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A kind of traditional Chinese medicine preparation and its preparation and application

A traditional Chinese medicine preparation and signal transduction technology, which is applied in the direction of medical formulas, drug combinations, and medical preparations containing active ingredients, etc., can solve problems such as dependence, promote fibrinolysis, reduce lung inflammation, and improve microcirculation blood flow effect

Active Publication Date: 2021-08-03
HANGZHOU NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The current treatment for radiation pneumonitis is mainly the use of adrenal cortex hormones, which have a strong anti-inflammatory effect, but long-term use of hormones will lead to dependence on them and cause greater side effects

Method used

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  • A kind of traditional Chinese medicine preparation and its preparation and application
  • A kind of traditional Chinese medicine preparation and its preparation and application
  • A kind of traditional Chinese medicine preparation and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Astragalus 30g, Nansha ginseng 30g, Beisha ginseng 30g, Lily 10g, Dendrobium 10g, Aster 15g, Loquat leaf 20g, Bitter almond 12g, Baibu 15g, Angelica 18g.

[0038] Preparation method: Mix the components according to the formula, add 3 times the weight of water to soak for 20 minutes, cook at 120°C for 20 minutes, then adjust to 80°C and cook for 20 minutes, filter, repeat the filter cake, cook once, filter, and combine The filtrate was concentrated under reduced pressure (0.097Mpa, 50-60° C.) to 1.5 times the volume to obtain a decoction with a crude drug concentration of 2 g / ml.

Embodiment 2

[0040] Astragalus 30g, Nansha ginseng 25g, Beisha ginseng 25g, Lily 15g, Dendrobium 10g, Aster 15g, Loquat leaf 15g, Bitter almond 15g, Baibu 15g, Angelica 15g.

[0041] Preparation method: Mix the components according to the formula, add 4 times the weight of water to soak for 20 minutes, decoct at 120°C for 20 minutes, then adjust to 80°C for 20 minutes, filter, repeat the decoction of the filter cake once, filter, and combine the filtrate Concentrate under reduced pressure (0.097Mpa, 50-60° C.) to double the volume to obtain a decoction with a crude drug concentration of 2 g / ml.

Embodiment 3

[0043]Astragalus 30g, Nansha ginseng 30g, Beisha ginseng 30g, Lily 15g, Dendrobium 10g, Aster 15g, Loquat leaf 15g, Bitter almond 15g, Baibu 15g, Angelica 15g.

[0044] Preparation method: Mix the components according to the formula, add 3.5 times the weight of water to soak for 20 minutes, decoct at 120°C for 20 minutes, then adjust to 80°C for 20 minutes, filter, repeat the decoction of the filter cake once, filter, and combine the filtrate Concentrate under reduced pressure (0.097Mpa, 50-60° C.) to 1.8 times the volume to obtain a decoction with a crude drug concentration of 2 g / ml.

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Abstract

The invention discloses a traditional Chinese medicine preparation and its preparation and application. The preparation is made from the following raw materials by weight: 20-30 parts of Astragalus root, 20-30 parts of Nansha ginseng, 20-30 parts of Beisha ginseng, and 10-30 parts of Lily Radix. 20 servings, 5-15 servings of dendrobium, 10-20 servings of aster, 10-20 servings of loquat leaves, 10-20 servings of bitter almond, 10-20 servings of Bai Bu, and 10-20 servings of angelica. It has the functions of clearing the lungs, relieving cough and relieving asthma, nourishing qi, nourishing yin and promoting blood circulation. After taking, the drug can directly act on the lesions of radiation pneumonia, inhibit the exudation of inflammatory cells in the alveolar wall, pulmonary interstitial congestion, hemorrhage, edema and alveolar structure damage, reduce the TLR4 signaling pathway signaling molecule protein and local lung. The expression of cytokines in tissue-related cells can reduce the inflammatory response of the lungs and achieve the purpose of delaying or treating radiation pneumonitis.

Description

[0001] (1) Technical field [0002] The invention relates to a traditional Chinese medicine preparation, in particular to a traditional Chinese medicine preparation and its preparation and application in preventing and treating radiation pneumonitis. [0003] (2) Background technology [0004] The incidence of lung cancer and other thoracic malignant tumors is increasing year by year, becoming one of the important factors that endanger health. Radiation therapy is one of the important treatment methods. Radiation pneumonitis is a common complication after radiotherapy for thoracic malignant tumors, with an incidence rate of 5% to 15%, often causing serious clinical consequences. Mild cases have no obvious symptoms, and severe cases can cause extensive pulmonary fibrosis, respiratory dysfunction, and even respiratory failure. [0005] The current treatment for radiation pneumonitis is mainly the use of adrenal cortex hormones, which have powerful anti-inflammatory effects, but ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/904A61P11/00
CPCA61K9/0095A61K36/23A61K36/232A61K36/28A61K36/342A61K36/481A61K36/73A61K36/736A61K36/8967A61K36/8984A61K36/904A61K2236/331A61K2236/39A61K2300/00
Inventor 黄常新张东伟鲍艳红朱影雷艳敏
Owner HANGZHOU NORMAL UNIVERSITY
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