has the effects of seeking yin from yang and helping produce saliva and slake thirst, and has a remarkable effect on treating xerostomia after nasopharyngeal carcinoma radiotherapy.

The invention discloses a post-radiotherapy mouth opening exercising device for a head and neck tumor patient. The device comprises a connecting mechanism, a mounting strip, a button battery, a driving mechanism, a connecting strip, a control mechanism, an anti-rotating pin and a pressing block. According to the post-radiotherapy mouth opening exercising device for a head and neck tumor patient, apatient does not need to actively open the mouth, and the mouth of the patient can subjected to reciprocating mouth opening training treatment in a passive state for, so that the phenomena that reactive exudation, hardening, maxillofacial soft tissue fibrosis, adhesion, contracture and limited joint movement are generated on the treatment part of the patient. Therefore, by means of the device, the exercise effect of the mouth of the patient is improved, and the exercise efficiency of the mouth of the patient is also improved.

The invention provides a traditional Chinese medicine formula for preventing and treating immunosenescence. The traditional Chinese medicine is prepared from the following medicaments in parts by weight: 6-600 parts of prepared rhizome of adhesive rehmannia, 5-500 parts of stems of noble dendrobium, 5-500 parts of Chinese yam, 5-500 parts of wolfberry fruits, 4-400 parts of common macrocarpium fruits, 6-600 parts of Chinese dodder seeds, 4-400 parts of eucommia barks, 3-300 parts of cassia barks, 3-300 parts of Chinese angelica, 6-600 parts of milkvetch roots, 5-500 parts of white paeony roots, 5-500 parts of fragrant solomonseal rhizome and 5-500 parts of szechuan lovage rhizome. Meanwhile, the invention also provides a preparation method of the traditional Chinese medicine formula. The traditional Chinese medicine provided by the invention can promote the activity of Tn and Th1 type subgroups in T cell subgroups in a targeting manner while improving the indexes of lymphoid organs including the spleen, the thymus and the like and the NK and NKT cell activity, and can prevent and treat the immunosenescence of T cells and promote the immunologic reconstitution of the T cells after radiotherapy.

The invention discloses a radiotherapy protective agent as well as a preparation method and application thereof, belongs to the technical field of radiotherapy protection, and solves the problem of poor protection effect of gastrointestinal tract radiotherapy protective agents by oral administration in the prior art. The preparation method of the radiotherapy protective agent comprises the following steps: mixing gelatin-based hydrogel and a hydrogen sulfide donor GYY4137 at room temperature, and stirring the components to obtain a gelatin@hydrogen sulfide donor compound in a manner of regulating the pH value of gelatin nanoparticles synthesized by a crosslinking method to obtain the gelatin-based hydrogel, wherein the gelatin-based hydrogel wraps the hydrogen sulfide donor GYY4137 through electrostatic acting force and physical adsorption. The acid-sensitive sustained-release oral radiotherapy protective agent prepared by the invention can reduce physical damage to gastrointestinal tracts during radiotherapy. The invention provides a new thought and a new method for protection of patients after radiotherapy clinically.

The invention discloses a preparation method of anti-tumor macrophages. The method comprises the following steps of obtaining primary bone marrow stem cells or separating mononuclear cells in peripheral blood for primary cell culture, adding a colony stimulating factor, and after 7 days, obtaining macrophages; obtaining in-vitro tumor cells for primary tumor cell culture, and obtaining primary tumor cells; performing radiotherapy irradiation on the obtained primary tumor cells and a culture solution, collecting supernate after radiotherapy, and obtaining a mixture of required microparticles and apoptotic tumor cell debris; centrifuging the obtained mixture to obtain tumor antigen-carrying microparticles; and treating the primary macrophages obtained in the step 1 with the obtained microparticles to obtain the anti-tumor macrophages. According to the preparation method of the anti-tumor macrophages, personalized treatment is realized, and the macrophages capable of aiming at different tumor antigens of patients is prepared; and the preparation process is simple and relatively easy in production.

The invention relates to the technical field of medical instruments, in particular to a mouth gag for rehabilitation exercise after oral cancer radiotherapy. A threaded rod is movably connected to theouter surface of the middle of a supporting block, gears are engaged with the outer surfaces of the two sides of the threaded rod and located on the outer side of the supporting block, and a first connecting rod is movably connected to the outer surface of each gear; a push plate is movably connected to one end of each first connecting rod, a fixing shaft is fixedly connected to the outer surfaceof the supporting block and located on one side of each push plate, adjusting rods are movably connected to the two sides of the outer wall of each fixing shaft, a limiting spring is fixedly connected between the outer surfaces of the two adjusting rods on one side of the each push plate, a top plate is fixedly connected to the outer surface of each adjusting rod, and a jaw plate is fixedly connected to one ends of the two adjusting rods on one side of each push plate. Due to the fact that meshing between the threaded rod and the gears is easy to control, the threaded rod is rotated to enablethe opening and closing degrees of the oral cavity to be equal each time, over excitation action cannot be generated on the oral cavity, and the mouth gag can better adapt to the comfort degree of different people.

The invention relates to the field of biological medicines, relates to a DNA (Deoxyribose Nucleic Acid) damage repairing medicine, and in particular relates to application of RORa protein and an agonist thereof in preparation of an acute DNA damage repairing agent. According to the scheme, a large number of in-vivo experiments prove that under the condition that RORa protein is activated, cell acute DNA damage repair can be accelerated, especially DNA damage caused by gamma-ray irradiation can be effectively relieved, DNA self-repair of damaged cells can be accelerated, and the RORa protein can be applied to DNA repair protection after radiotherapy and has a protective effect on radioactive ray damage. The RORa protein agonist can solve the technical problem that a large number of adverse reactions occur in the tumor radiotherapy process, and then the radiotherapy effect is improved. The DNA repair scheme depending on the RORa protein is clear in action target, the RORa protein agonist is small in toxic effect, and the drug is safe and efficient and has good application prospects.

Disclosed are applications of a mussel adhesive protein or preparations thereof in suppression of skin inflammations. Specifically disclosed are applications of a mussel adhesive protein, preparations thereof and applications thereof in dermatitis, eczema, skin ulcer, technologies related to burns (comprising skin grafting), perniones, surgical incisions, herpes, abrasions, scars, psoriasis, erythema multiforme, skin damage after radiotherapy, skin cancers, folliculitis, urticaria and drug eruption, and applications in sunburn, polymorphous light eruption, pathological alopecia (comprising hair transplant), acne vulgaris, rosacea (that is, acne rosacea), and the like, and applications in the treatment of otitis externa.

The invention belongs to the technical field of traditional Chinese medicines and particularly relates to traditional Chinese medicine composition for preventing and controlling post-radiotherapy side effects. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 3-5 parts of caulis spatholobi, 3-8 parts of acanthopanax root, 3-5 parts of ophiopogon root, 3-5 parts of carex kobomugi ohwi, 3-5 parts of ginkgo root, 3-5 parts of manyflower supplejack root, 3-5 parts of cyananthus incanus hook, 3-5 parts of astragalus membranaceus, 2-3 parts of astragalus membranaceus, 3-5 parts of chinaroot greenbrier, 3-5 parts of lophatherum gracile, 3-8 parts of sweet potato leaves, 3-5 parts of sculellaria barbata, 3-8 parts of angelica sinensis and 5-8 parts of poria cocos. The traditional Chinese medicine composition is prepared into decoction. The traditional Chinese medicine composition has effects of tonifying deficiency and vital energy, invigorating spleen, promoting appetite, removing toxic materials and facilitating urination due to addition of the traditional Chinese medicine raw materials, and is suitable for post-radiotherapy whole-body response and favorable for recovering physical strength of patients, accelerating removal of toxins in a human body, relieving a lump heat symptom and increasing the number of leukocytes.

The invention provides a preparation method and an application of an anti-tumor vaccine antigen raw material. The method comprises the following steps: (1) obtaining in-vitro tumor tissues and separating and extracting primary tumor cells; (2) collecting the primary tumor cells obtained in the step (1) and then carrying out radiotherapy treatment, and (3) carrying out crushing and gradient centrifugation on the cells subjected to radiotherapy obtained in the step (2), and collecting tumor cell membranes carrying new antigens generated by radiotherapy induction so as to obtain the anti-tumor vaccine antigen raw material. The anti-tumor vaccine antigen raw material provided by the invention can be used for preparing an anti-tumor vaccine, and an antigen generated after radiotherapy is used as a vaccine antigen, so that the treatment effect of the tumor vaccine can be improved, and the limitation of a conventional tumor vaccine is broken through.

The invention relates to the technical field of medical instruments, in particular to a mouth gag for rehabilitation exercise after oral cancer radiotherapy. The mouth gag for rehabilitation exercise after oral cancer radiotherapy comprises a rectangular fixing plate, reciprocating mechanisms are installed on the upper portion and the lower portion of the rectangular fixing plate, the reciprocating mechanisms are used for exercising muscles of the mouth of a patient, and each reciprocating mechanism comprises a first telescopic mechanism and a plurality of second telescopic mechanisms. By means of the structural design of the reciprocating mechanisms, the rehabilitation exercise can be effectively conducted on the patient, the exercise time is shortened, the influence on rehabilitation of the patient is avoided, and then recovery of the oral cavity of the patient is guaranteed; and through the structural design of a medicine spraying mechanism, medicine can be effectively sprayed into the oral cavity of the patient, local blood circulation of the oral cavity of the patient can be promoted, and then the rehabilitation exercise effect is improved.

The health-care traditional Chinese medicine cigarette has the effects of reinforcing qi and nourishing blood, nourishing yin and supporting yang, clearing and activating the channels and collaterals, promoting blood circulation to remove blood stasis, resolving dampness and harmonizing the stomach, strengthening the spleen and invigorating the stomach, clearing away heat and toxic materials and the like, can effectively achieve qi and blood tonifying, strengthen the body resistance and tonify deficiency and effectively improve the immunity of the human body, and can treat various symptoms caused by qi and blood deficiency. The traditional Chinese medicine composition can be used for effectively conditioning low blood pressure, obesity and the like, and can also be used for rehabilitation treatment after chemotherapy or radiotherapy of cancer patients.

The invention relates to a brain tumor radiotherapy mode intelligent selection method, system and device and a medium, and the method comprises the steps: constructing a multi-mode MRI brain tumor segmentation model, carrying out the brain tumor ROI segmentation of a multi-mode MRI image before and after radiotherapy of a patient, and obtaining a brain tumor pre-radiotherapy region and a brain tumor post-radiotherapy residual region which are paired; constructing a brain tumor diagnosis prognosis model, and taking the effective feature vectors as input to obtain prediction results of pathological grading and radiotherapy prognosis; constructing a brain tumor radiotherapy mode intelligent selection model, and taking image gene features and radiotherapy sensitive features before radiotherapy as input to obtain an optimal radiotherapy mode; and constructing a brain tumor radiotherapy curative effect visual model, and obtaining a predicted post-radiotherapy MRI image by taking the brain tumor MRI image of the patient before radiotherapy, the prediction results of pathological grading and radiotherapy prognosis and the optimal radiotherapy mode as input. The method can be widely applied to the medical image analysis technology and the application field.

The invention discloses a recurrent nasopharynx cancer radiomics data processing method, system and device and a storage medium. The radiomics data processing method comprises the following steps: acquiring MRI image data of a patient with recurrent nasopharyngeal carcinoma; extracting image data for analysis, segmenting a focus, extracting image features, and screening image omics key features; and inputting the radiomics key features into a random forest model obtained through training to predict the risk of nasopharyngeal necrosis. According to the invention, accurate guidance is provided for prediction of nasopharyngeal necrosis risk and formulation of a treatment scheme for patients with recurrent nasopharyngeal carcinoma, so that a part of high-risk patients with nasopharyngeal necrosis are prevented from bad outcomes after receiving reradiotherapy, and individualized accurate diagnosis and treatment of recurrent nasopharyngeal carcinoma are promoted.

The present invention relates to the field of lung cancer treatment. Specifically, it provides a kit for predicting or assisting in predicting the risk of radiation pneumonitis after lung radiation. A system for detecting the genotypes of genetic biomarkers for grade 2 or above radiation pneumonitis, in which a total of 31 genetic biomarkers can be used as detection and evaluation targets. The kit can accurately and effectively predict whether a patient’s chest tumor will cause radiation pneumonitis of grade 2 or above after receiving radiation therapy. It is easy to use, easy to operate, and the result is reliable. important guiding significance.