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Method for early monitoring radioactive pneumonia fibrosis caused by tumor radiotherapy

A technology for radiation pneumonitis and tumor radiotherapy, which is applied in the fields of molecular markers, early diagnosis and prognosis evaluation of radiation pneumonitis, and can solve problems such as undetermined diagnostic thresholds

Inactive Publication Date: 2017-01-11
QINGDAO CENT HOSPITAL
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  • Abstract
  • Description
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Problems solved by technology

[0003] At present, the pathogenesis of radiation pneumonitis is not fully understood. Although some indicators have been found to be correlated with radiation pneumonitis, the meaningful diagnostic threshold has not been determined.
There is no report on its application in the early diagnosis and prognosis of radiation pneumonitis

Method used

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  • Method for early monitoring radioactive pneumonia fibrosis caused by tumor radiotherapy
  • Method for early monitoring radioactive pneumonia fibrosis caused by tumor radiotherapy
  • Method for early monitoring radioactive pneumonia fibrosis caused by tumor radiotherapy

Examples

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Embodiment 1

[0075] A method for early monitoring of radiation pneumonitis fibrosis caused by tumor radiotherapy, through the design of human S100A8 and S100A9 primers and antibodies, early monitoring of radiation pneumonitis and pulmonary fibrosis, and assessment of disease prognosis.

[0076] Include the following steps:

[0077] (1) Determine the target detection objects, exclude those with stage IV extensive metastases, those who underwent lung surgery, those with asthma, severe chronic bronchitis, emphysema, pulmonary heart disease, severe lung infection or other serious diseases;

[0078] (2) Extract the genome of the patient's peripheral blood, and use the real-time quantitative PCR method to detect the variation range of S100A8 and S100A9 at the gene level. month, 2 months, 3 months;

[0079] (3) Analyze the expression difference of the target gene;

[0080] (4) Monitor for early radiation pneumonitis and pulmonary fibrosis based on the results and the evaluation of infectious pn...

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Abstract

The invention relates to a method for early monitoring radioactive pneumonia fibrosis caused by tumor radiotherapy, in particular to a method for early diagnosis and prognosis evaluation of radioactive pneumonia by using a molecular marker. By the design of primers S100A8 and S100A9 and antibodies of a human, generation of the radioactive pneumonia and the pulmonary fibrosis can be monitored in the early stage, and the prognosis of diseases can be estimated. The method has the advantages of simple operation, high sensitivity and high specificity.

Description

technical field [0001] The invention relates to a method for early monitoring radiation pneumonitis fibrosis caused by tumor radiotherapy, in particular to a method for molecular markers used for early diagnosis and prognosis evaluation of radiation pneumonitis. Background technique [0002] Radiation pneumonitis (RP) is an abnormal pathological manifestation of lung tissue after radiotherapy for a variety of malignant tumors (including lung cancer, breast cancer, and esophageal cancer). It is a common complication and can be divided into acute radiation inflammatory changes and Chronic fibrotic lesions. Mild cases have no obvious symptoms, and severe cases can cause extensive pulmonary fibrosis, respiratory dysfunction, and even respiratory failure, which is also the main cause of death from radiation-induced lung injury. At present, the countermeasures for radiation pneumonitis are mainly early prevention and early detection, but there are few monitoring indicators for de...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q1/6888C12Q2600/118
Inventor 李长优赵鹏
Owner QINGDAO CENT HOSPITAL
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