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Application of bone marrow mesenchymal stem cell to prevention of radiation-induced lung injury

A technology for radiation-induced lung injury and bone marrow mesenchyme, which can be used in the field of biomedicine to solve problems such as ineffectiveness

Inactive Publication Date: 2019-03-12
中科广聚(北京)生物医学技术中心有限公司 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the main reports in the literature focus on the therapeutic effect of mesenchymal stem cells after the generation of radiation pneumonitis, which is even ineffective after the generation of radiation pulmonary fibrosis in the later stage

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  • Application of bone marrow mesenchymal stem cell to prevention of radiation-induced lung injury
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  • Application of bone marrow mesenchymal stem cell to prevention of radiation-induced lung injury

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Embodiment Construction

[0034] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings. Apparently, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0035] In order to solve the problems in the prior art, the present invention provides a new medical application of bone marrow mesenchymal stem cells, that is, the application of bone marrow mesenchymal stem cells in preventing radiation lung injury, including radiation pneumonitis and advanced pulmonary fibrosis.

[0036] 1. Experimental method:

[0037] (1) Isolation method of bone mesenchymal stem cells

[0038] 1. Preparation:

[0039] (1) Purchase 4-6 weeks of healthy C57BL / 6N mice, and the cell viabi...

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Abstract

An embodiment of the invention provides application of a bone marrow mesenchymal stem cell to prevention of radiation-induced lung injury. The application of the bone marrow mesenchymal stem cell to prevention of the radiation-induced lung injury is the use of the bone marrow mesenchymal stem cell for prevention of radiation pneumonitis and advanced fibrosis and the improvement of the survival rate of the radiation-induced lung injury. Through experiments, the effectiveness of the bone marrow mesenchymal stem cell in preventing radiation-induced lung injury, including radiation pneumonitis andadvanced fibrosis, is verified. The new medical use of the bone marrow mesenchymal stem cell is developed, the bone marrow mesenchymal stem cell is applied to preventing radiation-induced lung injury, including radiation pneumonitis and advanced pulmonary fibrosis, in a groundbreaking way, and a new choice is provided for clinical treatment.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of bone marrow mesenchymal stem cells in preventing radiation-induced lung injury. Background technique [0002] Radiation-induced lung injury is a relatively common side effect during radiation therapy. Although radiation exposure can be localized with the maturity of radiation technology, it is still difficult to alleviate radiation-induced lung injury. Patients often reduce the dose of radiation therapy or even terminate radiation therapy due to this complication. [0003] Radiation lung injury is generally divided into two stages. The early stage mainly manifests as radiation pneumonitis, and the long-term pneumonia eventually forms irreversible radiation fibrosis. At present, the molecular mechanism of radiation-induced lung injury is still unclear, and it is generally believed that the radiation dose exceeds the self-repair ability. [0004] Stem cells ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/28A61P11/00C12N5/0775
CPCA61P11/00A61K35/28C12N5/0663C12N2509/00
Inventor 姬广聚杨智广包勇
Owner 中科广聚(北京)生物医学技术中心有限公司
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