Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of s100a9 inhibitor in preparation of medicine for treating pancreatitis

A technology for S100A9 and pancreatitis, applied in the field of biomedicine, to improve cell viability and reduce cell damage

Active Publication Date: 2022-03-04
FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on the relationship between S100A9 and pancreatitis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of s100a9 inhibitor in preparation of medicine for treating pancreatitis
  • Application of s100a9 inhibitor in preparation of medicine for treating pancreatitis
  • Application of s100a9 inhibitor in preparation of medicine for treating pancreatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1. Experimental plan:

[0023] 1. Molecular docking: The 3D structures of S100A9 protein and VNN1 protein were downloaded from the RCSB protein database (PDB ID: 5I8N for S100A9, 4CYF for VNN1). Use the protein-protein docking function in ClusPro to simulate molecular docking and predict the binding affinity of the complex; use MOE v2018.01 to analyze the docking structure and interface residues, and finally generate molecular graphics by PyMOL, such as figure 1 shown.

[0024] 2. Virtual screening: The Dock module in MOE v2015.1001 is used for receptor-based virtual screening (SBVS). The S100A9 protein was defined as a receptor, and 100,000 compounds from Chemdiv were defined as a virtual screening library. The receptor binding site was selected near the residues interacting between S100A9 and VNN1, and the top 8 inhibitors were finally selected. The structural formulas of the 8 inhibitors are as follows figure 2 shown.

[0025] 3. Toxicity test: The toxicity of 8...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses the application of S100A9 inhibitors in the preparation of medicines for treating pancreatitis, and belongs to the technical field of biomedicine. An application of an S100A9 inhibitor in the preparation of a drug for treating pancreatitis, the S100A9 inhibitor is shown in Chemdiv ID: 0884‑0014 or 3948‑1191 or 3232‑0780. The present invention uses S100A9 inhibitors to pretreat pancreatitis in vitro models, and proves that S100A9 inhibitors (ID: 0884‑0014, 3948‑1191, 3232‑0780) can improve HPDE6‑C7 cell viability and reduce STC-induced cell damage. The invention provides a basis for using the S100A9 inhibitor as a novel medicine for treating pancreatitis.

Description

technical field [0001] The invention relates to the application of S100A9 inhibitors in the preparation of medicines for treating pancreatitis, and belongs to the technical field of biomedicine. Background technique [0002] Acute pancreatitis is a common clinical local inflammation of the pancreas. It is a digestive system disease mainly characterized by local necrosis of the pancreas and multiple organ dysfunction syndrome (MODS). At present, acute pancreatitis has formed a non-surgical treatment system based on early supportive treatment, but due to insufficient understanding of the pathogenesis of the disease, so far there is no specific preventive drug. Clinical observations in patients with pancreatitis found that the pancreatic duct is most susceptible to noxious stimuli from cholelithiasis and endoscopic retrograde pancreatography, and the pancreatic duct is the tissue most likely to be exposed to noxious stimuli commonly seen in pancreatitis. Therefore, it is urgen...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K31/496A61K31/519A61K31/427A61P1/18
CPCA61K45/00A61K31/496A61K31/519A61K31/427A61P1/18
Inventor 尚东项红陶旭锋郭方悦周琪
Owner FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com