Method of building radiation pneumonitis model

A radiation pneumonia and model technology, applied in the field of medical research, can solve the problems of high mortality, poor survival status of experimental animals, inability to provide experimental models for medical research, etc., and achieve the effect of improving the quality of life, stabilizing long-term survival, and good survival status.

Inactive Publication Date: 2013-07-24
尹中元 +2
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Problems solved by technology

[0002] Existing experimental animal models of radiation pneumonitis are all obtained by a single high-dose irradiation method. A single high-energy X-ray is used to give the whole chest 10-20Gy of radiation. The living conditions of experimental animals are poor, the...

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  • Method of building radiation pneumonitis model

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Embodiment 1

[0019] The method for establishing radiation pneumonitis model, comprises the following steps:

[0020] (1) Intravenously anesthetized experimental dogs, observe the respiratory rate and rhythm of the experimental dogs after successful anesthesia, confirm that the depth of anesthesia is appropriate, and carry out modeling experiments;

[0021] (2) Fix the experimental dog on the CT simulation body frame, select the right lung as the target organ for CT simulation scan, determine the isocenter level, calibrate the level through lead points, and then transmit the image to the CMS radiation treatment planning system ;

[0022] (3) Outline a certain volume of the right lung, while protecting the spinal cord, liver, and important organs and structures of the heart;

[0023] (4) Use the CMS radiotherapy planning system to formulate a radiation plan and set radiation parameters: a single irradiation dose of 4Gy, the number of irradiations is 6 times, and the interval between each ir...

Embodiment 2

[0026] The method for establishing radiation pneumonitis model, comprises the following steps:

[0027] (1) Intravenously anesthetized experimental dogs, observe the respiratory rate and rhythm of the experimental dogs after successful anesthesia, confirm that the depth of anesthesia is appropriate, and carry out modeling experiments;

[0028] (2) Fix the experimental dog on the CT simulation body frame, select the right lung as the target organ for CT simulation scan, determine the isocenter level, calibrate the level through lead points, and then transmit the image to the CMS radiation treatment planning system ;

[0029] (3) Outline a certain volume of the right lung, while protecting the spinal cord, liver, and important organs and structures of the heart;

[0030] (4) Use the CMS radiotherapy planning system to formulate a radiation plan and set radiation parameters: a single irradiation dose of 8Gy, the number of irradiations is 4 times, and the interval between each ir...

Embodiment 3

[0033] (1) Intravenously anesthetized experimental dogs, observe the respiratory rate and rhythm of the experimental dogs after successful anesthesia, confirm that the depth of anesthesia is appropriate, and carry out modeling experiments;

[0034] (2) Fix the experimental dog on the CT simulation body frame, select the right lung as the target organ for CT simulation scan, determine the isocenter level, calibrate the level through lead points, and then transmit the image to the CMS radiation treatment planning system ;

[0035] (3) Outline a certain volume of the right lung, while protecting the spinal cord, liver, and important organs and structures of the heart;

[0036] (4) Use the CMS radiotherapy planning system to formulate radiation plans and set radiation parameters: a single irradiation dose of 8Gy, irradiation times of 3 times, and irradiation intervals of 72 hours, and transmit the radiation plan and parameters to the Siemens Medical Linear Accelerator through the ...

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Abstract

The invention relates to the field of medical research, in particular to a method of building a radiation pneumonitis model. The method of building the radiation pneumonitis model comprises the following steps: (1) carrying out intravenous anesthesia on an experimental dog, and carrying out a modeling experiment when depth of anesthesia is suitable; (2) fixing the experimental dog on a CT analog body frame, choosing the right lung to carry out CT analog scanning, and transmitting an image to a radiotherapy plan system; (3) sketching the right lung, and meanwhile protecting vitals and structures of a spinal cord, a liver and a heart; (4) making an irradiation plan, setting an irradiation parameter, and transmitting the irradiation plan and the irradiation parameter to a medical linear accelerator; and (5) radiating according to the irradiation plan and the irradiation parameter, observing the breathing condition and narcotism of the experimental dog in the process of radiating, and observing the change of iconography of the radiated lung of the experimental dog. The method of building the radiation pneumonitis model can obtain experimental animals which are stable in a long-term surviving state, and each long-term surviving index of the radiation pneumonitis in an evolutionary process is convenient to observe.

Description

technical field [0001] The invention belongs to the field of medical research, in particular to a method for establishing a radiation pneumonitis model. Background technique [0002] Existing experimental animal models of radiation pneumonitis are all obtained by a single high-dose irradiation method. A single high-energy X-ray is used to give the whole chest 10-20Gy of radiation. The living conditions of experimental animals are poor, the mortality rate is high, and the evolution of radiation pneumonitis cannot be completely observed. process, let alone dynamically monitor the various biochemical indicators of the experimental animal, and cannot provide an experimental model for subsequent medical research. Contents of the invention [0003] The purpose of the present invention is to provide a method for establishing a radiation pneumonitis model, which can enable experimental animals to obtain a stable long-term survival state, facilitate observation of the evolution pro...

Claims

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Application Information

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IPC IPC(8): A61B19/00A61D7/00A61N5/00
Inventor 王琼
Owner 尹中元
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